Article
Pharmacology & Pharmacy
Shang Xian Bo, Wang Yan Jie, Cai De Chao, Ma Sai, Wang Zhe, Zhu Ya Kun, Guo Hui Hui, Wang Chen, Ma Xiao, Hu Zhong Yao, Yu Hao Ran, Zhang Ji Sen, Cheng Wen Dan
Summary: The study demonstrated that compound 22o effectively inhibited the inflammatory response and catabolism of chondrocytes, reducing articular cartilage injury in a rat OA model induced by ACLT. The compound showed potential as a disease-modifying OA drug.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Chao Xia, Yonghui Wang, Tianyuan Jiang, Yan Hu, Yang Chen, Xinrun Ma, Xuemei Zhang, Yanhong Gao
Summary: The study found that Slo1 deficiency impairs skeletal muscle regeneration and slow-twitch fiber formation.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Plant Sciences
Jeremy Astier, Jordan Rossi, Pauline Chatelain, Agnes Klinguer, Angelique Besson-Bard, Claire Rosnoblet, Sylvain Jeandroz, Valerie Nicolas-Frances, David Wendehenne
Summary: The study of nitric oxide in embryophytes and algae has deepened our understanding of its biological functions, including its production pathways, signaling networks, and regulated proteins. Interestingly, while some algae have a conserved nitric oxide synthase, the typical NO-cyclic GMP signaling module is not found in algae or embryophytes, showing a divergent acquisition of NO signaling between green and animal lineages.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Ulises Novoa, Karen Soto, Cristian Valdes, Jorge Villasenor, Adriana Treuer, Daniel R. Gonzalez
Summary: This study found that treatment with BH4 can prevent the development of diabetic cardiomyopathy and nephropathy. BH4 treatment reduced cardiac hypertrophy and fibrosis, as well as glomerular hypertrophy and fibrosis. These results suggest that BH4-based treatment may ameliorate the cardiorenal effects of diabetes by restoring the nitroso-redox balance.
Article
Geriatrics & Gerontology
Hyun-Jun Kim, Seon-Wook Kim, Sang-Hoon Lee, Da-Woon Jung, Darren R. Williams
Summary: This study found that Alox5 is a regulator and drug target for muscle atrophy, and the drug malotilate can be repurposed as a treatment for muscle atrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Biochemistry & Molecular Biology
Jennifer A. Miles, Joseph L. Egan, Jake A. Fowler, Petrina Machattou, Andrew D. Millard, Christopher J. Perry, David J. Scanlan, Paul C. Taylor
Summary: Research suggests that eNOS and NOX5 may have been horizontally transferred from ancestral cyanobacteria to ancestral eukaryotes. Studies on homologues of these enzymes in other organisms could provide insights into the production of superoxide, nitric oxide, and peroxynitrite in humans.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Tao Yan, Shun Guo, Tian Zhang, Zhimin Zhang, An Liu, Song Zhang, Yuan Xu, Yuhong Qi, Weihe Zhao, Qinhui Wang, Lei Shi, Linna Liu
Summary: The study evaluated the protective effects of LIG on radiation enteritis (RE), showing that LIG significantly improved body weights, stool morphologies, intestinal villi lengths, perfusion, and vasodilatory functions in IR rats. LIG also improved Gch1/BH4/eNOS pathway-related proteins and regulatory molecules, indicating it as a preferred compound for the prevention and treatment of RE by improving intestinal ischemia. This study provides new research ideas for the development of new drugs for RE.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Jeffrey Kingsley, Keiichi Torimoto, Tomoki Hashimoto, Satoru Eguchi
Summary: Sarcopenia is characterized by progressive loss of muscle mass and strength, leading to increased risks of falls, fractures, disability, and death. The causes are multifactorial, including genetics, aging, immobility, nutritional deficiencies, inflammation, stress, and endocrine factors. Prevention or reduction of sarcopenia requires exploring new treatment methods.
