Review
Pharmacology & Pharmacy
Lorenzo Marsili, Michele Dal Bo, Federico Berti, Giuseppe Toffoli
Summary: Microgels are soft, porous, and deformable particles with an internal gel structure that are swollen by a solvent, making them potential candidates for drug delivery systems. Recent advancements in biodegradable polymer fabrication have led to new strategies in combining synthetic and natural-origin polymers with inorganic nanoparticles for controlled drug release. The use of chitosan-grafted-poly-(N-vinylcaprolactam) microgels in drug delivery and oncology applications is reviewed in this study.
Article
Chemistry, Multidisciplinary
Maylis Garnier, Tugrul Cem Bicak, Michele Sabbah, Nebewia Griffete
Summary: We present a monomer-free approach for the synthesis of fluorescent and stable magnetic nanocomposites using a benzophenone/rhodamine B bimolecular photoinitiator system. This method enables the one-step synthesis of a fluorescent polymer shell layer around magnetic nanoparticles under ambient temperature by UV irradiation.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Anne C. Nickel, Andrey A. Rudov, Igor I. Potemkin, Jerome J. Crassous, Walter Richtering
Summary: This study compares the interfacial deformation and assembly of anisotropic core-shell and hollow microgels and highlights the importance of microgel shape and stiffness on their behavior at the interface.
Article
Chemistry, Physical
Dina M. Silva, Ruy Liu, Anabela F. Goncalves, Andre da Costa, Andreia Castro Gomes, Raul Machado, Jitraporn Vongsvivut, Mark J. Tobin, Vitor Sencadas
Summary: The study successfully produced polymer-polymer core-shell microparticles through emulsion and spray drying, with suitable size for inhalation therapies. These microparticles have the potential to combine and release different drugs effectively, offering promising clinical applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Jacopo Vialetto, Fabrizio Camerin, Shivaprakash N. Ramakrishna, Emanuela Zaccarelli, Lucio Isa
Summary: The encapsulation of a rigid core within a soft polymeric shell allows obtaining composite colloidal particles with retained functional properties. The authors investigated the interfacial morphology of these particles and identified that the core properties, shell thicknesses, and grafting density can influence their conformation. By understanding their wetting behavior, these composite particles can be designed to exhibit specific inter-particle interactions for the stabilization of interfaces and the fabrication of tailored 2D materials with functional properties.
Review
Chemistry, Multidisciplinary
Wojciech Drozdz, Artur Ciesielski, Artur R. Stefankiewicz
Summary: Interest in capsular assemblies, such as dynamic organic and coordination cages, has grown significantly over the past decade. These systems have found applications in various research fields and are increasingly being used in the formation of complex systems and smart materials. This Review discusses promising pathways to overcome common drawbacks of cage systems and strategies for their hybridization with systems of different dimensionalities. The structure-dependent relationship between the employed cages and the properties of the materials is also highlighted.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Murtaza Haider Syed, Md Maksudur Rahman Khan, Mior Ahmad Khushairi Mohd Zahari, Mohammad Dalour Hossen Beg, Norhayati Abdullah
Summary: Electrospinning is an advanced method to produce nanofibers using polymers, and its application has shifted toward biopolymers. This review focuses on the ignored parameters and new innovative methods in current research, aiming to improve the properties of nanofiber biocomposites. The findings highlight the significance of electrospinning for biomedical applications compared to conventional methods.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Polymer Science
Badr M. Thamer, Ali Aldalbahi, Meera A. Moydeen, Mostafizur Rahaman, Mohamed H. El-Newehy
Summary: Electrospun polymer nanofibers are effective adsorbents for the removal of water pollutants, especially for dye removal, due to their high efficiency, stability, and reusability. Surface modification can further enhance their adsorption efficiency and stability in aqueous media.
Article
Chemistry, Physical
Andrea Scotti, Urs Gasser, Alexander Petrunin, Lisa Fruhner, Walter Richtering, Judith E. Houston
Summary: This study used small-angle neutron scattering to investigate the bulk modulus of polymeric nanocapsules and found that the size of the cavity is the most important factor determining the softness of the nanocapsules.
Article
Materials Science, Multidisciplinary
Qian Wang, Luqing Cao, Yuyin Wang, Mingqi Qin, Qianqian Wang
Summary: The ZnO/Fe2O3 nanocomposite prepared by direct precipitation method exhibits both UV and blue light protection advantages. The material is suitable for use in sunscreen products and has a natural reddish hue.
Article
Chemistry, Multidisciplinary
Rizwan Ahmed, Mingwei Wang, Zhiyao Qi, Noor ul Ain Hira, Jiahui Jiang, Hongsen Zhang, Shahid Iqbal, Junyou Wang, Martien Abraham Cohen Stuart, Xuhong Guo
Summary: Chitosan nanoparticles prepared through pH control showed stable Pickering emulsions without the need for further chemical modifications or extra additives. These emulsions were stable for 45 days, exhibited strong antibacterial effects, and did not require additional components for emulsification.
