Article
Chemistry, Multidisciplinary
Jincai Li, Joseph J. Richardson, Hirotaka Ejima
Summary: This article reports the first synthesis of dithiocatechol-pendant polymers using a novel protection-deprotection strategy. The resulting polymers are soluble in common organic solvents and can be fully characterized by standard spectroscopic methods. The study also demonstrates the possibility of using reversible addition-fragmentation chain-transfer polymerization to synthesize dithiocatechol-pendant polymers.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Qingyun Li, Ziqing Hu, Xiaofan Ji
Summary: The click reaction, with its characteristics of high efficiency, atom economy, and simple reaction conditions, has been widely applied in various fields. However, it was previously unable to connect macroscopic building blocks. In this work, macroscopic click chemistry was achieved using hydrogels as macroscopic building blocks. This approach allows for flexible manufacturing of three-dimensional structures at the macroscopic level, opening up new possibilities for delicate design and large-scale production.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Shuheng Xu, Sunliang Cui
Summary: The sulfonyl fluoro isocyanides were developed as a new type of SuFExable synthon and utilized as building blocks in the Ugi reaction. This study established the Ugi reaction and explored its substrate scope, allowing for the one-step synthesis of various sulfonyl fluoro alpha-amino amides and peptides. This protocol presents a novel approach for SuFExable building blocks and click chemistry, as well as offering a distinct method for sulfonyl fluoro peptides.
Article
Chemistry, Multidisciplinary
Pierre Tournier, Garance Saint-Pe, Nathan Lagneau, Francois Loll, Boris Halgand, Arnaud Tessier, Jerome Guicheux, Catherine Le Visage, Vianney Delplace
Summary: This study introduces a new biomaterial concept, clickable dynamic bioinks. These bioinks use dynamic hydrogels that can be 3D-bioprinted and chemically modified via click and bioorthogonal reactions to allow a variety of post-printing modifications. These modifications include adjusting the bioink composition and stiffness, as well as promoting cell adhesion, and can be controlled over time and space for 4D bioprinting applications.
Article
Chemistry, Applied
Fengling Liu, Lu Wang, Xinrang Zhai, Shunxian Ji, Jingjia Ye, Zhiqiang Zhu, Chong Teng, Wei Dong, Wei Wei
Summary: In this study, a multi-functional chitosan hydrogel was designed by combining chitosan methacrylate and sulfhydrated chitosan and cross-linking them through two reactions. The resulting hydrogel exhibited superior tissue adhesive properties, mechanical properties, and antimicrobial effects. Furthermore, it showed good biocompatibility and promoted skin repair in both cell experiments and animal experiments.
CARBOHYDRATE POLYMERS
(2023)
Article
Nanoscience & Nanotechnology
Robin Wanka, Florian Koschitzki, Vuk Puzovic, Thorben Pahl, Emily Manderfeld, Kelli Z. Hunsucker, Geoffrey W. Swain, Axel Rosenhahn
Summary: A new dendritic PG-HEMA material was synthesized chemically and compared with commercially available hydrophilic monomers, showing that PPGMA exhibited better resistance to silt incorporation and outperformed PEGMA and PG(4)MA in the DSFE assay.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Mario Saletti, Marco Paolino, Lavinia Ballerini, Germano Giuliani, Gemma Leone, Stefania Lamponi, Marco Andreassi, Claudia Bonechi, Alessandro Donati, Daniele Piovani, Alberto Giacometti Schieroni, Agnese Magnani, Andrea Cappelli
Summary: An easy and viable crosslinking procedure using click-chemistry was developed for hyaluronic acid. The resulting crosslinked materials showed no cytotoxic effects, tunable water affinity, and rheological properties, suggesting potential applications in different biomedical fields.
