Article
Pharmacology & Pharmacy
Hao Wang, Di Ma, Xiaojuan Zhu, Panyue Liu, Shuai Li, Bo Yu, Hong Yang
Summary: Nimodipine effectively inhibits TMEM16A/CaCCs by reducing transmembrane Ca2+ influx and interacting directly with TMEM16A, explaining its relaxing effects on intestinal and aortic smooth muscle contraction.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
M. B. Hawn, E. Akin, H. C. Hartzell, I. A. Greenwood, N. Leblanc
Summary: This article summarizes the functions and regulatory mechanisms of Ca2+-activated Cl- channels, focusing on recent studies on ANO1 and its regulation by internal Ca2+, membrane lipids, and protein partners. It also reviews the basic properties, historical controversies, and molecular structures of CaCCs.
Article
Cardiac & Cardiovascular Systems
Mani Sadredini, Marie Haugsten Hansen, Michael Frisk, William E. Louch, Stephan E. Lehnart, Ivar Sjaastad, Mathis Korseberg Stokke
Summary: Inhibition of CaMKII effectively reduces spontaneous Ca2+ release but promotes Ca2+ alternans in RyR2-R2474S cardiomyocytes with a gain-of-function RyR2 mutation. This increased propensity for Ca2+ alternans is explained by prolongation of Ca2+ release refractoriness, although it does not surpass that of wild type.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Lei Yang, Rong-Chang Li, Bin Xiang, Yi-Chen Li, Li-Peng Wang, Yun-Bo Guo, Jing-Hui Liang, Xiao-Ting Wang, Tingting Hou, Xin Xing, Zeng-Quan Zhou, Haihong Ye, Ren-Qing Feng, Edward G. Lakatta, Zhen Chai, Shi-Qiang Wang
Summary: The contraction of heart cells is regulated by the signaling interaction between LCCs and RyRs, which is influenced by the nanodistance between JPH2 in the SR and CAV3 in the TT. Our study revealed that SRF and myocardin concurrently regulate the expression of JPH2 and CAV3, leading to enhanced efficiency of LCC-RyR signaling and compensation for LCC down-regulation during hibernation, maintaining heart power and avoiding calcium overload.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Chemical
Yuhei Ogura, Hiroaki Ito, Shukei Sugita, Masanori Nakamura, Yoshihiro Ujihara
Summary: Mammals and birds have faster heart rates, and birds achieve fast Ca2+ concentration changes by increasing the Ca2+ removal capacity in the central part of the cardiomyocytes.
Review
Multidisciplinary Sciences
Weiliang Bai, Mei Liu, Qinghuan Xiao
Summary: TMEM16A is a calcium-activated chloride channel protein that plays diverse roles in inflammation, including promoting the release of inflammatory mediators, increasing vascular permeability, and sensing pain. In different inflammatory diseases, TMEM16A exerts varied pathological effects in a cellular environment-dependent manner.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Dmitrii Kolesnikov, Anastasiia Perevoznikova, Konstantin Gusev, Lyubov Glushankova, Elena Kaznacheyeva, Alexey Shalygin
Summary: Local calcium entry through TRPC1 channels activates endogenous calcium-activated chloride channels (CaCCs), suggesting their involvement in calcium entry microdomains. The properties of CaCCs are influenced by transmembrane potential and calcium concentration, with close local arrangement of functional CaCCs and TRPC1 channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Arlene Martinez-Rivera, Jin Hao, Richard Rice, Charles E. Inturrisi, Anjali M. Rajadhyaksha
Summary: In this study, the researchers demonstrated that Cav1.3 channels in the ventral tegmental area (VTA) are required for cocaine reward behavior. They also found that the CaMKII alpha/ERK/CREB signaling pathway in the VTA is necessary for long-lasting changes in the nucleus accumbens (NAc) following cocaine conditioned place preference (CPP).
