Article
Chemistry, Multidisciplinary
Robert Malmberg, Dominik Suter, Olivier Blacque, Koushik Venkatesan
Summary: The synthesis, characterization, and photoluminescent properties of four cyclometalated (C N)-type gold(III) complexes with a bidentate diacetylide ligand were reported. These complexes exhibit highly tunable excited state properties and remarkable singlet oxygen generation capability.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Multidisciplinary Sciences
Denisse Fuentes-Lopez, Daniel Ortega-Zambrano, Maria Antonieta Fernandez-Herrera, Hilda Mercado-Uribe
Summary: Photodynamic inactivation is a promising method that utilizes photosensitizers to generate reactive oxygen species and inhibit the growth of pathogenic microorganisms. In this study, pheomelanin nanoparticles were used as sensitizers to successfully inhibit the growth of E. coli. The results suggest that this method is effective against E. coli and could potentially be applied to other bacteria.
Article
Chemistry, Medicinal
Guangyu Lin, Mei Hu, Rong Zhang, Yuanxing Zhu, Kedan Gu, Junping Bai, Jiyang Li, Xiaochun Dong, Weili Zhao
Summary: Antimicrobial photodynamic therapy (aPDT) is a promising approach for treating pathogenic microorganism infections, with a methyl meso-(meta-pyridinium) BODIPY photosensitizer demonstrating the highest phototoxicity and impressive antimicrobial efficacy.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
P. Leighton, C. Silva, S. A. Sanchez, J. Morales, C. Sandoval-Altamirano, G. Gunther
Summary: Carbohydrates play important roles in biological processes and technological applications. Carbohydrate-based surfactants, despite their physicochemical restrictions, have low toxicity and environmental friendliness. This study focuses on a mixed micelle system composed of new synthesized glycolipids that can generate singlet oxygen and interact with lectins, offering a promising system for antibacterial photodynamic therapy.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Gulsah Gumrukcu Kose, Gulnur Keser Karaoglan
Summary: This study is based on photodynamic therapy (PDT) and sonophotodynamic therapy (SPDT) which combines photochemical and sonochemical studies, produces high singlet oxygen and provides more effective therapeutic results in the treatment of cancer. For this purpose, a new photosensitizer, naphthoic acid substituted silicon phthalocyanine, is synthesized and characterized by elemental analysis, 1H NMR, FT-IR, MALDI-TOF MS and UV-Vis spectral data and its photophysico-chemical properties are investigated. The results show that sonophotochemical study remarkably increased the therapeutic effect, which is important in cancer treatment.
Article
Biochemistry & Molecular Biology
David Steinebrunner, Guenter Schnurpfeil, Hans Hannes Doebler, Jorge Adrian Tapia Burgos, Dieter Woehrle, Arne Wittstock
Summary: This study demonstrates the versatility of functionalized nanoporous gold with a photosensitizer for photocatalytic oxidation reactions using different substrates and solvents. Immobilization of the sensitizer onto nanoporous gold enhances conversion rates, except for the largest substrate (ergosterol).
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2021)
Article
Chemistry, Applied
Goknur Yasa Atmaca, Ceren Can Karanlik, Ali Erdogmus
Summary: Singlet oxygen quantum yields of new indium phthlocyanines were higher when synthesized through sono-photochemical methods compared to photochemical methods. The results suggest that sono-photochemical methods improve therapeutic activity in comparison to photochemical methods.
Article
Chemistry, Applied
Joanna Szymczak, Tomasz Rebis, Michal Kotkowiak, Barbara Wicher, Lukasz Sobotta, Ewa Tykarska, Jadwiga Mielcarek, Michal Kryjewski
Summary: Three regioisomers of L-menthol-substituted magnesium(II) phthalocyanine were obtained and characterized, with one of them having its crystal structure determined. The compounds exhibited maxima in the Q-band, varying quantum yields for fluorescence and singlet oxygen generation, as well as specific oxidation and reduction behaviors in voltammetric studies. DFT methods were used to calculate IR and UV-Vis spectra and optical band gap.
Article
Pharmacology & Pharmacy
Daniel Ziental, Dariusz T. Mlynarczyk, Emil Kolasinski, Emre Guzel, Jolanta Dlugaszewska, Lukasz Popenda, Stefan Jurga, Tomasz Goslinski, Lukasz Sobotta
Summary: Phthalocyanines have been widely used as photosensitizers in photodynamic antimicrobial therapy (PACT) due to their superior properties. In this study, zinc(II) and palladium(II) phthalocyanine complexes were synthesized and characterized. The palladium(II) complex showed the highest bactericidal activity against antibiotic-resistant microorganisms.
Article
Biochemistry & Molecular Biology
Evgeniya A. Safonova, Filipp M. Kolomeychuk, Daniil A. Gvozdev, Aslan Yu. Tsivadze, Yulia G. Gorbunova
Summary: This study demonstrated, for the first time, the efficient singlet oxygen (SO) generation ability of P(V) phthalocyanines (Pcs), specifically unsubstituted and alpha- and beta-octabutoxy-substituted P(V)Pcs. The photophysical and photochemical properties of these compounds can be fine-tuned by varying the substituents in the Pc ring and P(V) axial ligands. The introduction of electron-donating butoxy groups, especially in the alpha-position, increased the photostability of P(V)Pcs. Furthermore, the photostability depended on the nature of axial ligands, with higher stability observed in the order of OPh < OMe < OH for beta-BuO-substituted P(V)Pcs.
Article
Chemistry, Physical
Goknur Yasa Atmaca
Summary: This study successfully synthesized a compound with improved photochemical properties and measured its singlet oxygen efficiency in DMSO and DMF through sono-photochemical studies. The designed complex exhibited remarkably high singlet oxygen quantum yields, indicating that sono-photodynamic therapy can enhance therapeutic activity.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Estefania Baigorria, Javier E. Durantini, Maria A. Di Palma, Natalia S. Gsponer, Maria E. Milanesio, Edgardo N. Durantini
Summary: A novel tricationic Zn(II)phthalocyanine derivative, (NCH3)(3)ZnPc3+, was synthesized and found to exhibit promising potential in photodynamic activity and antimicrobial phototherapy through comparison of its properties.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2021)
Article
Spectroscopy
Halit Kantekin, Gulpinar Sarki, Ipek Omeroglu, Halise Yalazan, Nuran Kahriman, Mahmut Durmus
Summary: Novel metallo phthalocyanine derivatives with chalcone groups were synthesized and characterized using spectroscopic techniques. The photophysical and photochemical properties of the compounds in DMSO were investigated, showing no aggregation of phthalocyanine complexes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Physical
Zehra Kazancicok, Hatice Esar Guler, Mucahit Ozdemir, Mehmet Piskin, Mustafa Bulut, Bahattin Yalcin, Umit Salan
Summary: Peripheral and non-peripheral substituted Zn(II) phthalocyanine complexes were synthesized from 7-hydroxy-3-(p-tolyl)coumarin and 7-hydroxy-3-(p-tosyl)coumarin compounds. The newly synthesized compounds were characterized and their solubility and fluorescence quenching behavior were investigated. The photophysical and photochemical properties of the phthalocyanines were examined, and the coumarin-phthalocyanine complexes containing tolyl-/tosyl-groups showed potential for use in photodynamic therapy.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Govind Reddy, Enrico Della Gaspera, Lathe A. Jones, Lingamallu Giribabu
Summary: Phthalocyanine (Pc) molecules have been studied as photosensitizers for singlet oxygen generation, especially for applications like photodynamic therapy due to their intense absorption bands in the near-infrared region. A symmetrical Zn(II) phthalocyanine (PC-1) with good thermal stability and appropriate energy levels was designed and converted into hydrophilic nanoparticles with good water dispersability. Optical studies showed a shift in absorbance in the NIR region and singlet oxygen generation, making PC-1 a potential candidate for photoinduced oxidative processes in biological and catalytic applications.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Optics
A. S. Kozlov, O. N. Egorova, O. Medvedkov, A. A. Krasnovsky
Summary: The study observed population of the chemically active singlet state of molecular oxygen through direct laser excitation, using a chemical trapping method and spectroscopic analysis to monitor the generation of singlet oxygen. The results are important for both spectroscopy of oxygen and mechanistic studies of biological and therapeutic action of laser radiation.
Article
Optics
A. S. Benditkis, A. S. Kozlov, S. E. Goncharov, A. A. Krasnovsky
Summary: The study focused on IR phosphorescence and chemical trapping of oxygen in aerated organic solvents under laser irradiation, comparing the absorption spectra of dissolved oxygen molecules at different excitation wavelengths. The experiments revealed the presence of complexes that were more photoactive than oxygen molecules themselves. Phosphorescence of singlet oxygen was weaker under excitation at 690 nm compared to 765 nm, with linear dependence on excitation power and enhancement in solvents containing heavy atoms. The data provided evidence that the phosphorescence at 690 nm was due to excitation of the Fraunhofer band B in the oxygen absorption spectrum, with estimated molar absorption coefficients in aerated solvents lacking heavy atoms.
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Antonina Klimenko, Elvira E. Rodina, Denis Silachev, Maria Begun, Valentina A. Babenko, Anton S. Benditkis, Anton S. Kozlov, Alexander A. Krasnovsky, Yuri S. Khotimchenko, Vladimir L. Katanaev
Summary: Photodynamic therapy (PDT) is a powerful anticancer treatment that relies on the use of photosensitizers. This study identifies ETPA as a major metabolite of the North Pacific brittle stars and demonstrates its strong phototoxicity against cancer cell lines in vitro. In a mouse model of glioblastoma, ETPA injection combined with red laser irradiation induces necrotic ablation of the brain tumor.
Article
Optics
P. N. Antokhin, V. G. Arshinova, M. Yu Arshinov, B. D. Belan, S. B. Belan, L. P. Golobokova, D. K. Davydov, G. A. Ivlev, A. Kozlov, A. S. Kozlov, V. Otmakhov, T. M. Rasskazchikova, D. Simonenkov, G. N. Tolmachev, A. Fofonov
Summary: Airborne sensing data are used to study the change in air composition during the transition from the troposphere to the stratosphere. The study shows significant differences in the concentrations of different gases and particles, as well as variations in composition between different atmospheric layers.
ATMOSPHERIC AND OCEANIC OPTICS
(2021)
Article
Physics, Multidisciplinary
A. A. Krasnovsky, A. S. Kozlov, A. S. Benditkis
Summary: The results of studies on the photochemical activity and phosphorescence of oxygen molecules upon direct laser excitation in aerated organic solvents and water are summarized in this paper. The absorption spectra of dissolved oxygen in these media, obtained at normal pressure and temperature in the range of 600-1300 nm, are of fundamental importance for understanding the spectroscopy of molecular oxygen and its role as a photoreceptor triggering the biological action of laser radiation.
RUSSIAN PHYSICS JOURNAL
(2022)
Article
Virology
Vladimir Zhukhovitsky, Natalia Shevlyagina, Margarita Zubasheva, Leonid Russu, Vladimir Gushchin, Gennady Meerovich, Marina Strakhovskaya
Summary: This study investigated the reduction of bovine coronaviruses (BCoVs) and the morphological changes in viral particles using photodynamic inactivation. The results showed that methylene blue and octakis(cholinyl)zinc phthalocyanine, combined with LED light sources, significantly decreased BCoV titers and led to changes in the morphology of viral particles.