Article
Multidisciplinary Sciences
Perrine Delers, Delphine Sapaly, Badih Salman, Stephan De Waard, Michel De Waard, Suzie Lefebvre
Summary: Deficiency of SMN protein causes spinal muscular atrophy (SMA) and flunarizine has been shown to improve NMJs in SMA model mice. This study further uncovers that flunarizine promotes AChR clustering in a cell-autonomous and dose-dependent manner. It also affects the expression and interaction of key proteins involved in the NMJ biology, such as LRP4, integrin-beta-1, and MuSK.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Xiaofan Yang, Pingping Xue, Zhenyu Liu, Wenqing Li, Chuyan Li, Zhenbing Chen
Summary: Through experiments, it was found that SESN2 can prevent the transition from slow-twitch to fast-twitch myofibers, and preserve muscle mass in denervated atrophy. Additionally, SESN2 can activate AMPK/PGC-1 alpha signaling, which further induces the expression of hypoxia-inducible factor HIF2 alpha.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Daniel Kruglyakov, Shashank Kumar Ojha, Maryam Kartawy, Manish Kumar Tripathi, Wajeha Hamoudi, Wisam Bazbaz, Igor Khaliulin, Haitham Amal
Summary: Glioblastoma multiforme (GBM) is a prevalent and aggressive primary brain tumor. This study found that elevated levels of nitric oxide (NO.) and dysregulated activity of nitric oxide synthase (NOS) enzymes are characteristic of GBM. Targeted intervention with specific inhibitors of NOS enzymes led to decreased NO. levels and cell proliferation in GBM. These findings suggest that NO. and NOS enzymes could be potential therapeutic targets for GBM.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Physiology
Ashenafi H. Betrie, Shuai Ma, Connie P. C. Ow, Rachel M. Peiris, Roger G. Evans, Scott Ayton, Darius J. R. Lane, Adam Southon, Simon R. Bailey, Rinaldo Bellomo, Clive N. May, Yugeesh R. Lankadeva
Summary: In ovine sepsis, renal medullary hypoperfusion and hypoxia precede acute kidney injury (AKI). Tempol, an antioxidant and anti-inflammatory drug, can protect renal medullary perfusion and oxygenation, decrease the occurrence of AKI, and reduce the expression of tumor necrosis factor alpha (TNF-α) and uncoupling of endothelial nitric oxide synthase (eNOS). However, it does not affect markers of oxidative/nitrosative stress, which are significantly decreased during Gram-negative sepsis.
Article
Audiology & Speech-Language Pathology
Bas M. J. Olthof, Dominika Lyzwa, Sarah E. Gartside, Adrian Rees
Summary: The anti-inflammatory drug salicylate has been found to induce tinnitus in animals and humans. This study investigated the mechanism behind salicylate-induced hyperactivity in the inferior colliculus, a region in the auditory midbrain. The results suggest that the hyperactivity is mediated by nitric oxide signaling and is dependent on an ascending glutamatergic input.
Article
Plant Sciences
Tae-Hoon Kim, Ji-Yoon Kim, Jieun Bae, Young-Mi Kim, Moo-Ho Won, Kwon-Soo Ha, Young-Guen Kwon, Young-Myeong Kim
Summary: The study demonstrated that Korean Red ginseng extract (KRGE) delayed or prevented the senescence of human umbilical vein endothelial cells (HUVECs) through a signaling cascade involving the induction of HO-1, inhibition of NF-kappa B-dependent miR-155-5p biogenesis, and maintenance of the eNOS/NO axis activity.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ji Won Park, Barbora Piknova, Peter J. Walter, Hongyi Cai, Supranee Upanan, Samantha M. Thomas, Khalid J. Tunau-Spencer, Alan N. Schechter
Summary: This study found that dietary nitrate is rapidly absorbed and converted into nitrite, thereby increasing the availability of nitrite and nitric oxide in the body. This suggests that nitrate-enriched diets can effectively enhance the bioavailability of nitrite and nitric oxide.
