Article
Chemistry, Multidisciplinary
Hazrati Wazir, Shyan Yea Chay, Wan Zunairah Wan Ibadullah, Mohammad Zarei, Nor Afizah Mustapha, Nazamid Saari
Summary: The study suggests that storing low-moisture meat products at high temperatures can accelerate lipid and protein oxidation, while using MPET packaging and storing at low temperatures can effectively delay the oxidation process.
Article
Biochemistry & Molecular Biology
Veronika Paluchova, Tomas Cajka, Thierry Durand, Claire Vigor, Chandra Dodia, Shampa Chatterjee, Aron B. Fisher, Ondrej Kuda
Summary: Peroxiredoxin 6 (Prdx6) is a multifunctional enzyme that plays an important role in antioxidant defense and is linked to the biosynthesis of FAHFAs and various diseases. Deletion or mutation of Prdx6 affects the levels of FAHFAs, with different mutations having varying effects on FAHFA levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Neurosciences
Wei Qin, Wenwen Li, Qi Wang, Min Gong, Tingting Li, Yuqing Shi, Yang Song, Ying Li, Fangyu Li, Jianping Jia
Summary: The relationship between APOE genotypes and Alzheimer's disease varies among different races, providing insight into precision medicine for Alzheimer's disease across diverse populations.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemical Research Methods
Paige E. Lawler, James G. Bollinger, Suzanne E. Schindler, Cynthia R. Hodge, Nicolas J. Iglesias, Vishal Krishnan, John B. Coulton, Iran Li, David M. Holtzman, Randall J. Bateman
Summary: Although the APOE 4 allele is highly associated with sporadic Alzheimer's disease, the mechanism of apolipoprotein (apoE) and AD pathophysiology remains unclear. This study developed a LC-MS/MS assay to measure both unmodified and O-glycosylated apoE peptides in plasma and cerebrospinal fluid (CSF). The results indicate that plasma apoE glycosylation levels correlate with total apoE levels, APOE genotype, and amyloid status, suggesting it could be a marker of brain amyloidosis and may contribute to the pathophysiology of AD.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Claire J. C. Huguenard, Adam Cseresznye, Teresa Darcey, Aurore Nkiliza, James E. E. Evans, Stanley L. L. Hazen, Michael Mullan, Fiona Crawford, Laila Abdullah
Summary: With age and the APOE E4 allele, there are disturbances in the lipid bioenergetics pathways in Alzheimer's disease (AD). This study found that in aging mice, the APOE genotype affected the L-carnitine system, which is important for lipid bioenergetics, in the brain and periphery. The presence of the E4 allele and aging may contribute to AD pathogenesis through alterations in the L-carnitine bioenergetic system and cerebrovascular dysfunctions.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Ziyi Zhang, William Robert Kwapong, Le Cao, Zijuan Feng, Bo Wu, Junfeng Liu, Shuting Zhang
Summary: Early identification of APOE-related microvascular pathology is important for studying its contribution to Alzheimer's disease and finding therapeutic targets. Retinal microvasculature parameters differ between APOE e4 carriers and non-carriers, and cognitive impairment is associated with reduced microvascular densities.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Astrid Suchy-Dicey, Barbara Howard, W. T. Longstreth, Eric M. Reiman, Dedra Buchwald
Summary: This study found no evidence of an association between the APOE epsilon 4 allele and neurodegenerative risk in American Indians. Further research is needed to explore potential protective features.
ALZHEIMERS & DEMENTIA
(2022)
Article
Biochemistry & Molecular Biology
Barbora Salovska, Alexandra Kondelova, Kristyna Pimkova, Zuzana Liblova, Miroslav Pribyl, Ivo Fabrik, Jiri Bartek, Marie Vajrychova, Zdenek Hodny
Summary: This study reveals a novel role of PRDX6 in senescent cell viability and the development of senescence-associated secretory phenotype (SASP). It highlights the potential of PRDX6 as a drug target for senolytic or senomodulatory therapy.
