CrossTalk proposal: There is added benefit to providing permissive hypercapnia in the treatment of ARDS

Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-κB–dependent mechanism

(2012) Maya Contreras et al.   CRITICAL CARE MEDICINE

Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis

(2010) Joseph Costello et al.   CRITICAL CARE MEDICINE

NF- B Links CO2 Sensing to Innate Immunity and Inflammation in Mammalian Cells

(2010) E. P. Cummins et al.   JOURNAL OF IMMUNOLOGY

Therapeutic effects of hypercapnia on chronic lung injury and vascular remodeling in neonatal rats

(2009) Azhar Masood et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury*

(2009) Donall F. O’Croinin et al.   CRITICAL CARE MEDICINE

Impact of acute hypercapnia and augmented positive end-expiratory pressure on right ventricle function in severe acute respiratory distress syndrome

(2009) Armand Mekontso Dessap et al.   INTENSIVE CARE MEDICINE

Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF- B dependent mechanism

(2009) D O'Toole et al.   THORAX

Effects of a Clinical Trial on Mechanical Ventilation Practices in Patients with Acute Lung Injury

(2008) William Checkley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hypercapnic Acidosis Attenuates Lung Injury Induced by Established Bacterial Pneumonia

(2008) Martina Ni Chonghaile et al.   ANESTHESIOLOGY

Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by a neutrophil-independent mechanism*

(2008) Martina Ni Chonghaile et al.   CRITICAL CARE MEDICINE

Acute Hypercapnia Improves Indices of Tissue Oxygenation More than Dobutamine in Septic Shock

(2007) Zhen Wang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE