Putting the Squeeze on Airway Epithelia

A molecular mechanotransduction pathway regulates collective migration of epithelial cells

(2015) Tamal Das et al.   NATURE CELL BIOLOGY

Control of cell–cell forces and collective cell dynamics by the intercellular adhesome

(2015) Elsa Bazellières et al.   NATURE CELL BIOLOGY

EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production

(2014) April Kalinowski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Asthmatic and Normal Respiratory Epithelial Cells Respond Differently to Mechanical Apical Stress

(2014) Christopher Grainge et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

CHI3L1polymorphisms associate with asthma in a Taiwanese population

(2014) Yishan Tsai et al.   BMC Medical Genetics

Cellular and physical mechanisms of branching morphogenesis

(2014) Victor D. Varner et al.   DEVELOPMENT

Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice

(2013) Jin-Ah Park et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The plasminogen activation system: new targets in lung inflammation and remodeling

(2013) Michael Schuliga et al.   CURRENT OPINION IN PHARMACOLOGY

Collective migration and cell jamming

(2013) Monirosadat Sadati et al.   DIFFERENTIATION

Respiratory virus–induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium

(2013) Iris F. Ueki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Propulsion and navigation within the advancing monolayer sheet

(2013) Jae Hun Kim et al.   NATURE MATERIALS

Ventilator-Induced Lung Injury

(2013) Arthur S. Slutsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Monolayer Stress Microscopy: Limitations, Artifacts, and Accuracy of Recovered Intercellular Stresses

(2013) Dhananjay T. Tambe et al.   PLoS One

Bronchoalveolar lavage fluid exosomes contribute to cytokine and leukotriene production in allergic asthma

(2012) P. Torregrosa Paredes et al.   ALLERGY

Role of YKL-40 in Bronchial Smooth Muscle Remodeling in Asthma

(2012) Imane Bara et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Histamine may induce airway remodeling through release of epidermal growth factor receptor ligands from bronchial epithelial cells

(2012) Nobuaki Hirota et al.   FASEB JOURNAL

Tissue factor–bearing exosome secretion from human mechanically stimulated bronchial epithelial cells in vitro and in vivo

(2012) Jin-Ah Park et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Airway epithelial cells from asthmatic children differentially express proremodeling factors

(2012) Jesus M. Lopez-Guisa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

Mechanical waves during tissue expansion

(2012) Xavier Serra-Picamal et al.   Nature Physics

Physical Biology Returns to Morphogenesis

(2012) R. Keller   SCIENCE

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

A Mechanoresponsive Cadherin-Keratin Complex Directs Polarized Protrusive Behavior and Collective Cell Migration

(2011) Gregory F. Weber et al.   DEVELOPMENTAL CELL

The sentinel role of the airway epithelium in asthma pathogenesis

(2011) Stephen T. Holgate   IMMUNOLOGICAL REVIEWS

What effect does asthma treatment have on airway remodeling? Current perspectives

(2011) Sheharyar R. Durrani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic review of observational studies

(2011) Susannah Fleming et al.   LANCET

A YKL-40-Neutralizing Antibody Blocks Tumor Angiogenesis and Progression: A Potential Therapeutic Agent in Cancers

(2011) M. Faibish et al.   MOLECULAR CANCER THERAPEUTICS

Jamming by shear

(2011) Dapeng Bi et al.   NATURE

Collective cell guidance by cooperative intercellular forces

(2011) Dhananjay T. Tambe et al.   NATURE MATERIALS

Integrated morphodynamic signalling of the mammary gland

(2011) Nikolce Gjorevski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Physical Forces and Airway Remodeling in Asthma

(2011) Daniel J. Tschumperlin   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Bronchoconstriction on Airway Remodeling in Asthma

(2011) Christopher L. Grainge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dynamic heterogeneity comes to life

(2011) J. P. Garrahan   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glass-like dynamics of collective cell migration

(2011) T. E. Angelini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium

(2011) Ceri E Stewart et al.   THORAX

Plithotaxis and emergent dynamics in collective cellular migration

(2011) Xavier Trepat et al.   TRENDS IN CELL BIOLOGY

TNF-α–Converting Enzyme/A Disintegrin and Metalloprotease−17 Mediates Mechanotransduction in Murine Tracheal Epithelial Cells

(2010) Tetsuya Shiomi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Influence of Transmural Pressure and Cytoskeletal Structure on NF-κB Activation in Respiratory Epithelial Cells

(2010) Yan Huang et al.   Cellular and Molecular Bioengineering

Airway remodeling in asthma

(2010) Rabih Halwani et al.   CURRENT OPINION IN PHARMACOLOGY

An EGFR autocrine loop encodes a slow-reacting but dominant mode of mechanotransduction in a polarized epithelium

(2010) Nikola Kojic et al.   FASEB JOURNAL

Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration

(2010) Julia Esser et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Chitinase-like Protein YKL-40 Is Secreted by Airway Epithelial Cells at Base Line and in Response to Compressive Mechanical Stress

(2010) Jin-Ah Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Airway Mucus Function and Dysfunction

(2010) John V. Fahy et al.   NEW ENGLAND JOURNAL OF MEDICINE

The physical basis of ventilator-induced lung injury

(2010) Maria Plataki et al.   Expert Review of Respiratory Medicine

Chronic Intermittent Mechanical Stress Increases MUC5AC Protein Expression

(2009) Jin-Ah Park et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Advances in Mucous Cell Metaplasia

(2009) David R. Curran et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Characterisation of urokinase plasminogen activator receptor variants in human airway and peripheral cells

(2009) Ceri E Stewart et al.   BMC MOLECULAR BIOLOGY

Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma

(2009) Margaret M. Kelly et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Physical forces during collective cell migration

(2009) Xavier Trepat et al.   Nature Physics

Collective cell migration in morphogenesis, regeneration and cancer

(2009) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

YKL-40, a secreted glycoprotein, promotes tumor angiogenesis

(2009) R Shao et al.   ONCOGENE

Association of Polymorphisms of the CHI3L1 Gene with Asthma and Atopy: A Populations-Based Study of 6514 Danish Adults

(2009) Camilla Noelle Rathcke et al.   PLoS One

Genetic Variation in the Promoter Region ofChitinase 3-Like 1Is Associated with Atopy

(2008) Myung Hyun Sohn et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of Variation inCHI3L1on Serum YKL-40 Level, Risk of Asthma, and Lung Function

(2008) Carole Ober et al.   NEW ENGLAND JOURNAL OF MEDICINE