G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function

Group I Metabotropic Glutamate Receptor Signalling and its Implication in Neurological Disease

(2012) Fabiola M. Ribeiro et al.   CNS & Neurological Disorders-Drug Targets

Nuclear GPCRs in cardiomyocytes: an insider's view of β-adrenergic receptor signaling

(2011) George Vaniotis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Identification of Transcription Factor E3 (TFE3) as a Receptor-independent Activator of Gα16

(2011) Motohiko Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracrine action of angiotensin II in the intact ventricle of the failing heart: angiotensin II changes cardiac excitability from within

(2011) Walmor C. De Mello   MOLECULAR AND CELLULAR BIOCHEMISTRY

Local angiotensin II aggravates cardiac remodeling in hypertension

(2010) Jiang Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nitric oxide and reactive oxygen species in the nucleus revisitedThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Chantale Provost et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Gβγ is a negative regulator of AP-1 mediated transcription

(2010) Mélanie Robitaille et al.   CELLULAR SIGNALLING

Nuclear β-adrenergic receptors modulate gene expression in adult rat heart

(2010) George Vaniotis et al.   CELLULAR SIGNALLING

Cell Communications in the Heart

(2010) Daniela Tirziu et al.   CIRCULATION

Nuclear-delimited Angiotensin Receptor-mediated Signaling Regulates Cardiomyocyte Gene Expression

(2010) Artavazd Tadevosyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracrine signalling of activin A in hepatocytes upregulates connective tissue growth factor (CTGF/CCN2) expression

(2010) Olav A. Gressner et al.   LIVER INTERNATIONAL

Exploring the Binding Site Crevice of a Family B G Protein-Coupled Receptor, the Type 1 Corticotropin Releasing Factor Receptor

(2010) K. Gkountelias et al.   MOLECULAR PHARMACOLOGY

Cross-Talk between ROS and Calcium in Regulation of Nuclear Activities

(2010) Christian Mazars et al.   Molecular Plant

Nuclear localization of vasoactive intestinal peptide (VIP) receptors in human breast cancer

(2010) Ana Valdehita et al.   PEPTIDES

The Human Gonadotropin Releasing Hormone Type I Receptor Is a Functional Intracellular GPCR Expressed on the Nuclear Membrane

(2010) Michelle Re et al.   PLoS One

Regulation of RhoGEF proteins by G12/13-coupled receptors

(2009) Sandra Siehler   BRITISH JOURNAL OF PHARMACOLOGY

Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways

(2009) Jeffrey J. Kovacs et al.   DEVELOPMENTAL CELL

Preservation of Intracellular Renin Expression Is Insufficient to Compensate for Genetic Loss of Secreted Renin

(2009) Di Xu et al.   HYPERTENSION

Intracellular Metabotropic Glutamate Receptor 5 (mGluR5) Activates Signaling Cascades Distinct from Cell Surface Counterparts

(2009) Yuh-Jiin I. Jong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Signaling, Internalization, and Nuclear Localization of the Angiotensin Converting Enzyme in Smooth Muscle and Endothelial Cells

(2009) Héctor A. Lucero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An update on nuclear calcium signalling

(2009) M. D. Bootman et al.   JOURNAL OF CELL SCIENCE

Renin–angiotensin system component expression in the HL-1 atrial cell line and in a pig model of atrial fibrillation

(2009) Chia-Ti Tsai et al.   JOURNAL OF HYPERTENSION

The Year In G Protein-Coupled Receptor Research

(2009) Robert P. Millar et al.   MOLECULAR ENDOCRINOLOGY

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Growth Hormone Internalization in Mitochondria Decreases Respiratory Chain Activity

(2009) Dominique Ardail et al.   NEUROENDOCRINOLOGY

The neurokinin-3 (NK3) and the neurokinin-1 (NK1) receptors are differentially targeted to mesocortical and mesolimbic projection neurons and to neuronal nuclei in the rat ventral tegmental area

(2009) Andrée Lessard et al.   SYNAPSE

Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum

(2009) Christy A. Barlow et al.   TRENDS IN CELL BIOLOGY

Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors

(2009) Davide Calebiro et al.   PLOS BIOLOGY

Intracellular ANG II directly induces in vitro transcription of TGF-β1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1a receptors

(2008) Xiao C. Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production

(2008) Vivek P. Singh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Activation of ETB receptors regulates the abundance of ET-1 mRNA in vascular endothelial cells

(2008) N Farhat et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nonpeptidic antagonists of ETA and ETB receptors reverse the ET-1-induced sustained increase of cytosolic and nuclear calcium in human aortic vascular smooth muscle cellsThis article is one of a selection of papers published in the special issue (part 2 of 2) on Forefronts in Endothelin.

(2008) Ghassan Bkaily et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

Nuclear α1-Adrenergic Receptors Signal Activated ERK Localization to Caveolae in Adult Cardiac Myocytes

(2008) Casey D. Wright et al.   CIRCULATION RESEARCH

Intracellular Angiotensin II Production in Diabetic Rats Is Correlated With Cardiomyocyte Apoptosis, Oxidative Stress, and Cardiac Fibrosis

(2008) V. P. Singh et al.   DIABETES

ACE-Dependent and Chymase-Dependent Angiotensin II Generation in Normal and Glucose-Stimulated Human Mesangial Cells

(2008) Priscila C. Cristovam et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Activated Nuclear Metabotropic Glutamate Receptor mGlu5 Couples to Nuclear Gq/11Proteins to Generate Inositol 1,4,5-Trisphosphate-mediated Nuclear Ca2+Release

(2008) Vikas Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of endogenous nuclear bradykinin B2 receptors mediating signaling in immediate early gene activation

(2008) Martin Savard et al.   JOURNAL OF CELLULAR PHYSIOLOGY

G Protein-Coupled Receptors in and on the Cell Nucleus: A New Signaling Paradigm?

(2008) BENOIT BOIVIN et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Regulation of GPCRs by Endocytic Membrane Trafficking and Its Potential Implications

(2007) Aylin C. Hanyaloglu et al.   Annual Review of Pharmacology and Toxicology

A Functional Nuclear Localization Signal in Insulin-Like Growth Factor Binding Protein-6 Mediates Its Nuclear Import

(2007) Cristiana Iosef et al.   ENDOCRINOLOGY