Review
Chemistry, Multidisciplinary
Nabira Fatima, Umair Yaqub Qazi, Asim Mansha, Ijaz Ahmad Bhatti, Rahat Javaid, Qamar Abbas, Nimra Nadeem, Zulfiqar Ahmad Rehan, Saima Noreen, Muhammad Zahid
Summary: Graphene-based polymeric composites exhibit excellent antimicrobial properties through physical and chemical damages, with applications in wound bandages, antimicrobial coatings, drug delivery, food packaging, hydrogel formation, and water disinfection. This review provides valuable insights and may stimulate further developments in the promising field of graphene-based materials.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xin Guan, Yang Liu, Zhili Wan, Ying-Lung Steve Tse, To Ngai
Summary: This study demonstrates a method to control the formation of microgel-laden interfacial layers by introducing octanol into poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-MAA) microgels. The resulting octanol-swollen microgels can diffuse onto water droplet surfaces, leading to the formation of stable inverse water-in-oil Pickering emulsions. These emulsions can be used as templates to create microgel colloidosomes with adjustable shell structures. The microgelsomes have the ability to encapsulate and release various substances and can respond to external stimuli.
Article
Chemistry, Physical
Nicolo Mauro, Gaetano Giammona, Elisabetta Ranucci, Paolo Ferruti
Summary: Polyamidoamines (PAAs) are biocompatible, biodegradable polymers that have great potential for pharmaceutical applications. A statistical approach was developed to fine-tune the aza-Michael polyaddition stoichiometry for obtaining microgels or hyperbranched polymers in a one-pot reaction. The synthesized biocompatible microgels have tunable size distribution and well-designed end-chains, showing great potential for medical applications.
Review
Polymer Science
Fabrice Ofridam, Mohamad Tarhini, Noureddine Lebaz, Emilie Gagniere, Denis Mangin, Abdelhamid Elaissari
Summary: Stimuli-responsive materials, specifically pH-responsive polymers, have attracted increasing interest due to their ability to undergo sharp and reversible changes in response to environmental pH conditions, leading to a wide range of applications in various fields.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Polymer Science
Betul Ari, Mehtap Sahiner, Sahin Demirci, Nurettin Sahiner
Summary: The combination of PVA with TA and Cur in cryogel composites showed high antioxidant and antibacterial activities, with potential for blood contacting applications. Release of TA and Cur from the composites was quantified at different pH conditions, showing concentration-dependent enzyme inhibition against alpha-glucosidase.
Article
Chemistry, Analytical
Selin S. Suner, Sahin Demirci, Duygu S. Sutekin, Selehattin Yilmaz, Nurettin Sahiner
Summary: A new thiourea hexamethylene diisocyanate covalent organic framework (TH COF) with adjustable surface charge and area was successfully synthesized, exhibiting excellent acid-base absorption capability and reusability.
Review
Biochemistry & Molecular Biology
Mehtap Sahiner, A. Sanem Yilmaz, Buket Gungor, Yasmin Ayoubi, Nurettin Sahiner
Summary: The prevalence of cardiovascular disease, oxidative stress-related complications, and chronic age-related illnesses is increasing worldwide. Traditional medicinal treatments often have limitations, such as ineffectiveness, toxicity, and the need for multiple drugs in certain chronic diseases. Therefore, alternative treatment methods are necessary. Polyphenolic compounds have been shown to possess cardioprotective, ROS scavenging, anti-aging, and anticancer properties, and they have the potential to be used as alternative therapeutic agents.
Article
Polymer Science
Mehtap Sahiner, Selin S. Suner, Aynur S. Yilmaz, Nurettin Sahiner
Summary: Polyelectrolyte microgels derived from chondroitin sulfate (CS) are promising therapeutic carriers for long-term drug delivery applications. In this study, chemically crosslinked CS microgels were synthesized and then transformed into polyelectrolyte CS-[NH4](+) microgels through a cation exchange reaction. These microgels exhibited injectability, controllable degradation capability, and enhanced drug loading capacity compared to CS microgels. The loaded drug was sustainably released for a long-term period, and the RA-loaded CS-[R](+) microgels showed excellent antioxidant activity.
Article
Oncology
Ertug Avci, Hulya Yilmaz, Nurettin Sahiner, Bilge Guvenc Tuna, Munevver Burcu Cicekdal, Mehmet Eser, Kayhan Basak, Fatih Altintoprak, Ismail Zengin, Soner Dogan, Mustafa Culha
Summary: This study investigates the reliability of surface-enhanced Raman scattering (SERS) for cancer diagnosis by varying several parameters. The results demonstrate the potential of this technique to accurately differentiate blood samples from cancer patients, healthy individuals, and patients with chronic diseases.
Article
Materials Science, Composites
Mehtap Sahiner, Betul Ari, Manoj K. Ram, Nurettin Sahiner
Summary: In this study, nitrogen-doped carbon dots (N-doped CDs) with fluorescence and antimicrobial properties were synthesized by the hydrothermal method and embedded within poly(lactic acid-co-glycolic acid) (PLGA) films. The results showed that the fluorescence intensity increased with the amount of CDs in CD@PLGA films. The 50-CD@PLGA films exhibited antimicrobial activity against S. aureus and E. coli microorganisms. Furthermore, the 50-CD@PLGA film released about 38% of the embedded CDs in approximately 12 days and demonstrated good blood compatibility.