Article
Chemistry, Multidisciplinary
Yuuya Kawasaki, Tomoya Hayashibara, Yuki Seto, Yutaro Taniguchi, Kazunobu Igawa, Katsuhiko Tomooka
Summary: DACN-NHS ester and DACN-maleimide are molecular connectors used for the synthesis of artificial hybrid biomolecules. The synthesis process involves two steps: connection to a corresponding molecule via the NHS ester or maleimide unit, followed by connection to a corresponding azido-containing molecule via DACN unit through copper-free-alkyne-azide-cycloaddition. The developed DACN derivatives, DACN-NHS ester and DACN-maleimide, have shown the ability to hybridize biomolecules.
CHEMICAL COMMUNICATIONS
(2023)
Article
Polymer Science
Andres Otalora, Tulio A. Lerma, Manuel Palencia
Summary: This study proposes and evaluates a novel one-pot synthesis method for polymeric hydrogels (HGs) based on isocyanate click chemistry. The results show that the proposed method allows for the synthesis of HGs with different carbonyl groups, which can impact and modulate the structural, thermal, and functional behavior of the HGs. The study also demonstrates the advantages of the HGs in terms of thermal stability, glass transition temperature, water absorption capacity, and antibacterial properties.
JOURNAL OF POLYMER RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Alex Mapp, Jamie T. Wilmore, Paul D. Beer, Jose M. Goicoechea
Summary: Described the synthesis of a new class of inorganic rotaxanes containing gold(I) triazaphosphole stoppers using the cyaphide-azide 1,3-dipolar cycloaddition reaction. Bis-azides reacted with Au(IDipp)(CP) in aromatic solvents to produce interlocked molecules via an inorganic click reaction. The resulting organometallic rotaxanes were air- and moisture-stable and could be purified under aerobic conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
N. R. Richbourg, M. Wancura, A. E. Gilchrist, S. Toubbeh, B. A. C. Harley, E. Cosgriff-Hernandez, N. A. Peppas
Summary: This study investigates how changes in synthesis conditions affect the network structure of hydrogels, and identifies linear correlations between synthesis variables and swelling behavior. It also demonstrates that complex biopolymer structures can disrupt the linear synthesis-swelling correlations. These findings provide insight into controlling hydrogel physical properties through structural design and can be used to optimize biomedically relevant hydrogels.
Article
Polymer Science
Md Murshed Bhuyan, Jae-Ho Jeong
Summary: The gamma radiation technique is used to prepare pure hydrogels, which are essential in various fields. This study focuses on the preparation and characterization of DMAA-AMPSA superabsorbent hydrogel using gamma radiation and determining the optimal dose. The equilibrium swelling increases with increasing radiation dose, reaching a maximum of 26,324.9% at 10 kGy. The characterization techniques confirm the formation of the co-polymer and the thermal stability of the gel.
Article
Biophysics
Changkyu Lee
Summary: In this study, a GOD-gelatin hydrogel was prepared and demonstrated its potential in suppressing tumor recurrence after breast cancer surgery. It showed anticancer effects through H2O2 generation and remained at the surgical site to continuously suppress tumor recurrence.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Polymer Science
Daniel M. Gruber, Mark S. Ferris, Gary Zabow
Summary: Here, a new method is presented for accurate in-situ monitoring of hydrogel swelling in real-time using single-sided nuclear magnetic resonance (NMR) profiling. The method reduces experimenter bias and uncertainty intrinsic to common weighing and caliper methods. NMR profiling additionally provides dynamic swelling rates over time, without needing to touch or modify the sample.
Article
Chemistry, Multidisciplinary
Christopher J. Smedley, Joshua A. Homer, Timothy L. Gialelis, Andrew S. Barrow, Rebecca A. Koelln, John E. Moses
Summary: Accelerated SuFEx click chemistry (ASCC) is an improved method for efficient and catalytic coupling of aryl and alkyl alcohols with various SuFExable hubs. The powerful combination of BTMG and HMDS reagents allows for lower catalyst loadings, providing a scalable method that is safe, efficient, and practical for modular synthesis. ASSC expands the accessibility of SuFEx products and will have significant applications in organic synthesis, medicinal chemistry, chemical biology, and materials science.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)