Article
Chemistry, Organic
Yulia Krivolapova, Olesya A. Tomashenko, Liya D. Funt, Dar'ya Spiridonova, Mikhail S. Novikov, Alexander F. Khlebnikov
Summary: Azirine-triazole hybrids were selectively synthesized under different reaction conditions and the reaction mechanism and selectivity were discussed based on DFT calculations.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Organic
Mohammad Sadegh Asgari, Saeed Bahadorikhalili, Aram Ghaempanah, Parviz Rashidi Ranjbar, Rahmatollah Rahimi, Alireza Abbasi, Bagher Larijani, Mohammad Mahdavi
Summary: In this study, novel amide linked 1,2,3-triazoles containing aryloxy derivatives were synthesized efficiently via copper-catalyzed one-pot sequential reaction, with high isolated yields.
TETRAHEDRON LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Francesca Begini, Renata A. Balaguez, Allya Larroza, Eric F. Lopes, Eder Joao Lenardao, Claudio Santi, Diego Alves
Summary: This study presents a simple method to synthesize 4-arylselanyl-1H-1,2,3-triazoles from selenium-containing carbinols in a one-pot strategy, with moderate to good yields including quinoline and Zidovudine derivatives. One-pot protocols are essential for addressing concerns about waste production and solvent consumption, while also producing interesting by-products with alkynylselenium moieties connected to the triazole.
Article
Chemistry, Inorganic & Nuclear
Nasrin Moeini-Eghbali, Hossein Eshghi
Summary: In this study, a new and selective nanocatalyst (Fe3O4@S-TiO2/Cu) was synthesized by incorporating sulfur heteroatoms onto Fe3O4@TiO2 substrate as a ligand to stabilize copper nanoparticles. The Fe3O4@S-TiO2/Cu nanorods were characterized using various techniques and showed high catalytic activity in preparing triazole derivatives. The nanocatalyst exhibited advantages such as high regioselectivity, short reaction times, easy separation, and recyclability.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Zi-Qi Geng, Chunhui Zhao, Hao-Dong Qian, Si-Jia Li, Hao Peng, Hao Xu
Summary: A Cu/Ag relay catalyzed cascade reaction was used to synthesize chiral triazole-fused pyrazine scaffolds. This method utilized a novel N,N,P-ligand and showed high efficiency, functional group tolerance, excellent enantioselectivities, and a broad substrate scope using readily available starting materials.
Article
Chemistry, Multidisciplinary
Yury N. Kotovshchikov, Stepan S. Tatevosyan, Gennadij V. Latyshev, Zoya R. Kugusheva, Nikolay V. Lukashev, Irina P. Beletskaya
Summary: Universal divergent approaches for the synthesis of 1,2,3-triazole-fused quinazolinones and benzoxazine imines have been developed. These methods utilize the intramolecular base-mediated cyclization of readily available 2-(5-iodotriazolyl)benzamides. The O-attack proceeds through an ambident carboxamide anion, while the N-attack involves Cu-catalyzed Ullmann coupling. These protocols are operationally simple, cost-efficient, and provide a broader scope and better functional group compatibility compared to previous approaches.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Fan Yu, Zhaoman Zhou, Jiajia Song, Yanying Zhao
Summary: This study rationalized the mechanism of Cu(I)-catalyzed 5-enamine-functionalized fully substituted 1,2,3-triazole synthesis using density functional theory (DFT) and multicomponent artificial force-induced reaction (MC-AFIR) methods. The research provided important mechanistic insights for the interrupted CuAAC reaction and identified the rate-determining step as the transmetalation process along the triplet state potential energy surface. Further predictions suggest the role of solvent and extra strong ligand coordination in competitive reactions.