Article
Cell Biology
Kateryna Demydenko, Karin R. Sipido, H. Llewelyn Roderick
Summary: The study revealed that InsP3Rs influence Ca2+ handling during ECC by enhancing dyadic Ca2+ fluxes and increasing Ca2+ sparks, which facilitate the activation of RyRs. This mechanism contributes to neurohormonal modulation of cardiac function.
JOURNAL OF CELL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Sarah L. Sturgill, Lorien G. Salyer, Brandon J. Biesiadecki, Mark T. Ziolo
Summary: High-quality cardiomyocytes are essential for research in cardiac biology. The previously used methods requiring high levels of training and precision have been replaced with simpler and more reliable techniques.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Editorial Material
Urology & Nephrology
Normand Leblanc
Summary: Hypertension is a major risk factor for heart disease and stroke, and the novel molecule TMinh-23 shows potential as an effective treatment for hypertension.
KIDNEY INTERNATIONAL
(2021)
Review
Physiology
Bernard T. Drumm, Keith D. Thornbury, Mark A. Hollywood, Gerard P. Sergeant
Summary: Urinary continence is maintained by the contracture of urethral sphincters, including the role of Ano1 channels expressed in urethral ICC in increasing smooth muscle excitability. However, the specific role of urethral Ano1 channels remains unclear due to differences in species and experimental approaches. Clarifying this situation is crucial for developing new treatments for urinary incontinence.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Cell Biology
Chengwen Hang, Yuanxiu Song, Ya'nan Li, Siyao Zhang, Yun Chang, Rui Bai, Amina Saleem, Mengqi Jiang, Wenjing Lu, Feng Lan, Ming Cui
Summary: Myomesin-1, encoded by MYOM1 gene, plays a crucial role in sarcomere assembly and cardiomyocyte development, but its biological function in MYOM1-related myopathies, especially in the heart, is not well understood. The establishment of an MYOM1 knockout human embryonic stem cell line provides a useful model for studying the role of myomesin-1 and investigating the pathogenesis and potential treatments of myocardial atrophy caused by myomesin-1 deficiency.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Woori Ko, Byung-Chang Suh
Summary: The membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P-2) selectively modulates the gating of the TMEM16A(ac) channel in an agonistic manner, leading to the upregulation of TMEM16A(ac) functions in physiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Tianyu Wang, Hui Wang, Fan Yang, Kuan Gao, Shuya Luo, Lichuan Bai, Ke Ma, Mei Liu, Shuwei Wu, Huijie Wang, Zaixing Chen, Qinghuan Xiao
Summary: This study revealed a new anticancer mechanism of honokiol by inhibiting cell proliferation through targeting Ano1 Ca2+-activated Cl- channels. Honokiol more potently inhibited Ano1 currents compared to Ano2 currents, with three critical amino acids (R429, K430, and N435) identified for honokiol-induced Ano1 inhibition.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jaimie D. Nathan, Kate Ellery, Keshawadhana Balakrishnan, Heli Bhatt, Armando Ganoza, Sohail Z. Husain, Rakesh Kumar, Veronique D. Morinville, J. Antonio Quiros, Sarah J. Schwarzenberg, Zachary M. Sellers, Aliye Uc, Maisam Abu-El-Haija
Summary: Chronic pancreatitis is rare but impactful in childhood, and surgical management must be tailored to the patient's unique needs, considering the morphology of the disease and presence of genetic risk factors. Total pancreatectomy with islet autotransplantation is the best surgical option for patients with small duct disease.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Chinenye R. Dike, Zachary M. Sellers, Sohail Z. Husain, Christopher E. Forsmark, Maisam Abu-El-Haija
Summary: This article aims to provide guidance on the personnel (both physician and nonphysician) needed to provide care for children with pancreatitis, as well as potential alternatives. Further research is needed to understand the impact of these personnel on children with pancreatitis.
