Journal
JOURNAL OF PROTEOME RESEARCH
Volume 12, Issue 4, Pages 1989-1995Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr301162j
Keywords
cross-linking; database; large scale data sets; protein interaction network; complex system; protein topology; data repository
Categories
Funding
- National Institutes of Health [R01RR023334, R01GM086688, R01GM097112, S10RR02510]
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As large-scale cross-linking data becomes available, new software tools for data processing and visualization are required to replace manual data analysis. XLink-DB serves as a data storage site and visualization tool for cross-linking results. XLink-DB accepts data generated with any cross-linker and stores them in a relational database. Cross-linked sites are automatically mapped onto PDB structures if available, and results are compared to existing protein interaction databases. A protein interaction network is also automatically generated for the entire data set. The XLink-DB server, including examples, and a help page are available for noncommercial use at http://brucelab.gs.washington.edu/crosslinkdbv1/. The source code can be viewed and downloaded at https://sourceforge.net/projects/crosslinkdb/?source=directory.
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