Article
Immunology
H. E. Burzynski, K. E. Ayala, M. A. Frick, H. A. Dufala, J. L. Woodruff, V. A. Macht, B. R. Eberl, F. Hollis, J. A. McQuail, C. A. Grillo, J. R. Fadel, L. P. Reagan
Summary: Gulf War Illness (GWI) refers to the multiple disturbances in the central and peripheral systems of soldiers who served in the 1990-1991 Gulf War. The use of the reversible acetylcholinesterase inhibitor, pyridostigmine bromide (PB), and war-related stress have been identified as key factors in GWI pathology. A study found that PB-treated rats exhibited impaired hippocampal cholinergic responses to an immobilization stress challenge three months after PB administration. In addition, these rats showed 24-hour memory deficits in hippocampal-dependent learning and memory tasks when challenged with lipopolysaccharide (LPS) at the same delayed timepoint.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Soil Science
Iviwe Notununu, Lucy Moleleki, Ashira Roopnarain, Rasheed Adeleke
Summary: Drought and heat are common environmental stresses that negatively affect maize growth and productivity. The use of plant growth-promoting rhizobacteria (PGPR) is a promising strategy to enhance drought and heat stress tolerance in maize by influencing molecular, metabolic, and physiological stress responses. This review provides an assessment of current knowledge on the ability of PGPR to induce drought and heat stress tolerance in maize plants.
Article
Plant Sciences
Qianqian Qin, Yujun Zhao, Jiajun Zhang, Li Chen, Weina Si, Haiyang Jiang
Summary: In this study, an HSF gene ZmHsf11 was cloned from maize and found to negatively regulate the expression of oxidative stress-related genes, increase ROS levels, and decrease proline content, thereby reducing plant tolerance to heat stress.
Article
Plant Sciences
Zhaoxia Li, Juren Zhang
Summary: This article discusses the impact of heat stress on maize production in China and the response mechanisms of maize plants to high temperatures. The study reveals that cells regulate their activities in various ways to adapt to the stress of unfavorable environments under high temperature conditions. In addition, the article also discusses the perception of heat stress and the systemically acquired acclimation in maize, as well as the challenges and prospects of improving maize thermotolerance through breeding and genetic manipulation.
Article
Multidisciplinary Sciences
Junfei Xia, Hongrong Yang, Michelle Mu, Nicholas Micovic, Kira E. Poskanzer, James R. Monaghan, Heather A. Clark
Summary: The DNA-based enzymatic nanosensor presented allows for quantitative detection of acetylcholine (ACh) in living mice, demonstrating sensitivity, dose-dependent response, reversibility, and pharmacological inhibition effects. The platform also enables spatial resolution of ACh signal propagation at the tissue level in the peripheral nervous system.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Junfei Xia, Hongrong Yang, Michelle Mu, Nicholas Micovic, Kira E. Poskanzer, James R. Monaghan, Heather A. Clark
Summary: This study presents a DNA-based enzymatic nanosensor for quantitative detection of acetylcholine in the peripheral nervous system of living mice. The nanosensors are demonstrated to sensitively detect ACh levels, show dose-dependent and reversible responses to electrical stimulation, and exhibit a reduction in signal upon pharmacological inhibition. Additionally, an advanced imaging processing tool enables spatially resolving ACh signal propagation on the tissue level.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Forestry
Zidan Cao, Enbo Wang, Xinyi Xu, Chenheng Tong, Xia Zhao, Xiqiang Song, Jian Wang, Hou-ling Wang, Xinli Xia, Ying Zhao
Summary: Climate change-induced high temperatures have adverse effects on plant growth and development. However, plants have unique heat-resistant strategies, including sensing temperature changes through membrane fluidity, signaling through protein and reactive oxygen species accumulation, conducting heat signals through misfolded proteins, and participating in heat stress response using carbohydrates as signaling molecules.
