Journal
JOURNAL OF PSYCHIATRIC RESEARCH
Volume 44, Issue 6, Pages 409-412Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2009.10.009
Keywords
FXYD6; Association; Chinese Han population
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Funding
- National Natural Science Foundation of China [30700457]
- national S973 and 863 Programs [2007CB914703, 2006AA02A407]
- Shanghai Municipal Commission for Science and Technology
- Shanghai Leading Academic Discipline Project [B205]
- Shanghai Rising-Star Program [08QA14039]
- Chinese Academy of Sciences [KSCX2-YW-R-01]
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Choudhury et al. identified FXYD6 as a susceptible gene for schizophrenia in the London and Aberdeen populations. We genotyped D11S1998 and 8 SNPs (rs869789, rs11216567, rs10790212, rs876797, rs4938445, rs497768, rs11216598, rs11605223) in a Chinese sample consisting of 1514 schizophrenia patients and 1514 healthy controls. We also compared the expression levels of FXYD6 in lymphocytes in 86 schizophrenia patients and 94 controls. No association was detected either in D11S1998 or the 8 SNPs. No difference was found in expression level between patients and controls. Our study suggests that FXYD6 does not play a role in schizophrenia in the Chinese Han population. (C) 2009 Published by Elsevier Ltd.
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