4.0 Article

CNS Drug Development: Part I: The Early Period of CNS Drugs

Journal

JOURNAL OF PSYCHIATRIC PRACTICE
Volume 16, Issue 5, Pages 334-339

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.pra.0000388628.44405.c0

Keywords

drug discovery; drug development; central nervous system drugs; antipsychotics; antidepressants; mood stabilizers

Categories

Funding

  1. Abbott
  2. Allergan
  3. Amylin
  4. AstraZeneca
  5. Biovail
  6. Boehringer-Ingelheim
  7. Covidien
  8. Cyberonics
  9. Dainippon Sumitomo
  10. Eli Lilly
  11. EnVivo
  12. Evotec
  13. GlaxoSmithKline
  14. Link Medicine
  15. Labopharm
  16. Lundbeck
  17. Pfizer
  18. PsychoGenics
  19. Psylin Neurosciences
  20. Rules-Based Medicine
  21. Takeda
  22. Targacept
  23. Transcept
  24. University of North Carolina at Chapel Hill
  25. Wyeth

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This column begins a new series on central nervous system (CNS) drug development. This series will review developments up to the present day and end with a forward-looking perspective on what to expect over the next 10-20 years. The goal of this series is to explain to practicing clinicians how drugs are developed and why CNS drug development is at an important juncture involving both significant challenges and opportunities. This column (Part 1) reviews the history of CNS drug development from the period before written history through the golden era (i.e., late 1940s-early 1960s) in which the first modern medications for anxiety, bipolar, depressive, and psychotic disorders were discovered by chance. It also describes the early era of rational drug development in which other agents (e. g., thioridazine, fluphenazine, haloperidol, imipramine) were developed based on those first agents. The blueprint laid down for development of antibiotics is reviewed in relation to its impact on CNS drug development. The impact of the blockbuster business model and modern marketing/sales approaches on CNS drug development is also discussed. (Journal of Psychiatric Practice 2010;16:334-339)

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