Article
Chemistry, Medicinal
Nayera W. Hassan, Ahmed Sabt, Maryam A. Z. El-Attar, Mikko Ora, Alaa El-Din A. Bekhit, Kikuko Amagase, Adnan A. Bekhit, Ahmed S. F. Belal, Perihan A. Elzahhar
Summary: According to WHO statistics, leishmaniasis is a neglected tropical disease that affects 700,000 to 1 million people annually. Researchers have designed and synthesized a new series of coumarin-1,2,3-triazole hybrid compounds that exhibit higher activity against L. major parasites than miltefosine. These compounds showed strong anti-leishmanial effects, with three of them demonstrating submicromolar potencies. Mechanistic studies revealed that folic and folinic acids reduced the anti-leishmanial effects of these compounds. Docking simulation studies supported the observed biological activities and highlighted the selectivity of these compounds.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Physical
Antonio De Nino, Loredana Maiuolo, Paola Costanzo, Vincenzo Algieri, Antonio Jiritano, Fabrizio Olivito, Matteo Antonio Tallarida
Summary: This review summarizes the progress achieved in the synthesis of 1,2,3-triazoles from 2015 to today, focusing particularly on the development of new catalytic and eco-compatible approaches. The report is subdivided based on the degree of functionalization of the molecules, with emphasis on the role of the catalyst employed for each specific approach.
Article
Chemistry, Organic
Yolanda Navarro, Jesus Garcia Lopez, Maria Jose Iglesias, Fernando Lopez Ortiz
Summary: Through a ligand-free domino copper(I)-catalyzed azide-alkyne-azide process, 1,4-(disubstituted)-5-triazenyl-1,2,3-triazoles were synthesized successfully, and the crucial role of Cu-chelation in the interception of the intermediate by the azide was revealed through DFT calculations and X-ray diffraction analysis.
Article
Chemistry, Multidisciplinary
Linwei Zeng, Jiaming Li, Sunliang Cui
Summary: In this study, we report a rhodium-catalyzed enantioselective click cycloaddition of azides and alkynes, which allows for the rapid and modular synthesis of atropisomeric triazoles with excellent yields and enantioselectivities. The process is mild, efficient, scalable, and has a broad substrate scope.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Alexander N. Koronatov, Kseniia K. Afanaseva, Pavel A. Sakharov, Nikolai V. Rostovskii, Alexander F. Khlebnikov, Mikhail S. Novikov
Summary: A new method for the synthesis of 1-alkyl-3-sulfonamido-1H-pyrroles via the Rh(ii)-catalyzed denitrogenative coupling of two different types of 1,2,3-triazoles has been developed. The reaction mechanism involves the attack of the rhodium-bound azavinyl carbene, leading to the formation of metal-free ylides and subsequent conversion to the desired products. This protocol provides high yields of 3-sulfonamidopyrroles, demonstrating promising synthetic applications.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Applied
Raju Jannapu Reddy, Md Waheed, Arram Haritha Kumari, Gamidi Rama Krishna
Summary: A copper(I)-catalyzed interrupted click-sulfenylation reaction has been developed for the synthesis of triazole-fused eight-membered heterocycles from O-/N-propargyl benzyl thiosulfonates and organic azides. The method provides good to high yields of the products under mild reaction conditions and can also achieve a three-component reaction for fused-triazole synthesis. The protocol has been demonstrated at gram-scale reactions and a plausible mechanism has been proposed based on experimental results.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Organic
Jose Laxio Arenas, Pascal Retailleau, Jean-Michel Gillet, Nour-Eddine Ghermani, Sandrine Ongeri, Benoit Crousse
Summary: The 5-fluoro triazole amino acid scaffold prepared by halogen exchange was successfully incorporated into peptides. The X-ray diffraction results revealed an important localization of the 5-fluoro triazole motif on one side of the negative potential surface, with the fluorine atom showing a cylindrical shape in its electron density deformation.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sampath Kumar Kancharla, Saritha Birudaraju, Arani Pal, L. Krishnakanth Reddy, Eda Rami Reddy, Siva Krishna Vagolu, Dharmarajan Sriram, Kishore Babu Bonige, Raghu Babu Korupolu