SCIENTIFIC REPORTS
(2023)
Article
Fisheries
Alejandro Villasante, Madison S. Powell, Katerina Moutou, Gordon K. Murdoch, Ken Overturf, Jurij Wacyk, Ronald W. Hardy
Article
Biochemistry & Molecular Biology
Alejandro Villasante, Madison S. Powell, Gordon K. Murdoch, Ken Overturf, Kenneth Cain, Jurij Wacyk, Ronald W. Hardy
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2016)
Article
Agriculture, Multidisciplinary
Kara J. Thornton, Kalyan C. Chapalamadugu, Eric M. Eldredge, Gordon K. Murdoch
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2017)
Article
Food Science & Technology
M. J. Colle, J. A. Nasados, J. M. Rogers, D. M. Kerby, M. M. Colle, J. B. Van Buren, R. P. Richard, G. K. Murdoch, C. J. Williams, M. E. Doumit
Article
Agriculture, Dairy & Animal Science
C. C. Reichhardt, A. Ahmadpour, R. G. Christensen, N. E. Ineck, G. K. Murdoch, K. J. Thornton
Summary: This study aimed to investigate the effects of polyamines and their precursors on bovine satellite cell proliferation rate, as well as the impact of trenbolone acetate on the polyamine biosynthetic pathway.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
James R. Vinyard, Cheyanne A. Myers, Gordon K. Murdoch, Pedram Rezamand, Gwinyai E. Chibisa
Summary: The study investigated the optimal proportion of grape pomace (GP) in finishing cattle diets, finding that a dietary inclusion level beyond 15% might compromise nutrient supply and growth performance. Responses to dietary GP proportion were mostly quadratic, indicating potential compromised nutrient supply.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Genetics & Heredity
Morgan R. Stegemiller, Gordon K. Murdoch, Troy N. Rowan, Kimberly M. Davenport, Gabrielle M. Becker, John B. Hall, Brenda M. Murdoch
Summary: This study identified significant loci associated with beef cattle fertility using GWAS, with loci on chromosome 2 being significant in both AFC and RTS analyses. These regions contained genes associated with cell proliferation, transcription, apoptosis, and development.
Article
Agriculture, Dairy & Animal Science
Caleb C. Reichhardt, Lillian L. Okamoto, Laura A. Motsinger, Brian P. Griffin, Gordon K. Murdoch, Kara J. Thornton
Summary: The study found that polyamine precursors and polyamines influence the differentiation of BSC, while steroidal hormones alter the abundance of mRNA involved in polyamine biosynthesis.
Article
Endocrinology & Metabolism
Yao Gao, Liang Zhao, Jun Seok Son, Xiangdong Liu, Yanting Chen, Jeanene Marie Deavila, Mei-Jun Zhu, Gordon K. Murdoch, Min Du
Summary: Maternal exercise promotes thyroid hormone delivery to embryos and enhances embryonic myogenesis through enhanced thyroid hormone signaling.
Article
Agriculture, Dairy & Animal Science
Jessica M. Lancaster, Brianna J. Buseman, Tanya M. Weber, James A. Nasados, Ron P. Richard, Gordon K. Murdoch, William J. Price, Michael J. Colle, Phillip D. Bass
TRANSLATIONAL ANIMAL SCIENCE
(2020)
Article
Neurosciences
Gabryel Conley Natividad, Sophia K. Theodossiou, Nathan R. Schiele, Gordon K. Murdoch, Alkiviadis Tsamis, Bertrand Tanner, Gabriel Potirniche, Martin Mortazavi, David A. Vorp, Bryn A. Martin
FLUIDS AND BARRIERS OF THE CNS
(2020)
Article
Agriculture, Dairy & Animal Science
Kacie C. Hoffman, Michael J. Colle, James A. Nasados, Sara J. Gray, Jakobie Rogers, Jessie B. Van Buren, Kendelle J. Puga, Gordon K. Murdoch, Ronald P. Richard, Matthew E. Doumit
TRANSLATIONAL ANIMAL SCIENCE
(2020)
Article
Agriculture, Dairy & Animal Science
Tanya M. Weber, Brianna J. Buseman, James A. Nasados, Jessica M. Lancaster, Jessie B. Van Buren, Jaxon H. Smart, Phillip D. Bass, Gordon K. Murdoch, Kizkitza Insausti, Michael J. Colle
TRANSLATIONAL ANIMAL SCIENCE
(2020)
Article
Biophysics
Rabijit Dutta, Tao Xing, Gordon K. Murdoch
PHYSIOLOGICAL MEASUREMENT
(2018)
Article
Biophysics
Rabijit Dutta, Tao Xing, Craig Swanson, Jeff Heltborg, Gordon K. Murdoch
PHYSIOLOGICAL MEASUREMENT
(2018)