Journal
JOURNAL OF POROUS MATERIALS
Volume 18, Issue 2, Pages 233-239Publisher
SPRINGER
DOI: 10.1007/s10934-010-9375-3
Keywords
Mesoporous silica nanoparticles; Drug storage; Pulsed pressure drop; Drug delivery
Funding
- National Natural Science Foundation of China [20673037, 20973058]
- Commission of Science and Technology of Shanghai Municipality [08JC1407900]
- East China University of Science and Technology, China
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Mesoporous silica nanoparticles (MSN) have been synthesized at room temperature under assistance of n-hexane by using tetraethyl orthosilicate (TEOS) as a silica source and cetyltrimethylammonium bromide (CTAB) as a structure directing agent. Powder X-ray diffraction studies showed that the quantity of n-hexane added into the solution was critical for the ordering of the final mesostructures. The particle size of MSN was between 200 and 400 nm, which is suitable for endocytosis by human cells. The drug loading capability of MSN prepared through this route was measured and the influence of the pulsed pressure drop on drug delivery was studied. This study showed that the delivery rate of ibuprofen in a simulated body fluid solution increased dramatically under the pulsed pressure drop.
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