Article
Pharmacology & Pharmacy
Sumbal Talib, Naveed Ahmed, Dildar Khan, Gul Majid Khan, Asim Ur Rehman
Summary: The study successfully developed artemether-loaded biopolymeric nanoparticles and loaded them into transdermal patches. The nanoparticles had small particle size and good stability, with release rate controlled by diffusion. Transdermal drug delivery route showed improved drug permeability with the presence of a permeation enhancer.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Linh Dinh, Soohun Lee, Sharif Md Abuzar, Heejun Park, Sung-Joo Hwang
Summary: A new method for transdermal delivery of donepezil was developed using a drug-in-adhesive patch. The synthesized ionic liquid (IL) showed inhibition of crystallization and excellent skin permeability.
Article
Pharmacology & Pharmacy
Putri Wulandari Resky Ananda, Diany Elim, Hilman Syamami Zaman, Wahdaniyah Muslimin, Muhamad Gilang Ramadhan Tunggeng, Andi Dian Permana
Summary: Malaria caused by various Plasmodium strains is a global health issue, and developing effective treatment methods is crucial. This study formulated primaquine into a transdermal patch for the first time, demonstrating good bioadhesive and permeation properties through various evaluations. Additionally, the transdermal patch showed promising drug release and permeation profiles in ex vivo studies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Thiruvenkadasamy R. Poorani, Selvam Iswarya, Mythili Priya, Sri D. Sivakumar, S. Kannan
Summary: The use of silver in healthcare has become more advantageous with the advancement of nanotechnology, particularly in the fabrication of silver nanoparticles. These nanoparticles have shown promising applications in controlled drug release, especially in biomedical fields.
MINERVA BIOTECHNOLOGY AND BIOMOLECULAR RESEARCH
(2021)
Article
Chemistry, Physical
Nitinon Viratchaiboott, Phimchanok Sakunpongpitiporn, Sumonman Niamlang, Anuvat Sirivat
Summary: In this study, porous PBSA matrices and magnetic nanoparticles were used for transdermal drug delivery. The results demonstrate that under the influence of magnetic and electric fields, the drug diffusion coefficient increased and the drug release duration was reduced.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Engineering, Biomedical
Ahlam Zaid Alkilani, Batool Musleh, Rania Hamed, Lubna Swellmeen, Haneen A. Basheer
Summary: This study aimed to design transdermal patch-embedded niosomes loaded with clarithromycin (CLR) to overcome its gastrointestinal tract side effects and bitter taste. The niosomal patch showed higher permeability coefficient and better antibacterial activity compared to conventional patch, indicating its potential as a promising method for transdermal drug delivery.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Biophysics
Nur Farrahain Nadia Ahmad, Nik Nazri Nik Ghazali, Yew Hoong Wong
Summary: The review discusses advanced stimuli-responsive approaches and the evolution of wearable patch pumps, highlighting key challenges and future development trends in controllable transdermal drug delivery systems. Various advanced delivery strategies and mechanisms, including mechanical, electrical, light, thermal, acoustic, and glucose-responsive approaches, are summarized with representative examples.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biochemistry & Molecular Biology
Farida Akhatova, Svetlana Konnova, Marina Kryuchkova, Svetlana Batasheva, Kristina Mazurova, Anna Vikulina, Dmitry Volodkin, Elvira Rozhina
Summary: Synthesis of silver nanoparticles using plant extracts is a viable alternative to traditional methods, offering simplicity, affordability, and environmentally friendly processes. This study successfully produced silver and iron nanoparticles using sphagnum extract and traditional methods. Various techniques, including DLS, UV-visible spectroscopy, TEM with EDS, AFM, dark-field hyperspectral microscopy, and FT-IR, were employed to analyze the structure and properties of the synthesized nanoparticles. The findings demonstrated strong antibacterial activity, including biofilm formation, and suggested the potential for further research on nanoparticles synthesized using sphagnum moss extracts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Shinya Kusama, Kaito Sato, Yuuya Matsui, Natsumi Kimura, Hiroya Abe, Shotaro Yoshida, Matsuhiko Nishizawa
Summary: The authors discuss the utilization of porous polymer microneedles combined with electroosmosis powered by enzymatic batteries to deliver small and large molecules across the skin efficiently.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Rabab A. Dorgham, Mohamed N. Abd Al Moaty, Khim Phin Chong, Bassma H. Elwakil
Summary: Silver nanoparticles synthesized using molasses were found to have promising antimicrobial activity against biofilms, with molasses concentration being the main factor affecting their performance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Li Zhao, Lalitkumar K. Vora, Stephen A. Kelly, Linlin Li, Eneko Larraneta, Helen O. McCarthy, Ryan F. Donnelly
Summary: Antibiotic resistance is a serious health problem and is expected to worsen in the future. Researchers have developed a hydrogel-forming microarray patch system that can deliver antibiotics in a sustained manner.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Hitesh Kumar Dewangan, Suman Tomar
Summary: Studies have shown that nanovaccines have higher immunogenicity and stability, reducing immunotolerance and eliminating the need for regular vaccinations. They can improve cell-mediated and antibody-mediated immunity as well as immunologic memory, and have important implications for various pathological conditions.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yu Cai, Qi Tian, Chao Liu, Liang Fang
Summary: The study successfully developed a long-acting drug-in-adhesive patch of rivastigmine with controlled and stable drug release achieved through optimized formulation. This provides a new concept for long-term drug delivery in Alzheimer's disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Chemistry, Analytical
Muhammet Avcil, Ayhan Celik
Summary: The innovative transdermal delivery technology of microneedle patch has great potential for various applications, but also faces limitations that need to be addressed for further improvements. Scientists and technologists should be aware of these concerns and allocate resources wisely.
