Journal
JOURNAL OF PLANT BIOCHEMISTRY AND BIOTECHNOLOGY
Volume 21, Issue 1, Pages S32-S39Publisher
SPRINGER INDIA
DOI: 10.1007/s13562-012-0134-1
Keywords
WD40 protein; DWD box; beta-propeller; Scaffold; CLR4 ligase
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Funding
- NIPGR core grant
- Department of Biotechnology (DBT), Govt. of India
- Council of Scientific and Industrial Research
- NIPGR, New Delhi
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Plants have been gifted with intricate regulatory networks to carry on with their sessile life form. Often such networks involve delicate association between various proteins. The WD40 proteins, which are present abundantly in several eukaryotes, act as scaffolding molecules assisting proper activity of other proteins. They comprise several stretches of 44-60 amino acid residues and often terminate with a WD dipeptide. They function in several cellular, metabolic and molecular pathways, biologically playing important roles in plant development and also during stress signaling. Moreover, some WD40 (named DWD) proteins also function as substrate receptors in Cullin4 RING dependent E3 ubiquitin ligase mediated proteosomal degradation and DNA damage repair mechanism. In this review, we have discussed the various aspects of these proteins that affect their highly diversified functions in plants.
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