Article
Biochemistry & Molecular Biology
Vladimir Fedorov, Ekaterina Kholina, Sergei Khruschev, Ilya Kovalenko, Andrew Rubin, Marina Strakhovskaya
Summary: Electrostatics is crucial for the activities of viruses. We used a coarse-grained model to create an electrostatic map of the surface of SARS-CoV-2 and found that the distribution of charges is highly heterogeneous. Negatively charged lipid domains in the viral membrane and negatively charged regions on the spike proteins contribute to the negative patches. Membrane and envelope proteins with positive charges tend to colocalize with the negatively charged lipids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biophysics
Larissa A. Koppel, Alexander A. Krasnovsky Jr
BIOPHYSICAL REVIEWS
(2022)
Article
Optics
Daniil A. Gvozdev, Alexei E. Solovchenko, Alexander G. Martynov, Aleksei Yagodin, Marina G. Strakhovskaya, Yulia G. Gorbunova, Eugene G. Maksimov
Summary: The study found that conjugating photosensitizer molecules with nanoparticles can change the spectral properties of photosensitizers, and concentration effects can lead to aggregation and nonradiative energy transfer. These processes can decrease the number of photosensitizer molecules in an excited state.
Article
Biochemistry & Molecular Biology
Alexander M. Firsov, Juergen Pfeffermann, Anton S. Benditkis, Tatyana I. Rokitskaya, Anton S. Kozlov, Elena A. Kotova, Alexander A. Krasnovsky, Peter Pohl, Yuri N. Antonenko
Summary: The goal of developing chemical compounds that can mimic the functions of biological molecular machineries has resulted in the creation of various artificial molecular motors (AMMs). These photoexcited monomolecular unidirectionally-rotating AMMs have been seen as potentially useful in pharmaceutical applications due to their ability to permeabilize biological membranes. However, the mechanical properties of lipid membranes cast doubt on the proposed drilling activity of AMMs. In this study, it was discovered that singlet oxygen released by a photoexcited molecular drill could oxidize unsaturated lipids in giant unilamellar vesicles, while liposomes made of saturated lipids remained unaffected. Further experiments showed that rather than mechanically destroying ion channels in lipid membranes, the AMMs photoinactivated them. This study suggests that the envisioned therapeutic and pharmaceutical applications of AMMs rely more on their photodynamic activity than their nanomechanical drilling abilities.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Optics
I. S. Andreeva, O. A. Baturina, A. S. Safatov, N. A. Solovyanova, T. Y. Alikina, L. Puchkova, M. E. Rebus, G. A. Buryak, S. E. Olkin, A. S. Kozlov, M. R. Kabilov
Summary: Microorganisms in atmospheric aerosols were analyzed in four sites with different anthropogenic load in Novosibirsk. The study found that spore-forming bacteria of the genus Bacillus and cocci of the genera Staphylococcus and Micrococcus were predominant in winter samples, while the concentrations and diversity of different bacteria, actinomycetes, and fungi sharply increased in spring-summer and autumn samples. Furthermore, a significant number of antibiotic-resistant hemolytic spore-forming bacteria and staphylococci with enzymes contributing to the development of infectious processes were identified.
ATMOSPHERIC AND OCEANIC OPTICS
(2022)
Article
Biochemistry & Molecular Biology
Ilya Kovalenko, Ekaterina Kholina, Vladimir Fedorov, Sergei Khruschev, Ekaterina Vasyuchenko, Gennady Meerovich, Marina Strakhovskaya
Summary: This study used Brownian dynamics to study the binding mechanism of methylene blue with the SARS-CoV-2 envelope. Methylene blue targets the S and E proteins and negatively charged lipids of the virus, inhibiting different stages of the virus life cycle. The results of this study contribute to the understanding of the molecular basis of methylene blue's antiviral activity against coronaviruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Optics
M. Yu Arshinov, V. G. Arshinova, B. D. Belan, D. K. Davydov, G. A. Ivlev, A. S. Kozlov, L. Kuibida, T. M. Rasskazchikova, D. Simonenkov, G. N. Tolmachev, A. Fofonov
Summary: The anomalous vertical distribution of organic aerosol on September 14, 2018, was analyzed based on aircraft sounding data, showing a significant increase in maximal concentration in the boundary layer compared to previous measurements. The contribution of aerosols from different origins to total concentration in different tropospheric layers was estimated, with potential sources identified in boreal forests and industrial infrastructure.
ATMOSPHERIC AND OCEANIC OPTICS
(2021)
