Article
Dentistry, Oral Surgery & Medicine
Abeer Essam Hakam, Gabriela Vila, Poliana Mendes Duarte, Marcia Phemba Mbadu, Dannia Sulaiman Ai Angary, Ikramuddin Aukhil, Rodrigo Neiva, Helio Doyle Pereira da Silva, Jia Chang
Summary: This study found that patients taking antidepressants are at higher risk of dental implant failure, with users of SNRI and TCA having the highest risk of implant loss. However, conclusions about TCA are based on a limited number of cases.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Clinical Neurology
Ya-Mei Tzeng, I-Hsun Li, Hui-Han Kao, Jui-Hu Shih, Chin-Bin Yeh, Yi-Hsien Chen, Li-Ting Kao
Summary: This study found that antidepressants can reduce the subsequent risk of psoriasis in patients with major depressive disorder, particularly selective serotonin reuptake inhibitors and low-dose antidepressants have significant protective effects.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Public, Environmental & Occupational Health
Avital Fischer, Hedy S. Rennert, Gad Rennert
Summary: The study found that the use of SSRIs before and after breast cancer diagnosis is associated with increased mortality in breast cancer patients. Research is needed to further understand the mechanisms behind this association.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Abeer Essam Hakam, Poliana Mendes Duarte, Marcia Phemba Mbadu, Ikramuddin Aukhil, Helio Doyle Pereira da Silva, Jia Chang
Summary: This study found that the use of antidepressant medications was associated with higher alveolar bone levels and less clinical attachment loss in patients with periodontitis. Specifically, only SSRI class users and multiple-class users showed significantly less periodontal breakdown.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Psychiatry
Brian P. Brennan, Jiana Schnabel, Harrison G. Pope, James I. Hudson
Summary: The use of serotonergic antidepressants in hospitalized COVID-19 patients did not show a significant difference in outcomes compared to those not using antidepressants, based on the results of a study that aimed to replicate previous findings.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Chemistry, Multidisciplinary
Michal Wicinski, Bartlomiej J. Kaluzny, Slawomir Liberski, Daria Marczak, Jakub J. Kaluzny
Summary: Acute angle closure (AAC) is a rare but serious ophthalmological condition, often associated with the use of selective serotonin reuptake inhibitors (SSRIs). AAC in individuals receiving SSRIs is mainly caused by pupillary block mechanism, but may also result from other mechanisms such as uveal effusion.
APPLIED SCIENCES-BASEL
(2021)
Article
Clinical Neurology
Nam-Ju Ji, Seung-Yeon Jeon, Kyung-Joon Min, Myung Ki, Weon-Young Lee
Summary: This study investigated the relationship between the type of initial antidepressants and treatment adherence in outpatients with new onset depression. The results showed a significant association between initial antidepressant type and treatment adherence during the first three- and six-month treatment periods for employed and self-employed patients newly diagnosed with major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Pediatrics
Lourdes M. DelRosso, Oliviero Bruni, Maria P. Mogavero, Amy Fickensher, Carlos H. Schenck, Raffaele Ferri
Summary: This study aimed to investigate the frequency of antidepressant use in children undergoing polysomnography (PSG). It was found that among the 3,371 patients who underwent PSG, 367 children were taking antidepressants. Girls had a decreased sleep stage N3 compared to boys, and children with insomnia had longer sleep latency. Antidepressants were found to affect REM latency and percentage, and certain antidepressants were associated with periodic leg movements during sleep.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2023)
Article
Pharmacology & Pharmacy
Michael Frey, Lukasz Smigielski, Elvira Tini, Stefanie Fekete, Christian Fleischhaker, Christoph Wewetzer, Andreas Karwautz, Christoph U. Correll, Manfred Gerlach, Regina Taurines, Paul L. Plener, Uwe Malzahn, Selina Kornbichler, Laura Weninger, Matthias Brockhaus, Su-Yin Reuter-Dang, Karl Reitzle, Hans Rock, Hartmut Imgart, Peter Heuschmann, Stefan Unterecker, Wolfgang Briegel, Tobias Banaschewski, Joerg M. Fegert, Tobias Hellenschmidt, Michael Kaess, Michael Koelch, Tobias Renner, Christian Rexroth, Susanne Walitza, Gerd Schulte-Koerne, Marcel Romanos, Karin Maria Egberts, Paolo Magni
Summary: This study investigated the relationship between drug dose and serum concentration of fluoxetine in children and adolescents and established the therapeutic serum reference range. The study found a positive correlation between dose and serum concentration of fluoxetine and its metabolite, with higher body weight and female sex associated with lower serum concentrations and therapeutic response. Most patients showed marked or minimal improvements during treatment, with no reported adverse effects.