Review
Gastroenterology & Hepatology
Madhura Y. Phadke, Zachary M. Sellers
Summary: Pancreatitis risk is associated with CFTR dysfunction and new therapeutic advancements targeting CFTR provide opportunities for treatment relief in CFTR-related pancreatitis.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Genetics & Heredity
Sriram Vaidyanathan, Annie M. Trumbull, Lilly Bar, Manaeha Rao, Yunnan Yu, Zachary M. Sellers
Summary: This study aimed to characterize cystic fibrosis (CF) in Asian subgroups and found a higher prevalence of CF in South Asians and significant differences in CFTR variants between Asians and non-Hispanic Whites. These disparities contribute to inequities in newborn screening, diagnosis, and treatment.
GENETICS IN MEDICINE
(2022)
Letter
Pediatrics
Patrick T. Reeves, William C. Bennett, Michael Y. McCown, Sebastian K. Welsh, Catherine M. McDonald, Leila Beker, Sandra Robbins, David S. Vitale, Christopher Siracusa, Jefferson N. Brownell, Zachary M. Sellers, Sofia Echelmeyer, Jeffrey Livezey, Danielle M. Barnes
PEDIATRIC PULMONOLOGY
(2022)
Article
Gastroenterology & Hepatology
Aliye Uc, Gretchen A. Cress, Fuchenchu Wang, Maisam Abu-El-Haija, Kate M. Ellery, Douglas S. Fishman, Cheryl E. Gariepy, Tanja Gonska, Tom K. Lin, Quin Y. Liu, Megha Mehta, Asim Maqbool, Brian A. McFerron, Veronique D. Morinville, Chee Y. Ooi, Emily R. Perito, Sarah Jane Schwarzenberg, Zachary M. Sellers, Jose Serrano, Uzma Shah, David M. Troendle, Michael Wilschanski, Yuhua Zheng, Ying Yuan, Mark E. Lowe
Summary: This study investigates the risk factors and disease burden in pediatric acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). Findings suggest that CP is more commonly associated with female sex, younger age at first AP attack, Asian race, family history of CP, lower BMI%, genetic and obstructive factors, PRSS1 mutations and pancreas divisum. CFTR mutations, toxic-metabolic factors, medication use, hypertriglyceridemia, Crohn disease were more common in children with ARP. CP is associated with more severe symptoms and treatments, while ARP is characterized by episodic pain.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Respiratory System
Dhiren Patel, Stacy Mathews, Vincent van Unen, Joshua E. Chan, Noor Al-Hammadi, Drucy Borowitz, Daniel Gelfond, Zachary M. Sellers
Summary: Previous studies on wireless motility capsule (WMC) have shown decreased small intestinal pH in people with cystic fibrosis (CF), but data on colonic pH profile is lacking. In this study, the re-analysis of WMC data revealed significantly lower pH and bicarbonate concentration values in CF patients, especially in the distal rectosigmoid region. However, there was no difference in colonic motility parameters between CF and non-CF subjects. The abundantly expressed bicarbonate transporter SLC26A3 in the human colon and rectum may serve as a therapeutic target for restoring bicarbonate transport and better understanding gastrointestinal symptoms in CF patients.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Physiology
Eszter K. Vladar, Koshi Kunimoto, Laura S. Rojas-Hernandez, Jacquelyn M. Spano, Zachary M. Sellers, Nam Soo Joo, Riley A. Cooney, Jeffrey D. Axelrod, Carlos E. Milla
Summary: Loss of multiciliated cells is a common characteristic in chronic inflammatory airway diseases. Notch signaling plays a crucial role in controlling the proportion of multiciliated and secretory cells. Inhibition of Notch activation using a small molecule inhibitor can promote differentiation towards the multiciliated lineage. LY450139, a specific ?-secretase inhibitor, has shown potential in increasing multiciliated cell numbers without toxicity in both healthy and diseased lung cells, suggesting it as a promising therapeutic option to restore multiciliated cells and improve epithelial function in chronic lung diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Veronique D. Morinville, Sohail Z. Husain, Fuchenchu Wang, Gretchen A. Cress, Maisam Abu-El-Haija, Ankur Chugh, Elissa Downs, Kate Ellery, Douglas S. Fishman, Alvin Jay Freeman, Cheryl E. Gariepy, Matthew Giefer, Tanja Gonska, Quin Liu, Asim Maqbool, Jacob Mark, Brian Arthur Mcferron, Megha Mehta, Jaimie D. Nathan, Ken Ng, Chee Y. Ooi, Emily Perito, Wenly Ruan, Sarah Jane Schwarzenberg, Zachary M. Sellers, Jose Serrano, David M. Troendle, Michael Wilschanski, Yuhua Zheng, Ying Yuan, Mark Lowe, Aliye Uc
Summary: This study aimed to analyze the characteristics, co-risk factors, and reliability of the Naranjo scoring system for drug-associated acute pancreatitis (DAP) in children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). The results showed that medications were involved in 7% of ARP or CP patients in the INSPPIRE-2 cohort, with most patients having other risk factors for pancreatitis. The Naranjo scoring system raised questions about its reliability for DAP.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Maisam Abu-El-Haija, Lindsey Hornung, Kate Ellery, Douglas S. Fishman, Tanja Y. Gonska, Cheryl Gariepy, Mark Lowe, Katie Larson Ode, Asim Maqbool, Maria Mascarenhas, Veronique D. Morinville, Chee Y. Ooi, Emily R. Perito, Sarah Jane Schwarzenberg, Zachary M. Sellers, Babette S. Zemel, Ying Yuan, Fuchenchu Wang, Aliye Uc, Heidi J. Kalkwarf
Summary: Children with acute recurrent pancreatitis and chronic pancreatitis have lower height and bone mineral density compared to healthy peers, calling for attention to deficits in growth and bone mineral accrual.
Article
Gastroenterology & Hepatology
Steven Levitte, Yonathan Fuchs, Russell Wise, Zachary M. Sellers
Summary: This study retrospectively analyzed the changes in liver function and fibrosis indices in children with cystic fibrosis (CF) treated with lumacaftor/ivacaftor and elexacaftor/tezacaftor/ivacaftor. The results suggest that lumacaftor/ivacaftor may improve liver fibrosis in children with CF and be beneficial in the treatment of CF-associated liver disease.
HEPATOLOGY COMMUNICATIONS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Annie M. Trumbull, Shayda Abazari, Jessica B. Sarthi, Vincent van Unen, Joshua E. Chan, Calvin Kuo, Zachary M. Sellers
Meeting Abstract
Gastroenterology & Hepatology
Michael Wilschanski, Mordechai Slae, Maisam Abu-El-Haija, Elvi Sanjines, Zachary M. Sellers
Meeting Abstract
Gastroenterology & Hepatology
Veronique D. Morinville, Sohail Z. Husain, Fuchenchu Wang, Gretchen A. Cress, Maisam Abu-El-Haija, Elissa Downs, Kate Ellery, Douglas S. Fishman, Cheryl E. Gariepy, Praveen S. Goday, Tanja Gonska, Quin Liu, Asim Maqbool, Jacob Mark, Brian A. Mcferron, Chee Y. Ooi, Emily Perito, Sarah Jane Schwarzenberg, Zachary M. Sellers, Uzma Shah, David M. Troendle, Michael Wilschanski, Yuhua Zheng, Ying Yuan, Mark Lowe, U. C. Aliye
Meeting Abstract
Gastroenterology & Hepatology
Alvin J. Freeman, Kenneth Ng, Fuchenchu Wang, Gretchen A. Cress, Maisam Abu-El-Haija, Kate Ellery, Douglas S. Fishman, Cheryl E. Gariepy, Praveen S. Goday, Tanja Gonska, Tom K. Lin, Quin Liu, Asim Maqbool, Brian A. Mcferron, Veronique D. Morinville, Chee Y. Ooi, Emily Perito, Sarah Jane Schwarzenberg, Zachary M. Sellers, Uzma Shah, David M. Troendle, Michael Wilschanski, Yuhua Zheng, Ying Yuan, Mark Lowe, Aliye Uc