Article
Geriatrics & Gerontology
Fengfeng Pan, Yifan Wang, Ying Wang, Xiaoming Wang, Yihui Guan, Fang Xie, Qihao Guo
Summary: Conflicting findings exist regarding the differences in amyloid burden and cognitive performance based on sex and APOE genotype. This study aimed to investigate the brain amyloid-beta (A beta) burden and cognitive performances by sex and APOE genotype in a cohort of A beta-positron emission tomography (PET)-positive participants. The results showed that females had higher A beta burden than males in APOE epsilon 4 noncarriers among cognitively normal participants, while APOE epsilon 4 carriers had higher A beta burden than noncarriers in males. In cognitively impaired participants, APOE epsilon 4 carriers were more likely to have higher A beta burden in specific brain regions.
NEUROBIOLOGY OF AGING
(2023)
Article
Biochemical Research Methods
Danting Liu, Shu Yang, Kanisha Kavdia, Jeffrey M. Sifford, Zhiping Wu, Boer Xie, Zhen Wang, Vishwajeeth R. Pagala, Hong Wang, Kaiwen Yu, Kaushik Kumar Dey, Anthony A. High, Geidy E. Serrano, Thomas G. Beach, Junmin Peng
Summary: A streamlined protocol has been developed to quantify over 9000 proteins with 0.5 μg of protein using 16-plex TMT coupled with LC/LC-MS/MS. Comparison with the standard protocol in 16 human brain tissue samples showed that the microgram-scale protocol had adequate sensitivity and reproducibility to detect differentially expressed proteins in disease-related pathways. This newly developed method holds promise for deep proteomic analysis at sub-microgram levels in biological and clinical samples.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Neurosciences
Dianxu Ren, Oscar L. Lopez, Jennifer H. Lingler, Yvette Conley
Summary: The study found that the APOE epsilon 2/epsilon 4 genotype is not significantly associated with the risk of Alzheimer's disease and mild cognitive impairment among African Americans.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Joseph O. Ojo, Jon M. Reed, Gogce Crynen, Prashanthi Vallabhaneni, James Evans, Benjamin Shackleton, Maximillian Eisenbaum, Charis Ringland, Anastasia Edsell, Michael Mullan, Fiona Crawford, Corbin Bachmeier
Summary: Cerebrovascular dysfunction is a key feature of Alzheimer's disease, with the APOE4 genotype impacting vascular amyloid clearance. Variations in APOE genotypes lead to different proteomic changes in cerebrovessels, with specific pathways affected by APOE4 carriers. The identified proteomic changes in association with APOE4 suggest potential novel targets for therapeutic strategies in mitigating AD pathogenesis.
Article
Fisheries
Chen Xu, Jie Yang, JiaJia Cao, Nan Jiang, Yong Zhou, Lingbing Zeng, Qiwang Zhong, Yuding Fan
Summary: This study investigated the protein levels in the spleen of rare minnow after infection with different genotypes of GCRV II using iTRAQ-based quantitative proteomics. The results showed that both virulent and attenuated isolates induced similar upregulated proteins related to ATP synthesis, while the virulent genotype induced more immunoproteins and increased levels of ubiquitin-proteasome system members. The DEPs in the attenuated infection group changed more quickly, indicating their sensitivity during virus infection.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Jihye Lee, Zhong Liu, Ying Gai Tusing, Chao Li, Erik Westin, Wei Li, Rui Zhao
Summary: iPSCs derived from B lymphocytes of two AD patients homozygous for the APOE e3 allele express pluripotency markers, possess the ability to differentiate into all three embryonic layers, and have normal karyotypes, making them valuable in vitro models for studying AD and evaluating new treatments.
STEM CELL RESEARCH
(2021)
Article
Clinical Neurology
Jori Tomassen, Anouk den Braber, Sven J. van der Lee, Lianne M. Reus, Elles Konijnenberg, Stephen F. Carter, Maqsood Yaqub, Bart N. M. van Berckel, Lyduine E. Collij, Dorret I. Boomsma, Eco J. C. de Geus, Philip Scheltens, Karl Herholz, Betty M. Tijms, Pieter Jelle Visser
Summary: This study investigated the associations between APOE genotype, AD-Polygenic Risk Scores (AD-PRS), amyloid-beta pathology, and cognitive decline in cognitively unimpaired older individuals. The results showed that APOE genotype was related to memory and language decline only in individuals with abnormal amyloid-beta. Additionally, other genetic risk variants contributed to memory decline independently of amyloid-beta status in initially cognitively unimpaired older individuals.