Article
Medicine, General & Internal
Jin-Ho Joo
Summary: In this case report, anisocoria following contamination with a scopolamine transdermal patch was successfully diagnosed and managed through the application of medications, observation, and exclusion of other possible etiologies. The patient's pupil size gradually decreased to normal levels with artificial tears and monitoring, highlighting the importance of a thorough history and systematic diagnostic approach in managing cases of anisocoria.
Article
Pharmacology & Pharmacy
Wiwat Pichayakorn, Chaowalit Monton, Yupaporn Sampaopan, Kamon Panrat, Jirapornchai Suksaeree
Summary: This study successfully prepared buccal film using a self-emulsifying system for L. strychnifolium stem extracts. The film showed an amorphous state and could be placed in direct contact with the mouth. The release mechanism of the film was swelling and diffusion.
Article
Engineering, Environmental
Wiwat Pichayakorn, Pattwat Maneewattanapinyo, Kamon Panrat, Chaowalit Monton, Jirapornchai Suksaeree
Summary: This study prepared oral strip-films for nicotine delivery using specific materials and optimized their characteristics. The release and permeation of nicotine from the films were found to be dependent on the amount of specific components. The results provide important insights for the development of nicotine oral strip-films.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Pharmacology & Pharmacy
Jirapornchai Suksaeree, Chaowalit Monton, Laksana Charoenchai, Natawat Chankana, Thaniya Wunnakup
Summary: This study successfully developed SHPN extract effervescent tablets with desired properties that were easy to use, and the time needed to disintegrate the active ingredients was decreased compared with the traditional dosage form.
Article
Pharmacology & Pharmacy
Pattwat Maneewattanapinyo, Chaowalit Monton, Wiwat Pichayakorn, Nattakan Dangmanee, Thaniya Wunnakup, Jirapornchai Suksaeree
Summary: Traditional Asian remedies often use Ganoderma applanatum, a macrofungus, as a medicinal mushroom due to its strong antibacterial and antioxidant properties. This fungus can be synthesized into nanoparticles and made into plaster gels. The synthesized silver nanoparticle-mediated G.applanatum has been found to effectively inhibit bacterial growth. When applied to the skin, the gel turns into a film, making it suitable for topical pharmaceutical delivery.
Article
Pharmacology & Pharmacy
Pattwat Maneewattanapinyo, Wiwat Pichayakorn, Chaowalit Monton, Nattakan Dangmanee, Thaniya Wunnakup, Jirapornchai Suksaeree
Summary: In this study, the effect of 1-butyl-3-methylimidazolium bromide-based ionic liquid on the silver nanoparticle-complexed Ganoderma applanatum and its topical film was investigated. The optimal ratio of silver nanoparticles: G. applanatum extract: ionic liquid was 97:1:2, and the conditions were 80 °C for 1 hour. The topical film made of polyvinyl alcohol and Eudragit((R)) loaded with the optimized formula showed desirable properties and improved skin permeability.
Article
Polymer Science
Napaphol Puyathorn, Nutdanai Lertsuphotvanit, Takron Chantadee, Wiwat Pichayakorn, Thawatchai Phaechamud
Summary: In this study, lincomycin HCl-loaded in situ forming gels (ISGs) were developed using a 40% borneol-based matrix and N-methyl pyrrolidone (NMP) as a solvent. The ISGs exhibited low viscosity and reduced surface tension, allowing for easy injection and spreadability. The drug-loading influenced solvent exchange and matrix formation, resulting in thinner and inhomogeneous borneol matrices with slower gel formation and lower gel hardness. These lincomycin HCl-loaded ISGs demonstrated sustained drug release and showed dose-dependent inhibition against various bacteria, making them promising for localized drug delivery systems for periodontitis treatment.