Review
Chemistry, Analytical
Ilona Oledzka, Alina Plenis, Piotr Kowalski, Tomasz Baczek, Anna Roszkowska
Summary: The pharmacotherapy of depression relies on different types of antidepressants, with SSRIs being the most commonly used first-line treatment. There is a growing demand for fast and accurate methods to monitor SSRI levels during depression therapy. Recent efforts have focused on developing instrumental methods that enable lower detection limits, better quantitation, and separation of multiple analytes, resulting in more reliable and selective determination of SSRIs. However, the preparation of biological samples for analysis remains a bottleneck in most analytical procedures. This review discusses recent advancements in methods for preparing various conventional and non-conventional complex biological matrices for precise determination of SSRI levels, as well as the advantages, challenges, and potential applications of these developed methodologies in clinical studies.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Clinical Neurology
Irene Visos-Varela, Maruxa Zapata-Cachafeiro, Maria Pineiro-Lamas, Eduardo Carracedo-Martinez, Marc Saez, Maria Teresa Herdeiro, Adolfo Figueiras, Angel Salgado-Barreira
Summary: The World Health Organization suggests finding alternatives to vaccines for COVID-19 prevention and treatment, such as selective serotonin reuptake inhibitors (SSRIs). This study assesses the effect of previous treatment with SSRIs on the severity of COVID-19 and susceptibility to SARS-CoV-2.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Shuzhe Zhou, Qinhong Ma, Yiwei Lou, Xiaozhen Lv, Hongjun Tian, Jing Wei, Kerang Zhang, Gang Zhu, Qiaoling Chen, Tianmei Si, Gang Wang, Xueyi Wang, Nan Zhang, Yu Huang, Qi Liu, Xin Yu
Summary: This study utilized machine learning models to explore baseline variables for predicting the 8-week treatment outcome of patients with MDD receiving SSRIs. Results showed that neurocognitive functions and anxiety symptoms were important predictors, with SVM achieving an accuracy of 74.49% and sensitivity and specificity of 0.899 and 0.422, respectively.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Elvira Tini, Lukasz Smigielski, Marcel Romanos, Christoph Wewetzer, Andreas Karwautz, Karl Reitzle, Christoph U. Correll, Paul L. Plener, Uwe Malzahn, Peter Heuschmann, Stefan Unterecker, Maike Scherf-Clavel, Hans Rock, Gisela Antony, Wolfgang Briegel, Christian Fleischhaker, Tobias Banaschewski, Tobias Hellenschmidt, Hartmut Imgart, Michael Kaess, Michael Koelch, Tobias Renner, Su-Yin Reuter-Dang, Christian Rexroth, Gerd Schulte-Koerne, Frank Theisen, Stefanie Fekete, Regina Taurines, Manfred Gerlach, Karin Maria Egberts, Susanne Walitza
Summary: This study examines the pharmacokinetics, pharmacodynamics, efficacy, and tolerability of sertraline in children and adolescents. The results show that dose and serum concentration have a significant impact on clinical efficacy, but not on side effects. Additionally, sertraline has good tolerability in children and adolescents. The study also reveals a diagnosis-specific effect between sertraline serum concentration and clinical efficacy for pediatric obsessive-compulsive disorder (OCD).
COMPREHENSIVE PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Hugo R. Arias, Katarzyna M. Targowska-Duda, Jesus Garcia-Colunga, Marcelo O. Ortells
Summary: SSRIs are believed to alleviate depression symptoms by elevating synaptic 5-HT levels through inhibiting serotonin reuptake transporters and may also modulate other neurotransmitter systems by inhibiting nAChRs. There is a strong association between major depression and smoking, but SSRIs are not effective for smoking cessation therapy. In patients with major depressive disorder, there is lower availability of functional nAChRs, possibly due to higher endogenous ACh levels.
Article
Clinical Neurology
Gernot Fugger, Lucie Bartova, Chiara Fabbri, Giuseppe Fanelli, Markus Dold, Marleen Margret Mignon Swoboda, Alexander Kautzky, Joseph Zohar, Daniel Souery, Julien Mendlewicz, Stuart Montgomery, Dan Rujescu, Alessandro Serretti, Siegfried Kasper
Summary: This study compared the sociodemographic and clinical characteristics of MDD patients primarily prescribed SSRIs with those receiving alternative first-line ADs. The results showed that patients prescribed SSRIs had a more favorable profile, with lower odds of unemployment, current severity of depressive symptoms, melancholic features, suicidality, and current inpatient treatment. They were also less likely to receive add-on therapies and had a trend towards higher response rates.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)