Article
Geriatrics & Gerontology
Xuezhi Zhang, Wenwen Yu, Xuelei Cao, Yongbin Wang, Chao Zhu, Jialiang Guan
Summary: This study successfully identified several potential serum biomarkers of AD, and found that Cofilin 2 may play an important role in the pathology of AD.
Article
Oncology
Yao Lu, Deng Huang, Baolin Wang, Bowen Zheng, Jialong Liu, Juxian Song, Shuguo Zheng
Summary: This study found that FAM21C binds to CAPZA1 and inhibits its capping ability, thus promoting the invasion and migration of hepatocellular carcinoma cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Zhuang-Fei Chen, Ze-Hai Huang, Shi-Jun Chen, Yao-Dong Jiang, Zi-Ke Qin, Shao-Bin Zheng, Tong Chen
Summary: CapG is a newly identified oncogene in clear cell renal cell carcinoma (ccRCC) that is associated with advanced tumor stage, metastasis, and poor prognosis. Knockdown of CapG inhibits proliferation, migration, and invasion of 786-O cells, induces apoptosis, and disrupts RAC, CDC42, and ERK/MAPK signaling pathways. CapG may serve as a potential therapeutic target for ccRCC.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Nanoscience & Nanotechnology
Yong Wang, Rongfen Gao, Jinpeng Li, Shaotao Tang, Shuai Li, Qiangsong Tong, Shiwang Li
Summary: The study revealed upregulation of hsa_circ_0074854 in HCC, with its knockdown inhibiting tumor growth. Mechanistically, hsa_circ_0074854 knockdown reduced HCC cell migration and invasion by interacting with HuR. Moreover, hsa_circ_0074854 was transferred from HCC cells to macrophages via exosomes, suppressing macrophage M2 polarization and subsequently inhibiting HCC cell migration and invasion.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Genetics & Heredity
Huaping Chen, Junrong Wu, Liuyi Lu, Zuojian Hu, Xi Li, Li Huang, Xiaolian Zhang, Mingxing Chen, Xue Qin, Li Xie
Summary: This study identified the top ten hub genes related to immune cell infiltration and their prognostic value for hepatocellular carcinoma (HCC). These hub genes play a key role in predicting prognosis and could potentially serve as targets for immune-based intervention strategies in HCC.
FRONTIERS IN GENETICS
(2021)
Article
Gastroenterology & Hepatology
Chenhao Zhou, Jialei Weng, Chunxiao Liu, Shaoqing Liu, Zhiqiu Hu, Xiaoli Xie, Dongmei Gao, Qiang Zhou, Jialei Sun, Ruchen Xu, Hui Li, Yinghao Shen, Yong Yi, Yi Shi, Xia Sheng, Qiongzhu Dong, Mien-Chie Hung, Ning Ren
Summary: This study found that SLFN11, a member of the Schlafen (SLFN) family, plays a critical role in the response to immune checkpoint inhibitors (ICIs) in hepatocellular carcinoma (HCC) patients. SLFN11 deficiency promotes the infiltration of immunosuppressive macrophages and aggravates HCC progression. SLFN11 regulates the immune microenvironment by suppressing the Notch pathway and C-C motif chemokine ligand 2 transcription, and is associated with the response to ICIs. Inhibition of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 signaling pathway enhances the therapeutic efficacy of ICIs in HCC patients with low SLFN11 levels.
Article
Biotechnology & Applied Microbiology
Xiaoming Jiang, Zhe Chu, Yang Cao, Ying Tang, Ying Shi, Xu Shi
Summary: Hepatocellular carcinoma (HCC) is a common and deadly malignancy worldwide. This study found that the downregulation of PDLIM2 in HCC is associated with poor prognosis, and overexpressed PDLIM2 can inhibit HCC cell proliferation, migration, invasion, and EMT by regulating beta-catenin, suggesting PDLIM2 as a promising therapeutic target for HCC.
CANCER GENE THERAPY
(2021)
Article
Pharmacology & Pharmacy
Z-Y Guo, Z-T Zhu
Summary: NCAPG upregulation is associated with poor prognosis in hepatocellular carcinoma patients with vascular invasion, and serves as an independent predictor of patient survival outcomes. NCAPG expression levels are related to DNA hypomethylation status, tumor immune cell infiltration, and immune cell-related biomarker expression.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Oncology
Hui Sheng, Minjie Mao, Kewei Huang, Hailin Zheng, Wen Liu, Yongneng Liang
Summary: This study established and validated an effective hematological nomogram for predicting microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients. The nomogram included variables such as age, sex, TNM stage, aspartate aminotransferase, alpha fetoprotein, C-reactive protein, and thrombin time. The nomogram showed good discrimination and calibration, and may be used as a noninvasive tool for preoperative MVI prediction in HCC.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Article
Microbiology
Deying Zou, Jiang Chang, Shiying Lu, Jianfeng Xu, Pan Hu, Kai Zhang, Xiaoli Sun, Wei Guo, Yansong Li, Zengshan Liu, Honglin Ren
Summary: This study compared the proteomes of A. baumannii strains and identified potential virulence factors associated with enhanced pathogenicity through protein-protein interaction network analysis, phylogenetic analysis, and animal infection models. The results showed that the pathogenicity of strain CCGGD201101 was increased by 180.5-fold compared to the standard strain. The study helps to better understand the mechanisms of virulence enhancement.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Oncology
Osman Oecal, Michael Ingrisch, Muzaffer Reha Uemuetlue, Bora Peynircioglu, Christian Loewe, Otto van Delden, Vincent Vandecaveye, Bernhard Gebauer, Christoph J. Zech, Christian Sengel, Irene Bargellini, Roberto Iezzi, Alberto Benito, Maciej Pech, Peter Malfertheiner, Jens Ricke, Max Seidensticker
Summary: The study included 376 patients with advanced HCC, and found that certain imaging features were predictive of worse overall survival (OS) and liver decompensation (LD), while other features were associated with better OS. The use of sorafenib and selective internal radiation therapy for HCC treatment may benefit from considering these imaging biomarkers along with clinical parameters.