JOURNAL OF COMPOSITES SCIENCE
(2022)
Article
Chemistry, Physical
Selin S. Suner, Mehtap Sahiner, Aynur S. Yilmaz, Ramesh S. Ayyala, Nurettin Sahiner
Summary: Nitrogen-doped arginine carbon dots were prepared as light-sensitive antibacterial agents using a microwave-assisted synthesis method. The modified Arg CDs showed enhanced antibacterial effects, with PEI-modified Arg CDs exhibiting the highest antibacterial capability. Photodynamic antibacterial tests revealed that EDA-modified Arg CDs had a significant inhibitory effect on pathogenic bacteria under light exposure.
Article
Pharmacology & Pharmacy
Mehtap Sahiner, Aynur S. S. Yilmaz, Ramesh S. S. Ayyala, Nurettin Sahiner
Summary: Poly(glycerol) (p(Gly)) particles were successfully synthesized using the micro-emulsion method, with an average size of 14.5+/-5.6 μm. The particles showed good biocompatibility and non-toxicity, making them promising vehicles for drug delivery systems. Loading the flavonoid quercetin into the p(Gly) particles demonstrated their improved bioavailability and sustained release profiles.
Review
Engineering, Biomedical
Mehtap Sahiner, Aynur Sanem Yilmaz, Buket Gungor, Nurettin Sahiner
Summary: Neurodegenerative diseases are characterized by the progressive loss and death of nerve cells, and efforts are being made to understand their pathogenesis. This review focuses on Alzheimer's disease, which has a high prevalence and lacks radical treatment, and explores the potential neurological effects of phytochemicals as therapeutic agents. The survey highlights the inhibitory effects of herbal compounds on acetylcholinesterase, an enzyme with significant value in AD treatment. It has been shown that phytopharmaceuticals can have long-term effects in protecting nervous system health, reducing inflammation, improving cognitive damage, and alleviating dementia sequelae. Herbal-based therapeutics offer advantages as new generation or complementary agents with high compliance, fewer adverse effects, and lower cost compared to traditional pharmaceutical agents in the fight against AD.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Polymer Science
Cihan Aktas, Osman Polat, Mohamadreza Beitollahpoor, Melika Farzam, Noshir S. Pesika, Nurettin Sahiner
Summary: In this study, the effect of plasma treatment on the wetting properties of LDPE films was investigated. The contact angle and surface energy values of LDPE films changed after plasma treatment. Kinetic friction force measurements proved to be more sensitive than contact angle measurements in differentiating the wetting properties of different LDPE films.
Article
Chemistry, Medicinal
Selin S. Suner, Mehtap Sahiner, Evrim Umut, Ramesh S. Ayyala, Nurettin Sahiner
Summary: Chondroitin sulfate (CS) was physically crosslinked with Fe(III), Gd(III), Zn(II), and Cu(II) ions to obtain CS-metal ion-containing particles. These particles have the potential for use as injectable materials for intravenous administration, with excellent blood compatibility and low cytotoxicity. Additionally, CS-Zn(II) and CS-Cu(II) particles show strong antibacterial activity, and the CS-metal ion particles can enhance contrast in magnetic resonance imaging (MRI), making them versatile biomaterials.
Article
Polymer Science
Mehtap Sahiner, Aynur S. Yilmaz, Ramesh S. Ayyala, Nurettin Sahiner
Summary: In this study, water-soluble microgels of glycol chitosan (GC) were synthesized and their blood and cell compatibility were tested. The results showed that the microgels exhibited good blood compatibility and cell viability. Furthermore, the microgels were used for drug delivery of tannic acid (TA), and they exhibited strong antioxidant activity.
Article
Chemistry, Physical
Selin S. Suner, Venkat R. Bhethanabotla, Ramesh S. Ayyala, Nurettin Sahiner
Summary: Photo-activated antipathogenic carbon dots were prepared by modifying arginine carbon dots with fluorescent dyes, leading to enhanced antimicrobial potency. These modified carbon dots showed excellent fluorescence properties and broad-spectrum antimicrobial activity, with the photosensitive arginine-riboflavin carbon dots exhibiting the strongest antibacterial effect.
Article
Polymer Science
Mehtap Sahiner, Aynur S. Yilmaz, Ramesh S. Ayyala, Nurettin Sahiner
Summary: Carboxymethyl chitosan microgels show excellent biocompatibility and drug-loading ability, making them important in antibacterial applications. These microgels, synthesized in a microemulsion environment, have tailored size and zeta potential values, and possess a spherical structure.
Article
Polymer Science
Sahin Demirci, Mehtap Sahiner, Betul Ari, Aydin K. Sunol, Nurettin Sahiner
Summary: Cryogels derived from natural materials have excellent properties for biomedical applications, with CS and CS:HNT cryogels showing mild blood clotting capabilities and adjustable swelling properties. Alphaglucosidase enzyme interactions were also found to be stimulated by CS-based cryogels.