Journal
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
Volume 48, Issue 18, Pages 1987-1993Publisher
WILEY
DOI: 10.1002/polb.22077
Keywords
biological applications of polymers; hydration; poly(ethylene oxide); polyurethanes; protein resistance; solution properties
Categories
Funding
- National Distinguished Young Investigator Fund [20725414]
- Ministry of Science and Technology of China [2007CB936401]
- State Key Lab of Polymer Physics and Chemistry (Changchun)
- Chinese Academy of Sciences
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Polyurethane (PU) containing poly(propylene glycol) (PPG) or poly(tetramethylene oxide) (PTMG) soft segments have been prepared by two-step condensation polymerization. The former (PPG-PU) with a lower critical solution temperature (LCST) at 21 C can change from hydrophilic to hydrophobic, whereas the latter (PTMG-PU) is hydrophobic at a temperature above 0 C. The adsorption of fibrinogen, bovine serum albumin, or lysozyme on such a PU surface in aqueous solution has been investigated by use of quartz crystal microbalance with dissipation (QCM-D) and surface plasmon resonance (SPR) in real time. PPG-PU surface exhibits protein resistance at a temperature below the LCST of PPG, but it significantly adsorbs proteins at a temperature above the LCST. On the other hand, the hydrophobic PTMG-PU surface adsorb the proteins at any temperatures investigated, in contrast with the hydrated poly(ethylene glycol) exhibiting excellent protein resistance. The hydration and dehydration of the polymers at different temperatures were confirmed by Raman spectroscopy. Our study demonstrates that the protein resistance of polymers is determined by their hydration. (C) 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 48: 1987-1993, 2010
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