BRITISH JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Shengqian Hong, Jialing Zhang, Shiqi Liu, Quan Jin, Jingqi Li, Anliang Xia, Jianbo Xu
Summary: In this study, the differential protein expression profiles associated with MVI in HCC were identified using quantitative proteomics techniques. The upregulation of MSH6 and MSH2 were found to be notably associated with MVI in HCC, and further validation confirmed their correlation with aggressive disease characteristics and poor prognosis. Combined use of MSH6 and MSH2 showed a high sensitivity and specificity for HCC diagnosis. Knockdown of MSH6 and MSH2 significantly inhibited HCC cell proliferation and invasion.
HEPATOLOGY RESEARCH
(2023)
Article
Oncology
Yanhui Yu, Lijuan Bian, Renfei Liu, Yitong Wang, Xia Xiao
Summary: Circ_0061395 promotes HCC progression by regulating the miR-877-5p/PIK3R3 axis, demonstrating a novel mechanism for HCC advancement. Circ_0061395 silencing inhibited tumor growth and malignant behaviors of HCC cells, while miR-877-5p inhibitor and PIK3R3 overexpression reversed these effects.
CANCER CELL INTERNATIONAL
(2021)
Article
Computer Science, Artificial Intelligence
Yuhang Zhou, Shu-Wen Sun, Qiu-Ping Liu, Xun Xu, Ya Zhang, Yu-Dong Zhang
Summary: This paper proposes a Two-stage Expert-guided Diagnosis (TED) framework for MVI in HCC, which predicts key imaging attributes and leverages attention and soft supervision to improve the interpretability of the network.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Plant Sciences
Swetha Sudha Nagamalla, Malini Devi Alaparthi, Sunitha Mellacheruvu, Ravindar Gundeti, Jana Priya Sony Earrawandla, Someswar Rao Sagurthi
Summary: The study investigated the impact of drought stress on two cotton varieties, revealing that Bt cotton showed stronger drought tolerance compared to non-Bt cotton at the protein expression and physiological levels. This finding may aid in breeding new drought-tolerant and high-yielding cotton hybrid varieties.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemical Research Methods
Tanushree Halder, Elke Stroeher, Hui Liu, Yinglong Chen, Guijun Yan, Kadambot H. M. Siddique
Summary: Improving the root system of wheat is crucial for enhancing grain yield and climate resilience. This study identified proteins associated with root length and root mass in wheat using label-free quantitative proteomics. The findings revealed potential biomarkers that could be used for improving the root system of wheat.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Yinhua Pan, Quanqing Zou, Wu Yin, Zhen Huang, Yingzhu Zhao, Zongming Mo, Lihui Li, Jianrong Yang
Summary: A prognostic model of BC based on LNM-related genes was established in this study, providing guidance for prognosis evaluation and precise treatment of BC. The genes related to lymph node metastasis in BC are largely unknown and need further exploration. Searching for potential lymph node metastasis-related genes of BC will provide meaningful biomarkers for BC treatment. Our model, based on TCGA-BRCA data, effectively predicted patient outcomes and classified BC patients. The identified feature genes might have a predictive function in immunotherapy. The results of this study provide a new reference for the prognosis and treatment of BC patients with lymph node metastasis.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Qiushi Liang, Joon M. Pijnenburg, Erikjan Rijkers, Arnold G. Vulto, Ans T. van der Ploeg, Niek P. van Til, Eva C. Vlaar, Jeroen A. A. Demmers, W. W. M. Pim Pijnappel
Summary: Pompe disease is a lysosomal storage disorder characterized by glycogen accumulation in skeletal muscle, leading to profound pathology. This study showed that lentiviral gene therapy with LV-IGF2.GAAco can nearly completely correct disease-associated proteomic changes, supporting its future clinical development as a new treatment option for Pompe disease.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Chuang Liu, Wenjing Zhang, Qianli Dong, Haipeng Liu
Summary: This study fills the knowledge gap about the matrix proteins involved in the formation of mineralized exoskeletons in decapod crustaceans. By comparing with well-studied molluscan biomineralization proteins, it is proposed that decapod crustaceans evolved novel proteins while sharing some proteins with molluscs. This study provides insights into the evolution and adaptation of crustaceans and molluscs in forming their exoskeletons.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Rania D. Baka, Josipa Kules, Angelo Beletic, Vladimir Farkas, Dina Resetar Maslov, Blanka Beer Ljubic, Ivana Rubic, Vladimir Mrljak, Mark McLaughlin, David Eckersall, Zoe Polizopoulou
Summary: This study analyzed serum samples from dogs with epilepsy and identified potential markers of epilepsy, proteins involved in nerve tissue regeneration, and proteins altered by antiepileptic medication. The findings provide insight into the pathogenesis of epilepsy and the effects of medication on extracellular matrix proteins.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Viviane M. Codognoto, Fabiana F. de Souza, Thais R. Cataldi, Carlos A. Labate, Laiza S. de Camargo, Pedro H. Esteves Trindade, Roberto R. da Rosa Filho, Diego J. B. de Oliveira, Eunice Oba
Summary: This study aimed to compare urine proteomics from non- and pregnant buffaloes to identify potential biomarkers of early pregnancy. A total of 798 proteins were reported in the urine considering all groups, and the differential proteins play essential roles during pregnancy.
JOURNAL OF PROTEOMICS
(2024)