Journal
JOURNAL OF PLANT BIOLOGY
Volume 53, Issue 5, Pages 321-329Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s12374-010-9126-7
Keywords
Flavonoid; O-Methylation; O-Methyltransferase; Regioselectivity; Substrate specificity
Categories
Funding
- Biogreen 21 Program
- Agenda program (NIAS) [11-30-68]
- Rural Development Administration, Republic of Korea
- Ministry of Education, Science, and Technology [2009-0093824]
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Flavonoids consist of a large family of compounds, which has been estimated to be more than 10,000 compounds. The structural diversity of these compounds comes from different modification reactions. The O-methylation reaction is one of the most important modification reactions of flavonoids and the resulting O-methylated flavonoids have been shown to display new biological activities. The regioselective and substrate specific O-methylation is mediated by O-methyltranferases (OMTs). To date, 30 flavonoid OMTs (FOMTs) have been biochemically characterized from various plants. FOMTs utilize common reaction mechanisms to transfer a methyl group to the hydroxyl group of the flavonoid. Phylogenetic tree analysis along with biochemical characterization of FOMTs provides clues about their substrate specificity and regioselectivity. FOMTs can be used for the production of O-methylated flavonoids that have a particular biological activity.
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