Article
Polymer Science
Arne Wolpers, Florian Baffie, Vincent Monteil, Franck D'Agosto
Summary: In this study, a dithiocarbamate chain transfer agent was used to synthesize statistical and diblock copolymers of ethylene and vinyl acetate, achieving various polymer compositions through good chain growth control, including linear diblock copolymers and a three-arm star copolymer.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Polymer Science
Zhongyuan Wan, Lee Wai Hin, Ataulla Shegiwal, David Haddleton
Summary: An addition-fragmentation monomer (AFM) is utilized in 3D printer resins to reduce shrinkage during polymerization. The AFM enables reversible network formation and improves mechanical performance. The AFM is synthesized via catalytic chain transfer polymerization (CCTP) and characterized using NMR and size exclusion chromatography (SEC). The incorporation of AFM as a crosslinker allows for rapid reversible covalent bond formation and reduces both polymerization shrinkage and stress buildup.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Joji Tanaka, Noel Edward Archer, Michael Jeffery Grant, Wei You
Summary: In this study, RAFT step-growth polymerization was achieved by combining RAFT and step-growth polymerization mechanisms, resulting in backbone repeat units with a pendant RAFT agent that can form molecular brush polymers in a second polymerization step. The cleavable backbone functionality allows the transformation of brushlike polymers into linear chains of uniform size under stimuli.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Pinar Akarsu, Stefan Reinicke, Anne-Catherine Lehnen, Marek Bekir, Alexander Boeker, Matthias Hartlieb, Martin Reifarth
Summary: The study demonstrates a feasible method to fabricate patchy silicon dioxide microspheres, which can be equipped with tailor-made polymeric materials as patches. The method relies on a solid-state supported microcontact printing (μCP) routine optimized for the transfer of functional groups to capillary-active substrates, introducing amino functionalities as patches to a monolayer of particles. Acting as anchor groups for polymerization, photo-iniferter reversible addition-fragmentation chain-transfer (RAFT) is used to graft polymer from the patch areas. The protocol promises a vast degree of freedom in engineering the surface properties of highly functional patchy particles, making it a platform technology for the fabrication of particles with locally precisely formed patches.
Article
Green & Sustainable Science & Technology
Xiuxian Zhao, Junhua Sun, Jiachen Ma, Tongyao Liu, Zeyi Guo, Zhen Yang, Wei Yao, Xuchuan Jiang
Summary: Vanadium dioxide (VO2) is considered as a promising material for smart windows. However, its real application is hindered by several limitations. In this study, core-shell structured VO2@PMMA-b-PHFBMA nanoparticles with excellent properties were prepared using a RAFT polymerization method. The addition of a F-containing polymer shell improved the stability and compatibility of the VO2 nanoparticles. Furthermore, a photochromic and hydrophobic copolymer was synthesized and coated onto the VO2 nanoparticles to create an energy-saving composite film. The composite film showed high solar modulation efficiency, making it a highly promising application for smart windows.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2022)
Article
Pharmacology & Pharmacy
Christopher N. Subasic, Aditya Ardana, Linda J. Chan, Fei Huang, Judith A. Scoble, Neville J. Butcher, Laurence Meagher, John Chiefari, Lisa M. Kaminskas, Charlotte C. Williams
Summary: This study investigated the potential of RAFT polymers as an alternative to PEG for prolonging the plasma exposure of therapeutic proteins. Among the tested polymers, p(HPMA-co-NIPAM) showed the most promise in prolonging plasma exposure of trastuzumab-Fab' and full length mAb, with lower immunogenicity compared to PEG. These findings suggest that p(HPMA-co-NIPAM) could be a promising copolymer for conjugation with therapeutic proteins.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Polymer Science
Sofia L. Goodrich, Madison E. Ross, James B. Young, Brent S. Sumerlin
Summary: In this study, sonochemically initiated reversible addition-fragmentation chain transfer polymerization was achieved by employing low-frequency ultrasound at high monomer concentrations. Dilution with N,N-dimethylacetamide was found to increase the conversion rate.
Article
Materials Science, Multidisciplinary
Yuma Ueno, Hayato Nakazaki, Hina Onozaki, Shingo Tamesue
Summary: Researchers developed a growable adhesive gel system using RAFT polymerization, which can change its characteristics similar to human growth. The adhesive joint grown by RAFT polymerization showed higher adhesive strength and a function of thermal responsiveness compared to non-RAFT-polymerized adhesive joint. These growable adhesive gel systems enable long-term use of gel materials while adapting to environmental changes.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Polymer Science
Parker T. Boeck, Noel E. Archer, Joji Tanaka, Wei You
Summary: Commercially available N-aromatic substituted bismaleimides were used in RAFT step-growth polymerization with a bifunctional RAFT agent, resulting in polymers with moderate to high molecular weights. This advancement allows for the preparation of graft copolymers in a straightforward manner at a larger scale, increasing the accessibility of the previously reported methodology.
Article
Polymer Science
Iris Lamparth, David Wottawa, Jorg Angermann, Pascal Fassler, Robert Liska, Yohann Catel
Summary: This study investigated the effects of four new urethane-based AFCT agents on dental composites, which can improve mechanical properties and reduce shrinkage force, providing effective technological support for the formulation of low-shrinkage materials.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Polymer Science
Zhiying Li, Qianjin Lian, Youwei Xu, Yichuan Zhang, Pengfei Zhang, Jin Geng
Summary: A robust aggregation-induced emission luminogen photoaddition-fragmentation chain transfer (PET-RAFT) polymerization was investigated, resulting in the preparation of a variety of well-defined polymers with narrow polydispersities (D < 1.20). The use of low concentrations of a donor-acceptor (D-A) type aggregation-induced emission luminogen as a photocatalyst enabled polymerization under visible light at ambient temperature. Previous studies have mainly focused on organic solvents, with fewer investigations conducted in aqueous environments. This study successfully demonstrated the polymerization strategy in water with or without oxygen, leading to the synthesis of structure-controlled polymers. Furthermore, the fluorescence intensity of DCDPP-2TPA increased linearly with the degree of polymerization.
Article
Polymer Science
Mengmeng Zhang, Jiajia Li, Miao Chen, Xiangqiang Pan, Zhengbiao Zhang, Jian Zhu
Summary: The article introduces a new method for controlling the molecular weight distribution of polymers through photocontrol, allowing for the transformation from a latent initiator to an initiator during polymerization. This approach can produce polymers with controlled molecular weight and narrow distributions under mild conditions, demonstrating the potential for tuning MWDs in batch polymerization.
Article
Polymer Science
Zhiying Li, Qianjin Lian, Youwei Xu, Yichuan Zhang, Pengfei Zhang, Jin Geng
Summary: This study investigates the application of a robust aggregation-induced emission luminogen photocatalyst in PET-RAFT polymerization. Well-defined polymers with narrow polydispersities were successfully prepared using this photocatalyst under visible light, and the polymerization process was demonstrated in aqueous environments. Furthermore, the fluorescence intensity linearly increased with the degree of polymerization.
Article
Polymer Science
Benjamin Grob, Benedikt Frieser, Robert Liska, Yohann Catel
Summary: Polymerization shrinkage and shrinkage stress are crucial issues in dental restorations. Addition fragmentation chain transfer agents (AFCT agents) are effective in reducing shrinkage stress. Four novel polymerizable allyl sulfides were synthesized and evaluated in dental composites. AFCT-based composites showed good performance.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Florian Hafliger, Nghia P. Truong, Hyun Suk Wang, Athina Anastasaki
Summary: Thermal RAFT depolymerization is a promising method for chemical recycling of polymers. The fate of the RAFT end-group after depolymerization has been unexplored. This study identifies the dominant small molecules derived from the RAFT end-group of polymethacrylates and shows that the major product is a unimer RAFT agent with high activity for methyl methacrylate.
