Article
Biochemistry & Molecular Biology
Shi Min Tan, Shaun W. P. Rees, Rebecca E. Jelley, Jin Wang, Bruno Fedrizzi, David Barker
Summary: C-13-norisoprenoids play a vital role in the aroma of grapes and wines. Blumenol B is an important precursor to wine aroma compounds, such as theaspirone and vitispirane. A scalable synthesis route was successfully developed for the enantioselective synthesis of (R,R)-blumenol B, which was further applied to the synthesis of poly-deuterated d9-blumenol B.
Article
Physics, Particles & Fields
Jin-Huan Sheng, Jie Zhu, Quan-Yi Hu
Summary: The passage discusses recent experimental observations of deviations from the Standard Model predictions in semileptonic decays and investigates possible new physics effects of the vector leptoquark in these decays. It highlights the significant contributions of the vector leptoquark to certain observables and the similarity in results between different scenarios of the leptoquark. Additionally, it mentions the hope for future high-energy experiments to test the numerical results obtained in this study.
EUROPEAN PHYSICAL JOURNAL C
(2021)
Article
Chemistry, Multidisciplinary
Jiguo Ma, Qinghai Zhou, Guanshui Song, Yongchang Song, Guoqing Zhao, Kuiling Ding, Baoguo Zhao
Summary: This study presents a method using chiral catalyst to achieve direct asymmetric conjugated addition of NH2-free glycinate with relatively weak electrophiles, successfully synthesizing various chiral products, which can be further converted into Alzheimer's drug Rolipram.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Composites
Xiaodong Xu, Xiaoyang Sun, Michael R. Wisnom
Summary: This study measured initial R-curves for different in-plane sizes and stacking sequences, finding that all sizes showed linearly increasing trends without a full R-curve plateau. X-ray Computed Tomography was used to measure crack length throughout fracture propagation.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Article
Immunology
Heng-Mo Rong, Chao Zhang, Guang-Sheng Rong, Ting Li, Xiao-Jun Qian, Dong Wang, Zhao-Hui Tong
Summary: This study investigated the role of mature B cells in the pathogenesis and progression of PCP, and found that BAFF-R deficiency plays a significant role in immune regulation in the PCP population. This was demonstrated through analysis of lncRNA and mRNA expression profiles.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Materials Science, Ceramics
Guohua Fan, Xiaoping Zhang, Qingyu Wang, Ran Su, Yanan Tang, Chuncheng Hao, Yao Liu
Summary: In this study, TiN/BaTiO3 ceramic composites were prepared and the influence of percolation on their conductivity, impedance, and permittivity was investigated. The plasma oscillations of free electrons in percolation networks were found to be the key factor causing the permittivity of the ceramics to change from positive to negative. Furthermore, the percolation networks provided pathways for electron migration and achieved high conductivity.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Manufacturing
L. F. Varandas, D. Dalli, G. Catalanotti, B. G. Falzon
Summary: A three-dimensional micromechanics framework is developed to estimate the mode I through-thickness intralaminar crack resistance curve of unidirectional carbon fibre-reinforced polymers. The size effect law and crack resistance curve are estimated through numerically calculated peak stresses. Parametric analyses are conducted to compare with experimental and numerical observations.
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2022)
Article
Mathematics, Applied
I. M. Taha
Summary: This paper introduces the notions of fuzzy soft almost (resp. weakly) r-minimal continuous mappings as a weaker form of fuzzy soft r-minimal continuity by Taha (2021), and provides some properties. It is also shown that every fuzzy soft r-minimal continuity is fuzzy soft almost (resp. weakly) r-minimal continuity, but the converse may not hold. Furthermore, the concept of continuity in a very general setting called fuzzy soft r-minimal (A, B, C, D)-continuous mappings is introduced and some properties of these mappings are investigated.
Article
Chemistry, Organic
Mallepalli Shankar, K. C. Kumara Swamy
Summary: A Cu(II)-catalyzed decarboxylative oxidative (4 + 2) annulation of coumarin-3-carboxylic acids with tert-propargylic alcohols has been developed. The protocol involves the in situ generation of alpha,beta-unsaturated carbonyl compounds by the Meyer-Schuster rearrangement, leading to the synthesis of diverse naphthochromenone architectures in good to excellent yields.
Article
Medicine, General & Internal
Yuanzheng Liang, Xindi Liu, Jing Yang, Henan Wang, Yingshi Piao, Liqiang Wei, Liang Wang
Summary: This study compared the efficacy and safety of DA-EPOCH-R with R-CHOP in WR-DLBCL patients. The results showed that DA-EPOCH-R had superior progression-free survival, overall survival, and controlled toxicity compared to R-CHOP, with no significant differences in clinical responses and treatment-related toxicities between the two groups.
CHINESE MEDICAL JOURNAL
(2023)
Article
Immunology
Wei Luo, Laura Conter, Rebecca A. Elsner, Shuchi Smita, Florian Weisel, Derrick Callahan, Shuxian Wu, Maria Chikina, Mark Shlomchik
Summary: IL-21R plus CD40 signals have different effects on germinal center B cells compared with BCR plus CD40 signals, leading to the differentiation of a subset of cells into plasma cells, representing a second positive selection pathway.
SCIENCE IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bernhard Schlevogt, Klaus H. W. Boeker, Stefan Mauss, Hartwig Klinker, Renate Heyne, Ralph Link, Karl-Georg Simon, Christoph Sarrazin, Yvonne Serfert, Michael P. Manns, Heiner Wedemeyer
Summary: The study indicates that patients receiving interferon-free antiviral treatment for chronic hepatitis C experience significant weight gain during long-term follow-up, with non-obese patients being more vulnerable to weight gain. A body mass index (BMI) < 30 was the only consistent predictor for weight gain, suggesting that non-obese individuals are more likely to gain weight after DAA treatment.
Article
Mechanics
Xun Wu, Michael R. Wisnom
Summary: One of the major difficulties in determining the compressive strengths of composites is the stress concentration and strain gradient effect. In this study, unconventional flexural tests were conducted on carbon fibre/wood sandwich and monolithic composite beams to obtain reliable compressive failure strains. The results showed high values and low variability, with the compressive strain of IM7/8552 material being 1.36% higher than previously published values and only 3% variability. Additionally, the strain gradient effect on compressive failure strain was analyzed for the first time using different wood core depths, with the effect decreasing with increased beam thickness.
COMPOSITE STRUCTURES
(2023)
Article
Food Science & Technology
Masahiro Nagahama, Keiko Kobayashi, Sadayuki Ochi, Masaya Takehara
Summary: Clostridium botulinum C2 toxin requires lysosomal enzyme cathepsin B (CTSB) for effective cellular entry, with cysteine protease and aspartyl protease having different effects on cell rounding and extracellular ASMase activity induced by C2 toxin.
Article
Engineering, Mechanical
Benjamin C. Cameron, C. Cem Tasan
Summary: This article presents a system of partial differential equations (PDEs) to calculate the full-field stress from an observed kinematic field when the flow rule governing the plastic deformation is unknown. These equations generalize previously proposed equations that assume pure plastic behavior without elasticity. A method to numerically solve these equations is also presented.
INTERNATIONAL JOURNAL OF PLASTICITY
(2023)
Editorial Material
Physiology
Sue C. Bodine, Oleg I. Orlov, Anatoly I. Grigoriev, Elena S. Tomilovskaya, Boris S. Shenkman
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Cell Biology
David C. Hughes, Leslie M. Baehr, Julia R. Driscoll, Sarah A. Lynch, David S. Waddell, Sue C. Bodine
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Editorial Material
Physiology
Josephine C. Adams, P. Darwin Bell, Sue C. Bodine, Heddwen L. Brooks, Nigel Bunnett, Bina Joe, Kara Hansell Keehan, Thomas R. Kleyman, Andre Marette, Rory E. Morty, Jan-Marino Ramirez, Morten B. Thomsen, Bill J. Yates, Irving H. Zucker
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Editorial Material
Physiology
Sue C. Bodine, Rory E. Morty
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Article
Cell Biology
David C. Hughes, Daniel C. Turner, Leslie M. Baehr, Robert A. Seaborne, Mark Viggars, Jonathan C. Jarvis, Piotr P. Gorski, Claire E. Stewart, Daniel J. Owens, Sue C. Bodine, Adam P. Sharples
Summary: The study demonstrates the important role of UBR5 in anabolism and hypertrophy, with knockdown of UBR5 resulting in skeletal muscle atrophy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Physiology
Luis G. O. de Sousa, Andrea G. Marshall, Jennifer E. Norman, Jordan D. Fuqua, Vitor A. Lira, John C. Rutledge, Sue C. Bodine
Summary: The study demonstrates that high-fat diets do not impact muscle mass, contractile function, or protein synthesis in obese C57BL/6 mice, but delay load-induced growth. Only a 45% high-fat diet resulted in attenuated growth following 30 days of functional overload.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Editorial Material
Physiology
Sue C. Bodine, Heddwen L. Brooks, Nigel W. Bunnett, Hilary A. Coller, Mark R. Frey, Bina Joe, Thomas R. Kleyman, Merry L. Lindsey, Andre Marette, Rory E. Morty, Jan-Marino Ramirez, Morten B. Thomsen, Gina L. C. Yosten
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Arik Davidyan, Suraj Pathak, Keith Baar, Sue C. Bodine
Summary: Research suggests that testosterone may not be critical for the maintenance of muscle mass in mature male mice within physiological serum concentrations, but is crucial for normal growth in young mice.
Article
Biochemistry & Molecular Biology
Nelson E. Bruno, Jerome C. Nwachukwu, David C. Hughes, Sathish Srinivasan, Richard Hawkins, David Sturgill, Gordon L. Hager, Stephen Hurst, Shey-Shing Sheu, Sue C. Bodine, Michael D. Conkright, Kendall W. Nettles
Summary: Crtc2 overexpression in skeletal muscle leads to metabolic adaptations, increasing mitochondrial activity and energy expenditure, reducing fat and maintaining muscle mass, improving glucose handling and insulin sensitivity. Crtc2/Creb1-mediated signaling reverses the downregulation of mitochondrial genes induced by ADF, and counteracts muscle atrophy caused by glucocorticoids and AMPK.
Editorial Material
Biochemistry & Molecular Biology
Leslie M. Baehr, David C. Hughes, David S. Waddell, Sue C. Bodine
Review
Biochemistry & Molecular Biology
David C. Hughes, Leslie M. Baehr, David S. Waddell, Adam P. Sharples, Sue C. Bodine
Summary: The development and prevalence of diseases associated with aging have a global health burden on society. One hallmark of aging is the loss of proteostasis, partly caused by alterations to the ubiquitin-proteasome system and lysosome-autophagy system, leading to impaired function and maintenance of mass in tissues such as skeletal muscle. In skeletal muscle, functional impairment occurs early in the aging process and depends on proteostatic mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Physiology
Sue C. Bodine, Rory E. Morty
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Editorial Material
Physiology
Sue C. Bodine, Heddwen L. Brooks, Hilary A. Coller, Ana I. Domingos, Mark R. Frey, Barbara E. Goodman, Thomas R. Kleyman, Merry L. Lindsey, Rory E. Morty, Ole H. Petersen, Jan-Marino Ramirez, Liliana Schaefer, Morten B. Thomsen, Gina L. C. Yosten
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Neurosciences
Colleen L. O'Reilly, Sue C. Bodine, Benjamin F. Miller
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Cell Biology
Leslie M. Baehr, David C. Hughes, Sarah A. Lynch, Delphi Van Haver, Teresa Mendes Maia, Andrea G. Marshall, Lilliana Radoshevich, Francis Impens, David S. Waddell, Sue C. Bodine
Summary: MuRF1 is a muscle-specific E3 ubiquitin ligase that is upregulated under conditions of muscle loss. Overexpression of MuRF1 leads to muscle atrophy by targeting both thick and thin filament contractile proteins as well as metabolic enzymes and other proteolytic pathways.