Article
Pharmacology & Pharmacy
Jirapornchai Suksaeree, Chaowalit Monton, Laksana Charoenchai, Natawat Chankana
Summary: This study aimed to optimize the microwave-assisted drying of PSKP granules using DOE and develop a formulation for PSKP tablets. The optimal condition for microwave drying was found to be 300 W of microwave power for 15 min. This condition was then used to dry the wet granules and optimize the tablet formulation. The optimal parameters for tablet formulation were 1500 psi of compression force, 4.5% of polyvinyl pyrrolidone K30, and 2% of sodium starch glycolate. The optimal tablets showed rapid dissolution. In conclusion, this work successfully applied DOE for PSKP granule drying and formulation development of tablets.
ADVANCES IN TRADITIONAL MEDICINE
(2023)
Article
Plant Sciences
Chaowalit Monton, Thanchanok Tanpao, Chunyaphat Navakul, Thanittha Pengkum, Supadit Santasanasuwan, Jirapornchai Suksaeree, Laksana Charoenchai, Thanapat Songsak
Summary: In Thailand, cannabis cultivation and trade have become more lenient recently, leading to increased availability. However, misuse of cannabis has been observed among certain user groups. This study analyzed the cannabinoids content in 14 samples of Cannabis sativa claimed to be a specific cultivar cultivated in outdoor settings across Thailand. The results showed that these samples contained a high concentration of A9-THC.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Green & Sustainable Science & Technology
Jirapornchai Suksaeree, Chanin Bumroongrat, Nantanat Polraksa, Wirach Taweepreda, Thawatchai Phaechamud, Wiwat Pichayakorn
Summary: This study aimed to develop light-color rubber films with minimal protein contamination by incorporating various additives and implementing a leaching procedure. The optimal conditions determined were 0.5% w/w Texapon N70, 0.5% w/w KOH, 1% w/w Uniphen P-23, a 60-min incubation period, and a single leaching cycle with distilled water.
Article
Polymer Science
Setthapong Senarat, Catleya Rojviriya, Katekeaw Sarunyakasitrin, Juree Charoentreeraboon, Wiwat Pichayakorn, Thawatchai Phaechamud
Summary: A drug delivery system based on an aqueous-induced in situ forming gel (ISG) was developed and evaluated for periodontitis treatment. Nitrocellulose (Nc) was used as the polymer, and different solvents were investigated for their effects on physicochemical and bioactivity properties of the ISGs. The Nc-based ISGs exhibited efficient antibacterial activity and prolonged drug release.
Article
Pharmacology & Pharmacy
Chaowalit Monton, Piyapa Keawchay, Chantisa Pokkrong, Pariyakorn Kamnoedthapaya, Abhiruj Navabhatra, Jirapornchai Suksaeree, Thaniya Wunnakup, Natawat Chankana, Thanapat Songsak
Summary: This research optimized the microwave-assisted extraction of Chatuphalathika by varying microwave power, time, and cycle using the Box-Behnken design. The optimal condition yielded the highest extraction yield, total phenolic content, and antioxidant activity. The extracted compound showed good safety profile and was successfully compressed into tablets using specified conditions. This study provides a green extraction method for Chatuphalathika and presents successful formulation of tablets with desirable properties.
SCIENTIA PHARMACEUTICA
(2023)
Article
Pharmacology & Pharmacy
Wiwat Pichayakorn, Pattwat Maneewattanapinyo, Chaowalit Monton, Nattakan Dangmanee, Jirapornchai Suksaeree
Summary: The study demonstrated the use of natural rubber for topical drug delivery and successfully fabricated a porous film loaded with silver nanoparticles. It was discovered that the silver nanoparticles could easily enter the film and exhibited potent antibacterial activity when released.
Article
Biochemistry & Molecular Biology
Pattwat Maneewattanapinyo, Chaowalit Monton, Wiwat Pichayakorn, Jirapornchai Suksaeree
Summary: This study utilized mucilage of C. pareira leaves to manufacture pharmaceutical products. A film was made by combining carrageenan and Eudragit (R) NE30D, with glycerin as a plasticizer. The optimal formulation had a tight and homogeneous film layer, and the drug was quickly released from the film.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Pharmacology & Pharmacy
Chaowalit Monton, Thaniya Wunnakup, Jirapornchai Suksaeree, Laksana Charoenchai, Natawat Chankana
Summary: This study successfully prepared tablets of black pepper extract using the Design of Experiments approach. The optimal tablet formulation consisted of 2.2% CCS, 37% MCC, and a compressional force of 2000 psi, which closely matched the predicted values.
SCIENTIA PHARMACEUTICA
(2023)