Article
Multidisciplinary Sciences
Stacey M. Chin, Christopher V. Synatschke, Shuangping Liu, Rikkert J. Nap, Nicholas A. Sather, Qifeng Wang, Zaida Alvarez, Alexandra N. Edelbrock, Timmy Fyrner, Liam C. Palmer, Igal Szleifer, Monica Olvera de la Cruz, Samuel I. Stupp
NATURE COMMUNICATIONS
(2018)
Article
Polymer Science
Stacey M. Chin, Hongkun He, Dominik Konkolewicz, Krzysztof Matyjaszewski
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
(2014)
Article
Chemistry, Multidisciplinary
Alexandra N. Edelbrock, Zaida Alvarez, Dina Simkin, Timmy Fyrner, Stacey M. Chin, Kohei Sato, Evangelos Kiskinis, Samuel I. Stupp
Article
Engineering, Biomedical
Erica B. Peters, Nick D. Tsihlis, Mark R. Karver, Stacey M. Chin, Bruno Musetti, Benjamin T. Ledford, Edward M. Bahnson, Samuel I. Stupp, Melina R. Kibbe
ADVANCED HEALTHCARE MATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Hiroaki Sai, Garrett C. Lau, Adam J. Dannenhoffer, Stacey M. Chin, Luka Dordevic, Samuel Stupp
Article
Chemistry, Physical
Chuang Li, Aysenur Iscen, Hiroaki Sai, Kohei Sato, Nicholas A. Sather, Stacey M. Chin, Zaida Alvarez, Liam C. Palmer, George C. Schatz, Samuel Stupp
Article
Chemistry, Multidisciplinary
Alexandra N. Edelbrock, Tristan D. Clemons, Stacey M. Chin, Joshua J. W. Roan, Eric P. Bruckner, Zaida Alvarez, Jack F. Edelbrock, Kristen S. Wek, Samuel I. Stupp
Summary: The study reports a supramolecular system where interactions between peptide amphiphiles and beta-cyclodextrin with adamantane lead to the formation of a mechanically robust hydrogel with highly porous architecture, which can be 3D printed and exhibits significant bioactivity towards neurons. This nanostructured hydrogel based on supramolecular assembly has potential applications in neuronal research and biomaterial design.
Article
Biochemistry & Molecular Biology
Huihua Xing, Stacey M. Chin, Venkata Reddy Udumula, Maddeboina Krishnaiah, Nathalia Rodrigues de Almeida, Cristian Huck-Iriart, Agustin S. Picco, Sieun Ruth Lee, Gervasio Zaldivar, Kelsey A. Jackson, Mario Tagliazucchi, Samuel Stupp, Martin Conda-Sheridan
Summary: This study demonstrates that the self-assembly behavior of peptide amphiphiles can be effectively tuned by replacing carboxylic acids exposed to aqueous media with isosteres. The nanostructure's morphologies are responsive to the ionization states of the side chains, as indicated by transmission electron microscopy, atomic force microscopy, and small-angle X-ray scattering studies. Theoretical studies show that isosteric replacements allow for pH control of supramolecular morphology by manipulating the pK(a) of charged groups located on the nanostructure's surface.
Article
Chemistry, Multidisciplinary
M. Hussain Sangji, Hiroaki Sai, Stacey M. Chin, Sieun Ruth Lee, Ivan R. Sasselli, Liam C. Palmer, Samuel Stupp
Summary: The morphology of supramolecular peptide nanostructures is influenced by factors such as the balance of molecule packing, the diversity of peptide sequences, and the twisting of beta-sheets. Altering the peptide sequence can change the morphology and supramolecular chirality of the nanostructures. Additionally, increasing charge repulsion between molecules leads to a change in morphology.
Correction
Chemistry, Multidisciplinary
M. Hussain Sangji, Hiroaki Sai, Stacey M. Chin, Sieun Ruth Lee, Ivan R. Sasselli, Liam C. Palmer, Samuel I. Stupp
Article
Multidisciplinary Sciences
Z. Alvarez, A. N. Kolberg-Edelbrock, I. R. Sasselli, J. A. Ortega, R. Qiu, Z. Syrgiannis, P. A. Mirau, F. Chen, S. M. Chin, S. Weigand, E. Kiskinis, S. Stupp
Summary: Researchers have successfully utilized peptide amphiphile supramolecular polymers containing two distinct signals to achieve cell signaling and tissue regeneration in a mouse model of severe spinal cord injury. By mutating the peptide sequence of the monomers, they intensified the motions of molecules within scaffold fibrils, resulting in notable effects such as vascular growth, axonal regeneration, and functional recovery. The study suggests that optimizing cell signaling through ensembles of molecules could be achieved by tuning their internal motions.
Article
Chemistry, Multidisciplinary
Adam Dannenhoffer, Hiroaki Sai, Dongxu Huang, Benjamin Nagasing, Boris Harutyunyan, Daniel J. Fairfield, Taner Aytun, Stacey M. Chin, Michael J. Bedzyk, Monica Olvera de la Cruz, Samuel Stupp