Article
Plant Sciences
Lin-Feng Wang, Kai-Kai Lu, Ting-Ting Li, Yu Zhang, Jia-Xing Guo, Ru-Feng Song, Wen-Cheng Liu
Summary: In this study, a new phytomelatonin receptor (ZmPMTR1) was identified and examined in maize, and it was found to play an important role in the plant's response to osmotic and drought stress.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Plant Sciences
Chen Xie, Liu Yang, Guixian Jia, Kang Yan, Shizhong Zhang, Guodong Yang, Changai Wu, Yingping Gai, Chengchao Zheng, Jinguang Huang
Summary: A molecular chaperone called ZmHUG1 has been discovered in maize, which positively regulates heat stress tolerance by mitigating heat-induced aggregation of ZmPRA1.C1 protein. The knockout mutant of ZmHUG1 is more sensitive to heat stress and exhibits severe endoplasmic reticulum stress at high temperatures.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Review
Biochemistry & Molecular Biology
Zhaoxia Li, Stephen H. Howell
Summary: High temperatures causing heat stress disrupt cellular homeostasis in plants, leading to growth inhibition. Plants have evolved various responses to heat stress, including cytoplasmic heat stress response and ER-localized unfolded protein response. These heat stress responses could be used as traits for plant breeders to select for thermotolerance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Annalisa Tassone, Giuseppina Martella, Maria Meringolo, Valentina Vanni, Giuseppe Sciamanna, Giulia Ponterio, Paola Imbriani, Paola Bonsi, Antonio Pisani
Summary: The study characterized the cholinergic dysfunction in DYT1 dystonia by analyzing the cholinergic machinery in the dorsal striatum of a DYT1 mouse model. Results showed an increase in vesicular acetylcholine transporter (VAChT) protein level and compensatory enhancement of acetylcholinesterase enzymatic activity in DYT1 mice. Pharmacological activation of dopamine D2 receptors led to abnormal elevation in acetylcholine content, suggesting VAChT as a potential target for pharmacological intervention.
MOVEMENT DISORDERS
(2021)
Article
Plant Sciences
Rosa Vescio, Maria Rosa Abenavoli, Agostino Sorgona
Summary: Plants are constantly exposed to multiple stresses, with their responses showing unique characteristics rather than simple additive effects. Maize roots exhibit varying sensitivity to single and combined stresses, displaying different responses in terms of root types and traits.
Article
Chemistry, Physical
Onur Can Bodur, Elvan Hasanoglu Ozkan, Ozlem Colak, Halit Arslan, Nursen Sari, Ali Disli, Fatma Arslan
Summary: A novel biosensor sensing strategy for sensitive detection of acetylcholine based on PAMAM-Sal dendrimer was designed and developed. A bienzymatic biosensor system with acetylcholine esterase (AChE) and choline oxidase (ChO) was prepared, showing potential for accurate determination of acetylcholine levels. The biosensor's response was studied in terms of pH, temperature, reusability, storage stability, and interference effects of interferants in biological media.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Plant Sciences
Borui Zhang, Huige Gao, Guozhen Wang, Sicong Zhang, Mengru Shi, Yun Li, Zhongqiao Huang, Wensheng Xiang, Wenna Gao, Can Zhang, Xili Liu
Summary: This study found that Guvermectin promotes the growth and tolerance of high temperature stresses in maize, possibly by activation of related pathways. These results suggest that Guvermectin can be developed as a novel plant growth regulator for promoting growth in high temperature environments.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Deniz Mevlevioglu, Sabin Tabirca, David Murphy
Summary: This study assesses the classification of anxiety in Virtual Reality using machine learning classification models and biosensors. Results show that high-accuracy models can be created to determine anxiety in real time. However, there is a lack of standardisation in defining anxiety and the small sample size, mostly consisting of students, may bias the results. Future research should focus on defining anxiety more effectively and expanding the sample size.