Summary: A series of novel isatin oxime ether-tethered aryl 1H-1,2,3-triazole hybrids were designed and synthesized using Cu(I) catalyzed azide-alkyne [3+2] cycloaddition. These compounds showed good in vitro antitubercular activity and low cytotoxicity profiles. The drug-likeness profile of certain compounds indicated their potential as drug candidates.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Materials Science, Ceramics
L. P. Curecheriu, C. E. Ciomaga, V. Musteata, G. Canu, V. Buscaglia, L. Mitoseriu
CERAMICS INTERNATIONAL
(2016)
Article
Chemistry, Multidisciplinary
H. Yu, X. Qiu, A. R. Behzad, V. Musteata, D. -M. Smilgies, S. P. Nunes, K. -V. Peinemann
CHEMICAL COMMUNICATIONS
(2016)
Article
Polymer Science
Sergei Bronnikov, Sergei Kostromin, Valentina Musteata, Vasile Cozan
JOURNAL OF POLYMER RESEARCH
(2016)
Article
Materials Science, Multidisciplinary
Luminita Ioana Buruiana, Ecaterina Avram, Valentina Elena Musteata, Anca Filimon
MATERIALS CHEMISTRY AND PHYSICS
(2016)
Article
Polymer Science
V. Gaina, O. Ursache, C. Gaina, D. Timpu, F. Tanasa
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING
(2016)
Article
Polymer Science
O. Ursache, C. Gaina, V. Gaina
EXPRESS POLYMER LETTERS
(2017)
Article
Engineering, Chemical
Stefan Chisca, Gheorghe Falca, Valentina Elena Musteata, Cristiana Boi, Suzana P. Nunes
JOURNAL OF MEMBRANE SCIENCE
(2017)
Article
Chemistry, Multidisciplinary
Phuoc H. H. Duong, Pei-Ying Hong, Valentina Musteata, Klaus Viktor Peinemann, Suzana P. Nunes
Article
Polymer Science
Valentina Musteata, Burhannudin Sutisna, Georgios Polymeropoulos, Apostolos Avgeropoulos, Florian Meneau, Klaus-Viktor Peinemann, Nikos Hadjichristidis, Suzana P. Nunes
EUROPEAN POLYMER JOURNAL
(2018)
Article
Nanoscience & Nanotechnology
Gheorghe Falca, Valentina E. Musteata, Stefan Chisca, Mohamed Nejib Hedhili, Chisiang Ong, Suzana P. Nunes
Summary: Membrane nanofiltration technology is widely used in pharmaceutical, chemical, and food industries for separating valuable products and recovering solvents. There is a need for greener membrane fabrication methods to ensure environmental friendliness and reduce emissions of volatile solvents during production. Researchers are proposing the use of environmentally friendly solvents and methods to improve membrane preparation processes.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Fatimah Algarni, Valentina Elena Musteata, Gheorghe Falca, Stefan Chisca, Nikos Hadjichristidis, Suzana P. Nunes
Summary: This study reported the synthesis and fabrication of thermo-responsive membranes using PNIPAM-b-PVDF copolymers with linear and star structures. The membranes exhibited reversible thermo-responsive behavior with water permeability and rejection alternately varying with the operating temperature. Nanoporous membranes with zig-zag morphology were successfully fabricated by non-solvent-induced phase-separation method.
Article
Materials Science, Multidisciplinary
Rebecca Esposito, Valentina Musteata, Stefan Chisca, Suzana P. Nunes
Summary: Adhesion between fillers and polymeric matrices is crucial for mixed-matrix membranes in molecular separation, with solution rheology proving to be an effective tool for identifying polymer-filler pairs with strong interaction. The study demonstrated that ZIF-8 and PTA-OH exhibit good adhesion, while PTA and ZIF-8 composites resulted in poor matrix-filler adhesion and undesired cavities.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Multidisciplinary Sciences
Stefan Chisca, Valentina-Elena Musteata, Wen Zhang, Serhii Vasylevskyi, Gheorghe Falca, Edy Abou-Hamad, Abdul-Hamid Emwas, Mustafa Altunkaya, Suzana P. Nunes
Summary: This study presents a versatile strategy for fabricating polytriazole membranes with subnanometer channels and 10-nanometer-thin selective layers, which can be tuned for different applications. These membranes exhibit excellent selectivity and are capable of efficiently separating low-carbon hydrocarbon components.
Article
Multidisciplinary Sciences
Siyao Li, Ruijiao Dong, Valentina-Elena Musteata, Jihoon Kim, Neel D. Rangnekar, J. R. Johnson, Bennett D. Marshall, Stefan Chisca, Jia Xu, Scott Hoy, Benjamin A. McCool, Suzana P. Nunes, Zhiwei Jiang, Andrew G. Livingston
Summary: Hydrophobic polyamide nanofilms can transport hydrophobic liquids faster than conventional membranes and exhibit higher permeance in light crude oil fractionation.
Article
Polymer Science
Constantin Gaina, Oana Ursache, Viorica Gaina
POLYMER-PLASTICS TECHNOLOGY AND MATERIALS
(2019)