Article
Cell & Tissue Engineering
Ryan M. Jamiolkowski, Sa Do Kang, AnnMarie K. Rodriguez, Justin M. Haseltine, Lauren J. Galinat, Alexandra E. Jantzen, Tim A. Carlon, Marcus D. Darrabie, Antonio J. Arciniegas, Jose G. Mantilla, N. Rebecca Haley, Maria Noviani, Jason D. Allen, Thomas V. Stabler, James W. Frederiksen, Oscar Alzate, Lukas G. Keil, Siyao Liu, Fu-Hsiung Lin, George A. Truskey, Hardean E. Achneck
REGENERATIVE MEDICINE
(2015)
Article
Biochemistry & Molecular Biology
Sylvia Hiller, Robert DeKroon, Eric D. Hamlett, Longquan Xu, Cristina Osorio, Jennifer Robinette, Witold Winnik, Stephen Simington, Nobuyo Maeda, Oscar Alzate, Xianwen Yi
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2016)
Article
Biochemistry & Molecular Biology
Carrie E. Rubel, Jonathan C. Schisler, Eric D. Hamlett, Robert M. DeKroon, Mathias Gautel, Oscar Alzate, Cam Patterson
CELL BIOCHEMISTRY AND BIOPHYSICS
(2013)
Article
Biochemical Research Methods
Carolina Londono, Robert M. DeKroon, Mihaela Mocanu, Jessica Booe, Witold M. Winnik, Adam Swank, Cristina Osorio, Eric D. Hamlett, Oscar Alzate
Article
Biochemical Research Methods
Saria El Haddad, Marwan Khoury, Mohammad Daoud, Rami Kantar, Hayat Harati, Talal Mousallem, Oscar Alzate, Brian Meyer, Rose-Mary Boustany
Article
Biochemistry & Molecular Biology
Sergio Perez-Diaz, Lance A. Johnson, Robert M. DeKroon, Jose M. Moreno-Navarrete, Oscar Alzate, Jose M. Fernandez-Real, Nobuyo Maeda, Jose M. Arbones-Mainar
Article
Biochemistry & Molecular Biology
Sylvia Hiller, Robert DeKroon, Longquan Xu, Jennifer Robinette, Witold Winnik, Oscar Alzate, Stephen Simington, Nobuyo Maeda, Xianwen Yi
FREE RADICAL BIOLOGY AND MEDICINE
(2014)
Article
Biochemistry & Molecular Biology
Miguel A. Contreras, Oscar Alzate, Avtar K. Singh, Inderjit Singh
Article
Cell Biology
Rob U. Onyenwoke, Lawrence J. Forsberg, Lucy Liu, Tyisha Williams, Oscar Alzate, Jay E. Brenman
MOLECULAR BIOLOGY OF THE CELL
(2012)
Article
Cell Biology
Harold G. Klemcke, Robert M. DeKroon, Mihaela Mocanu, Jennifer B. Robinette, Oscar Alzate
PHYSIOLOGICAL GENOMICS
(2013)
Article
Pharmacology & Pharmacy
Jonathan H. Shannahan, Oscar Alzate, Witold M. Winnik, Debora Andrews, Mette C. Schladweiler, Andrew J. Ghio, Stephen H. Gavett, Urmila P. Kodavanti
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2012)
Article
Clinical Neurology
Oscar Alzate, Cristina Osorio, Robert M. DeKroon, Ana Corcimaru, Harsha P. Gunawardena
ALZHEIMERS RESEARCH & THERAPY
(2014)
Article
Environmental Sciences
Prasada Rao S. Kodavanti, Joyce E. Royland, Cristina Osorio, Witold M. Winnik, Pedro Ortiz, Lei Lei, Ram Ramabhadran, Oscar Alzate
ENVIRONMENTAL HEALTH PERSPECTIVES
(2015)
Review
Biochemistry & Molecular Biology
Carolina Londono, Cristina Osorio, Vivian Gama, Oscar Alzate
Article
Tropical Medicine
Luz E. Botero, Andres E. Toro, Alber J. Patino, Guillermo Salazar, Juan C. Rodriguez, Juan C. Suarez-Escudero, Gustavo A. Alarcon, Ana Corcimaru, Cristina Osorio, Joseph S. Y. Jeong, Oscar Alzate