Article
Biochemistry & Molecular Biology
Kosuke Yamamoto, Satoshi Shida, Yoshihiro Honda, Mariko Shono, Hiroshi Miyake, Suguru Oguri, Hikaru Sakamoto, Yoshie S. Momonoki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Plant Sciences
Yoshiki Nakahara, Shogo Sawabe, Kenta Kainuma, Maki Katsuhara, Mineo Shibasaka, Masanori Suzuki, Kosuke Yamamoto, Suguru Oguri, Hikaru Sakamoto
FRONTIERS IN PLANT SCIENCE
(2015)
Article
Biochemistry & Molecular Biology
Steffen Riethmueller, Prasath Somasundaram, Johanna C. Ehlers, Chien-Wen Hung, Charlotte M. Flynn, Juliane Lokau, Maria Agthe, Stefan Duesterhoeft, Yijue Zhu, Joachim Groetzinger, Inken Lorenzen, Tomas Koudelka, Kosuke Yamamoto, Ute Pickhinke, Rielana Wichert, Christoph Becker-Pauly, Marisa Raedisch, Alexander Albrecht, Markus Hessefort, Dominik Stahnke, Carlo Unverzagt, Stefan Rose-John, Andreas Tholey, Christoph Garbers
Article
Biochemistry & Molecular Biology
Kosuke Yamamoto, Ahmad Trad, Anja Baumgart, Linda Hueske, Inken Lorenzen, Athena Chalaris, Joachim Groetzinger, Tobias Dechow, Juergen Scheller, Stefan Rose-John
BIOCHEMICAL JOURNAL
(2012)
Article
Biochemistry & Molecular Biology
Sven Malchow, Wolfgang Thaiss, Nathalie Jaenner, Georg H. Waetzig, Jessica Gewiese-Rabsch, Christoph Garbers, Kosuke Yamamoto, Stefan Rose-John, Juergen Scheller
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2011)
Article
Oncology
Ahmad Trad, Hinrich P. Hansen, Mohammad Shomali, Matthias Peipp, Katja Klausz, Nina Hedemann, Kosuke Yamamoto, Andre Mauermann, Christine Desel, Inken Lorenzen, Hilmar Lemke, Stefan Rose-John, Joachim Groetzinger
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2013)
Editorial Material
Pharmacology & Pharmacy
K. Yamamoto, S. Rose-John
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2012)
Article
Gastroenterology & Hepatology
Athena Chalaris, Dirk Schmidt-Arras, Kosuke Yamamoto, Stefan Rose-John
DIGESTIVE DISEASES
(2012)
Article
Agronomy
Yoshie S. Momonoki, Kosuke Yamamoto, Suguru Oguri
PLANT PRODUCTION SCIENCE
(2009)
Article
Biochemistry & Molecular Biology
Kosuke Yamamoto, Yoshie S. Momonoki
Summary: In this study, the presence of propionylcholinesterase (PChE) in rice, acting with hydrolytic activity in the later developmental stages, lower sensitivity to cholinesterase inhibitor, and localization in the extracellular spaces of leaf tissue, was characterized. This discovery provides the first direct evidence and molecular characterization of PChE in plants.
PLANT SIGNALING & BEHAVIOR
(2021)
Article
Plant Sciences
Kosuke Yamamoto, Suguru Oguri, Yoshie S. Momonoki
Article
Biochemistry & Molecular Biology
Kosuke Yamamoto, Yoshie S. Momonoki
PLANT SIGNALING & BEHAVIOR
(2012)
Article
Biochemistry & Molecular Biology
Kosuke Yamamoto, Suguru Oguri, Susumu Chiba, Yoshie S. Momonoki
PLANT SIGNALING & BEHAVIOR
(2009)
Article
Biochemistry & Molecular Biology
Kosuke Yamamoto, Yoshie S. Momonoki
PLANT SIGNALING & BEHAVIOR
(2008)