Physiological mechanisms for the modulation of pannexin 1 channel activity

Pannexin: From discovery to bedside in 11±4 years?

(2012) Gerhard Dahl et al.   BRAIN RESEARCH

ATP signaling is deficient in cultured pannexin1-null mouse astrocytes

(2012) Sylvia O. Suadicani et al.   GLIA

Pannexin1 Drives Multicellular Aggregate Compaction via a Signaling Cascade That Remodels the Actin Cytoskeleton

(2012) Brian A. Bao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pannexin 1, an ATP Release Channel, Is Activated by Caspase Cleavage of Its Pore-associated C-terminal Autoinhibitory Region

(2012) Joanna K. Sandilos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Pannexin 1 Attenuates Melanoma Progression by Reversion to a Melanocytic Phenotype

(2012) Silvia Penuela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Opposing effects of ATP and adenosine on barrier function of rat coronary microvasculature

(2012) Dursun Gündüz et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Anoxia-Induced NMDA Receptor Activation Opens Pannexin Channels via Src Family Kinases

(2012) N. L. Weilinger et al.   JOURNAL OF NEUROSCIENCE

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

(2012) Robert E Sorge et al.   NATURE MEDICINE

Thrombin-induced ATP release from human umbilical vein endothelial cells

(2011) Stefanie Gödecke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Pannexin channels are not gap junction hemichannels

(2011) Gina E. Sosinsky et al.   Channels

Pannexin1 Regulates α1-Adrenergic Receptor– Mediated Vasoconstriction

(2011) Marie Billaud et al.   CIRCULATION RESEARCH

Expression and Roles of Pannexins in ATP Release in the Pituitary Gland

(2011) Shuo Li et al.   ENDOCRINOLOGY

Two non-vesicular ATP release pathways in the mouse erythrocyte membrane

(2011) Feng Qiu et al.   FEBS LETTERS

Characterization of novel Pannexin 1 isoforms from rat pituitary cells and their association with ATP-gated P2X channels

(2011) Shuo Li et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

A Loss-of-Function Polymorphism in the Human P2X4 Receptor Is Associated With Increased Pulse Pressure

(2011) Leanne Stokes et al.   HYPERTENSION

Rho Signaling Regulates Pannexin 1-mediated ATP Release from Airway Epithelia

(2011) Lucia Seminario-Vidal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathways Regulating the Trafficking and Turnover of Pannexin1 Protein and the Role of the C-terminal Domain

(2011) Ruchi Gehi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The P2X7 receptor–pannexin-1 complex decreases muscarinic acetylcholine receptor–mediated seizure susceptibility in mice

(2011) Ji-Eun Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation

(2011) Y. Qu et al.   JOURNAL OF IMMUNOLOGY

Extracellular ATP differentially modulates Toll-like receptor 4-mediated cell survival and death of microglia

(2011) Kana Harada et al.   JOURNAL OF NEUROCHEMISTRY

Targeting Pannexin1 Improves Seizure Outcome

(2011) Marcelo F. Santiago et al.   PLoS One

Pannexins in ischemia-induced neurodegeneration

(2011) P. Bargiotas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alanine substitution scanning of pannexin1 reveals amino acid residues mediating ATP sensitivity

(2011) Feng Qiu et al.   Purinergic Signalling

Erythrocytes as controllers of perfusion distribution in the microvasculature of skeletal muscle

(2010) R. S. Sprague et al.   Acta Physiologica

Pathways for ATP release by bovine ciliary epithelial cells, the initial step in purinergic regulation of aqueous humor inflow

(2010) Ang Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes

(2010) Meera Sridharan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Extracellular ATP Is a Danger Signal Activating P2X7Receptor in Lung Inflammation and Fibrosis

(2010) Nicolas Riteau et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse

(2010) T. Woehrle et al.   BLOOD

Pannexin1 and Pannexin3 Delivery, Cell Surface Dynamics, and Cytoskeletal Interactions

(2010) Ruchi Bhalla-Gehi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pannexin1 and Pannexin2 Channels Show Quaternary Similarities to Connexons and Different Oligomerization Numbers from Each Other

(2010) Cinzia Ambrosi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clearance of apoptotic cells: implications in health and disease

(2010) Michael R. Elliott et al.   JOURNAL OF CELL BIOLOGY

SCAM analysis of Panx1 suggests a peculiar pore structure

(2010) Junjie Wang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors

(2010) Tobias Woehrle et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Metabolic Autocrine Regulation of Neurons Involves Cooperation among Pannexin Hemichannels, Adenosine Receptors, and KATP Channels

(2010) M. Kawamura et al.   JOURNAL OF NEUROSCIENCE

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

Functional significance of the negative-feedback regulation of ATP release via pannexin-1 hemichannels under ischemic stress in astrocytes

(2010) Sadahiro Iwabuchi et al.   NEUROCHEMISTRY INTERNATIONAL

Misregulated E-Cadherin Expression Associated with an Aggressive Brain Tumor Phenotype

(2010) Laura J. Lewis-Tuffin et al.   PLoS One

Purinergic Signaling: A Fundamental Mechanism in Neutrophil Activation

(2010) Y. Chen et al.   Science Signaling

Pannexin 1 Contributes to ATP Release in Airway Epithelia

(2009) George A. Ransford et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pannexins, distant relatives of the connexin family with specific cellular functions?

(2009) Catheleyne D'hondt et al.   BIOESSAYS

ATP Released by Electrical Stimuli Elicits Calcium Transients and Gene Expression in Skeletal Muscle

(2009) Sonja Buvinic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

(2009) William R. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P2X1 Ion Channels Promote Neutrophil Chemotaxis through Rho Kinase Activation

(2009) C. Lecut et al.   JOURNAL OF IMMUNOLOGY

Pannexin 1: The Molecular Substrate of Astrocyte "Hemichannels"

(2009) R. Iglesias et al.   JOURNAL OF NEUROSCIENCE

Autocrine and Paracrine Roles for ATP and Serotonin in Mouse Taste Buds

(2009) Y. A. Huang et al.   JOURNAL OF NEUROSCIENCE

Cell-to-cell communication in intact taste buds through ATP signalling from pannexin 1 gap junction hemichannels

(2009) Robin Dando et al.   JOURNAL OF PHYSIOLOGY-LONDON

Behavioral Phenotypes of Mice Lacking Purinergic P2X4 Receptors in Acute and Chronic Pain Assays

(2009) Makoto Tsuda et al.   Molecular Pain

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Non-junction functions of pannexin-1 channels

(2009) Brian A. MacVicar et al.   TRENDS IN NEUROSCIENCES

P2X7 receptor-Pannexin1 complex: pharmacology and signaling

(2008) R. Iglesias et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Probenecid, a gout remedy, inhibits pannexin 1 channels

(2008) William Silverman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP

(2008) Feng Qiu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Supraspinal Glial-Neuronal Interactions Contribute to Descending Pain Facilitation

(2008) F. Wei et al.   JOURNAL OF NEUROSCIENCE

Pharmacological Characterization of Pannexin-1 Currents Expressed in Mammalian Cells

(2008) W. Ma et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear

(2008) F. Anselmi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Pannexin-1 Hemichannels Augments Aberrant Bursting in the Hippocampus

(2008) R. J. Thompson et al.   SCIENCE

Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels

(2008) U. Schenk et al.   Science Signaling

Stimulation of rat erythrocyte P2X7 receptor induces the release of epoxyeicosatrienoic acids

(2007) H Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY