Article
Cell Biology
Filipe A. Monteiro, Rafael M. Miranda, Marta C. Samina, Ana F. Dias, Alexandre A. S. F. Raposo, Patricia Oliveira, Carlos Reguenga, Diogo S. Castro, Deolinda Lima
Summary: The homeobox gene Tlx3 acts as a selector gene in controlling the development of late-born excitatory neurons in the dorsal spinal cord by specifying glutamatergic transmitter fate. Through genomics and validation experiments, it was found that Tlx3 directly activates genes specific to excitatory neurons and also directly represses genes associated with inhibitory neuronal fate. This study provides insight into the regulatory role of Tlx3 in neural development and reveals its novel function in controlling cell identity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Mira T. Kronschlaeger, Anna S. M. Siegert, Felix J. Resch, Pradeep S. Rajendran, Baljit S. Khakh, Juergen Sandkuehler
Summary: Astrocytes in the dorsal horn of the spinal cord show fine-tuned differences across different layers to meet the demands of processing sensory information of varying modalities. While astrocytes in laminae I and II exhibit higher density and elevated expression levels of certain markers compared to those in lamina III, they share similar membrane properties, network formation, and intracellular calcium signaling characteristics.
Article
Neurosciences
Laura Medlock, Kazutaka Sekiguchi, Sungho Hong, Salvador Dura-Bernal, William W. Lytton, Steven A. Prescott
Summary: Pain-related sensory input is processed in the spinal dorsal horn (SDH) before being relayed to the brain, influencing how stimuli are perceived as painful. Researchers developed a computational model constrained by experimental data to explore SDH function, which reproduced characteristic firing patterns of spinal neurons and responded consistently to inhibition reduction and specific neuron type ablation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Kwan Yeop Lee, Dongchul Lee, Zachary B. Kagan, Dong Wang, Kerry Bradley
Summary: The study found that low-intensity 10 kHz SCS can inhibit pain-sensory processing in the spinal DH by activating inhibitory interneurons, resulting in paresthesia-free pain relief.
Article
Neurosciences
Steve J. Sullivan, Andrei D. Sdrulla
Summary: Excitatory and inhibitory neurons in the superficial dorsal horn (SDH) of the spinal cord diverge considerably in their somatosensory responses and plasticity.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Hanns Ulrich Zeilhofer, Karolina Werynska, Jacinthe Gingras, Gonzalo E. Yevenes
Summary: Restoring proper synaptic inhibition in the spinal cord, particularly through targeting the alpha 3 subtype of glycine receptors, may help reduce deleterious side effects and increase tolerability in chronic pain states. This review provides an update on the physiological properties and functions of alpha 3 subtype GlyRs and related drug discovery programs.
Article
Neurosciences
Eric Brown, Ayma F. Malik, Elizabeth R. Moese, Abigail F. McElroy, Angelo C. Lepore
Summary: Neuropathic pain (NP) is a common and debilitating comorbidity of spinal cord injury (SCI). This study investigates the neural activity changes in the pain circuitry following cervical spinal cord injury. The findings reveal complex changes in neuronal activation, with increased activation in some neurons and decreased activation in inhibitory neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Tyler S. Nelson, Ghanshyam P. Sinha, Diogo F. S. Santos, Peter Jukkola, Pranav Prasoon, Michelle K. Winter, Ken E. McCarson, Bret N. Smith, Bradley K. Taylor
Summary: Peripheral nerve injury enhances the excitability of Y1-INs in the spinal cord dorsal horn, leading to the development of allodynia and affective pain. Inhibition of Y1-INs or administration of Y1 agonists can alleviate allodynic symptoms. Conditional deletion of Npy1r in dorsal horn neurons prevents the anti-hyperalgesic effects of intrathecal Y1 agonists. These findings suggest that Y1-INs in the spinal cord are a promising target for the treatment of neuropathic pain.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Kwan Yeop Lee, Dongchul Lee, Dong Wang, Zachary B. Kagan, Kerry Bradley
Summary: This study found that simultaneously applying 10 kHz SCS caudally and 40 Hz SCS rostrally may provide greater pain relief than either type of SCS alone. This is because simultaneous stimulation increases the firing rates of inhibitory interneurons, although it also leads to greater activation of excitatory interneurons.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Matthew J. Sykes, Orsolya S. Kekesi, Yan T. Wong, Fei-Yue Zhao, David Spanswick, Wendy L. Imlach
Summary: Acetylcholine plays a crucial role in regulating excitatory and inhibitory synaptic activity in neurons within the spinal dorsal horn. Specific responses to ACh induction in rat and marmoset lamina II neurons show consistent cell-type specific reactions, highlighting the importance of cholinergic signaling in nociception modulation across species.
Article
Cell Biology
Tadayuki Ishibashi, Daichi Sueto, Yu Yoshikawa, Keisuke Koga, Ken Yamaura, Makoto Tsuda
Summary: This study identified an inhibitory interneuron subset in the spinal dorsal horn that is depolarized by noradrenaline (NA) and showed that alpha(1B)-adrenoceptors (ARs) and AAV-NpyP(+) neurons are critical targets for spinal NA and necessary for the therapeutic effect of duloxetine on neuropathic pain.
Article
Toxicology
Masatake Fujimura, Fusako Usuki, Atsushi Nakamura
Summary: The study revealed that MeHg exposure caused neurological damage in rats, leading to neuropathic pain, mainly through the activation of microglia in the dorsal horn. Furthermore, analysis of the cerebral cortex showed that MeHg exposure could result in the formation of new cortical circuits in specific areas, leading to hyperalgesia/allodynia.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Wanru Duan, Qian Huang, Fei Yang, Shao-Qiu He, Yun Guan
Summary: This study found that both conventional SCS and 1200 Hz, low-intensity SCS modestly attenuated below-level mechanical hypersensitivity in SCI rats. However, the inhibition of WDR neurons by conventional SCS was not associated with pain inhibition.
Review
Clinical Neurology
Hemant Kumar, Ankita Bhagwani, Manjeet Chopra
Summary: Traumatic spinal cord injury can result in long-lasting complications such as chronic neuropathic pain and spasticity, which significantly impact the daily activities of patients. Current medical treatments for SCI-related neuropathic pain are limited due to the complex mechanisms involved, but restoring inhibitory GABAergic tone and preventing excitotoxicity may provide neuroprotective and analgesic effects.
Article
Multidisciplinary Sciences
Rebecca Rani Das Gupta, Louis Scheurer, Pawel Pelczar, Hendrik Wildner, Hanns Ulrich Zeilhofer
Summary: The study revealed that excitatory and inhibitory neurons in the spinal dorsal horn are not only distinguished by gene expression, but also show differential engagement in neuromodulator pathways, especially neuropeptides.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Erika Elizabeth Rodriguez-Torres, Ulises Paredes-Hernandez, Enrique Vazquez-Mendoza, Margarita Tetlalmatzi-Montiel, Consuelo Morgado-Valle, Luis Beltran-Parrazal, Rafael Villarroel-Flores
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Physiology
Erika E. Rodriguez-Torres, Jorge Viveros-Rogel, Kenia Lopez-Garcia, Enrique Vazquez-Mendoza, Gonzalo Chavez-Fragoso, Salvador Quiroz-Gonzalez, Ismael Jimenez-Estrada
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Mathematics, Interdisciplinary Applications
Diana J. Templos-Hernandez, Luis A. Quezada-Tellez, Brian M. Gonzalez-Hernandez, Gerardo Rojas-Vite, Jose E. Pineda-Sanchez, Guillermo Fernandez-Anaya, Erika E. Rodriguez-Torres
Summary: Fractional dynamics has been incorporated into a nonlinear model to study cardiac behavior, where close to normal heart rhythms have fractional orders close to 1. Fearful individuals and hypertensive participants show different patterns of incorporating fractional dynamics into oscillators. The proposed model can simulate ECG waveforms under various physiological conditions in the human heart, making it potentially applicable in clinical practice.
CHAOS SOLITONS & FRACTALS
(2021)
Article
Urban Studies
R. Molina-Torres, O. Nolasco-Jauregui, E. E. Rodriguez-Torres, B. A. Itza-Ortiz, L. A. Quezada-Tellez
Summary: The pandemic caused by the SARS-CoV-2 virus spreads rapidly in densely populated areas, with millions of confirmed cases in countries like USA, Brazil, and Mexico. These countries also have the highest cumulative death tolls from the disease. A study conducted a comparative analysis of urban development, economic level, and COVID-19 cases in Mexico City, finding a correlation between confirmed cases and factors such as population density, per capita income, and dwelling occupancy index in different municipalities.
JOURNAL OF URBAN MANAGEMENT
(2021)
Article
Physics, Multidisciplinary
Gerardo Rojas-Vite, Valeria Garcia-Munoz, Erika E. Rodriguez-Torres, Erik L. Mateos-Salgado
Summary: Research shows that hypertensive patients have reduced heart rate variability and increased cardiac dynamic recurrence. The hypertensive group lost chaotic behavior, while the normotensive group maintained chaotic nature.
EUROPEAN PHYSICAL JOURNAL-SPECIAL TOPICS
(2022)
Article
Medicine, General & Internal
Rosa Isela Barrera-Cortes, Erika Elizabeth Rodriguez-Torres, Enrique Vazquez-Mendoza, Jesus Carlos Ruvalcaba-Ledezma, Luis Enrique Soria-Jasso, Mario Isidoro Ortiz, Eduardo Fernandez-Martinez
Summary: The liver cancer rates in Hidalgo, Mexico is rising, correlated with alcoholism. The projected increase in liver cancer deaths in 2030 is significant, with females and those over 60 being more affected. Some regions have liver cancer death rates twice the national average or higher.
SAO PAULO MEDICAL JOURNAL
(2022)
Article
Developmental Biology
Vladimir Martinez-Alvarez, Bertha Segura-Alegria, Erika Elizabeth Rodriguez-Torres, Mercedes Graciela Porras, Elsa Aguirre-Benitez, Margarita Gonzalez del Pliego, Robyn Hudson, Salvador Quiroz-Gonzalez, Angel Melo, Ismael Jimenez-Estrada
Summary: The study found that interactions between mothers and siblings during the preweaning period have an impact on the histological and electrophysiological characteristics of the sensory sural nerve (SUn) in adult rats. Rats from litters with more siblings showed greater body weight at postnatal day 60 (PND60), and those from larger litters received fewer maternal licks. Rats from litters with 6 or 9 pups had greater compound action potential (CAP) amplitude and thicker myelin in the SUn compared to rats from litters with 1, 3, or 12 pups.
DEVELOPMENTAL PSYCHOBIOLOGY
(2022)
Article
Neurosciences
Alejandra Rosales-Lagarde, Lourdes Cubero-Rego, Federico Menendez-Conde, Erika E. Rodriguez-Torres, Benjamin Itza-Ortiz, Claudia Martinez-Alcala, Enesis Vaquez-Tagle, Enrique Vazquez-Mendoza, Marta L. Erana Diaz
Summary: Sleep disruption is associated with cognitive impairment and the development of Alzheimer's disease. This study investigated the relationship between cognitive impairment non-dementia (CIND) and arousal indices (AIs) during different sleep stages. The results suggest that in CIND older adults, there is an attenuation of normal arousal mechanisms in REM sleep, possibly related to early pathological damage in the locus coeruleus noradrenergic system present in the Alzheimer's disease continuum.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Social Sciences, Interdisciplinary
Margarita Tetlalmatzi Montiel, Erika Elizabeth Rodriguez Torres, Rafael Villarroel Flores
Meeting Abstract
Clinical Neurology
Erika E. Rodriguez-Torres, Felipe Contreras-Alcala, Pedro Miramontes, Benjamin Itza-Ortiz, Luis A. Quezada-Tellez, C. I. Martinez-Alcala, J. C. Enciso-Alva, V. Garcia-Munoz, Genesis Vazquez-Tagle, Alejandra Rosales-Lagarde
Meeting Abstract
Clinical Neurology
Alejandra Rosales-Lagarde, Erika Elizabeth Rodriguez-Torres, Felipe Contreras-Alcala, Pedro Miramontes, Benjamin Itza-Ortiz, Luis Alberto Quezada-Tellez, Claudia Isabel Martinez-Alcala, Julio Enciso-Alva
Article
Health Care Sciences & Services
Claudia I. Martinez-Alcala, Alejandra Rosales-Lagarde, Esmeralda Hernandez-Alonso, Roberto Melchor-Agustin, Erika E. Rodriguez-Torres, Benjamin A. Itza-Ortiz
JMIR RESEARCH PROTOCOLS
(2018)
Article
Psychology, Multidisciplinary
Alejandra Rosales-Lagarde, Erika E. Rodriguez-Torres, Benjamin A. Itza-Ortiz, Pedro Miramontes, Genesis Vazquez-Tagle, Julio C. Enciso-Alva, Valeria Garcia-Munoz, Lourdes Cubero-Rego, Jose E. Pineda-Sanchez, Claudia Martinez-Alcala, Jose S. Lopez-Noguerola
FRONTIERS IN PSYCHOLOGY
(2018)
Article
Neurosciences
Carlos Escobar-Corona, Sergio Torres-Castillo, Erika Elizabeth Rodriguez-Torres, Bertha Segura-Alegria, Ismael Jimenez-Estrada, Salvador Quiroz-Gonzalez
BRAIN RESEARCH BULLETIN
(2017)
Article
Cell Biology
Enrique Vazquez-Mendoza, Erika Elizabeth Rodriguez-Torres, Kenia Lopez-Garcia, Cindy Xilonen Hinojosa-Rodriguez, Ismael Jimenez-Estrada