Atrial selectivity of antiarrhythmic drugs

The new antiarrhythmic drug vernakalant: ex vivo study of human atrial tissue from sinus rhythm and chronic atrial fibrillation

(2013) Erich Wettwer et al.   CARDIOVASCULAR RESEARCH

Rotors and the Dynamics of Cardiac Fibrillation

(2013) Sandeep V. Pandit et al.   CIRCULATION RESEARCH

Transient Receptor Potential (TRP) Channels and Cardiac Fibrosis

(2013) Zhichao Yue et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Human Electrophysiological and Pharmacological Properties of XEN-D0101

(2013) John Ford et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

KCNJ2mutation in short QT syndrome 3 results in atrial fibrillation and ventricular proarrhythmia

(2013) Makarand Deo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Receptor Potential Canonical-3 Channel–Dependent Fibroblast Regulation in Atrial Fibrillation

(2012) Masahide Harada et al.   CIRCULATION

Rate-Dependent Effects of Vernakalant in the Isolated Non-Remodeled Canine Left Atria Are Primarily Due to Block of the Sodium Channel

(2012) Alexander Burashnikov et al.   Circulation-Arrhythmia and Electrophysiology

MK-0448, a Specific Kv1.5 Inhibitor

(2012) Behzad B. Pavri et al.   Circulation-Arrhythmia and Electrophysiology

2012 focused update of the ESC Guidelines for the management of atrial fibrillation

(2012) et al.   EUROPACE

The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities

(2012) S. Nattel et al.   EUROPEAN HEART JOURNAL

Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation

(2012) Ingrid E. Christophersen et al.   EUROPEAN HEART JOURNAL

Novel molecular targets for atrial fibrillation therapy

(2012) Dobromir Dobrev et al.   NATURE REVIEWS DRUG DISCOVERY

Computational Mapping Identifies Localized Mechanisms for Ablation of Atrial Fibrillation

(2012) Sanjiv M. Narayan et al.   PLoS One

Ultra-rapid delayed rectifier channels: molecular basis and therapeutic implications

(2011) U. Ravens et al.   CARDIOVASCULAR RESEARCH

Atrial Fibrillation

(2011) Jared W. Magnani et al.   CIRCULATION

Recent advances in the molecular pathophysiology of atrial fibrillation

(2011) Reza Wakili et al.   JOURNAL OF CLINICAL INVESTIGATION

Pathophysiological Mechanisms of Atrial Fibrillation: A Translational Appraisal

(2011) Ulrich Schotten et al.   PHYSIOLOGICAL REVIEWS

Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation

(2010) L. Yue et al.   CARDIOVASCULAR RESEARCH

TRPM7-Mediated Ca 2+ Signals Confer Fibrogenesis in Human Atrial Fibrillation

(2010) Jianyang Du et al.   CIRCULATION RESEARCH

Genetics of Atrial Fibrillation

(2010) Steven A. Lubitz et al.   Circulation-Arrhythmia and Electrophysiology

Effects of a Highly Selective Acetylcholine-Activated K + Channel Blocker on Experimental Atrial Fibrillation

(2010) Taiichi Machida et al.   Circulation-Arrhythmia and Electrophysiology

Altered Na+Currents in Atrial Fibrillation

(2010) Samuel Sossalla et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Antiarrhythmic therapy in atrial fibrillation

(2010) Ursula Ravens   PHARMACOLOGY & THERAPEUTICS

Animal models for atrial fibrillation: clinical insights and scientific opportunities

(2009) K. Nishida et al.   EUROPACE

Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference ‘research perspectives in AF’

(2009) Paulus Kirchhof et al.   EUROPEAN HEART JOURNAL

Atrial-selective sodium channel block for the treatment of atrial fibrillation

(2009) Alexander Burashnikov et al.   EXPERT OPINION ON EMERGING DRUGS

IKur/Kv1.5 channel blockers for the treatment of atrial fibrillation

(2009) Juan Tamargo et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Characterization of In Vivo and In Vitro Electrophysiological and Antiarrhythmic Effects of a Novel IKACh Blocker, NIP-151: A Comparison With an IKr-Blocker Dofetilide

(2009) Norio Hashimoto et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Improving cardiac gap junction communication as a new antiarrhythmic mechanism: the action of antiarrhythmic peptides

(2009) Stefan Dhein et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation

(2009) Niels Voigt et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Pathology-specific effects of the IKur/Ito/IK,ACh blocker AVE0118 on ion channels in human chronic atrial fibrillation

(2008) T Christ et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-arrhythmic drug therapy for atrial fibrillation: current anti-arrhythmic drugs, investigational agents, and innovative approaches

(2008) I. Savelieva et al.   EUROPACE

Can inhibition of IKur promote atrial fibrillation?

(2008) Alexander Burashnikov et al.   HEART RHYTHM

A mutation in the sodium channel is responsible for the association of long QT syndrome and familial atrial fibrillation

(2008) Begoña Benito et al.   HEART RHYTHM

New Drugs Targeting the Cardiac Ultra-Rapid Delayed-Rectifier Current (IKur): Rationale, Pharmacology and Evidence for Potential Therapeutic Value

(2008) John W Ford et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Atrial Fibrosis: Mechanisms and Clinical Relevance in Atrial Fibrillation

(2008) Brett Burstein et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pathophysiology and pharmacology of the cardiac “late sodium current”

(2008) Antonio Zaza et al.   PHARMACOLOGY & THERAPEUTICS

Late sodium current in failing heart: Friend or foe?

(2007) Victor A. Maltsev et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY