Journal
JOURNAL OF PSYCHIATRIC RESEARCH
Volume 42, Issue 8, Pages 684-688Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2007.07.007
Keywords
vasopressin; DST; depression; suicide
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The purpose of the present study was to assess if AVP-neurophysin is associated with hypercortisolemia and suicidal behaviour in depressed patients. The study included 28 patients subgrouped into suicide attempters (n = 13) and nonattempters (it = 15). We assessed basal AVP-neurophysins concentrations and post-dexamethasone (DST) cortisol levels. Concentrations of AVP-neurophysins did not differ between DST suppressors and nonsuppressors: 0.29 +/- 0.13 ng/ml vs 0.36 +/- 0.21 ng/ml, (F = 1.1, df = 1, 27, p = 0.30). Suicide attempters did not differ from nonattempters for AVP-neurophysins levels. Our results fail to support a role of AVP in the early cortisol escape. (C) 2007 Elsevier Ltd. All rights reserved.
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