Article
Multidisciplinary Sciences
Liza J. Severs, Nicholas E. Bush, Lely A. Quina, Skyler Hidalgo-Andrade, Nicholas J. Burgraff, Tatiana Dashevskiy, Andy Y. Shih, Nathan A. Baertsch, Jan-Marino Ramirez
Summary: Sighs play important roles in lung function, emotional expression and arousal. The preBotzinger complex (preBotC) is involved in the generation of spontaneous and hypoxia-induced sighs. Purinergic signaling is necessary for the generation of sighs and increasing astrocytic calcium levels can enhance sigh frequency.
NATURE COMMUNICATIONS
(2023)
Review
Biology
Lorenzo Donald, Edward G. Lakatta
Summary: Cardiovascular science has been studying the heartbeat even before the discovery of the sinoatrial node. The field became divided between electrophysiology and muscle contraction but was later reunited by the coupled-clock theory of pacemaker cell function. Recent discoveries have contextualized this theory into the complex world of sinoatrial node tissue, conceptualizing it as a brain-like structure composed of various types of cells and networks.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Biology
Jakub Tomek, Manuela Zaccolo
Summary: In the past 30 years, the understanding of cyclic adenosine 3',5'-monophosphate (cAMP) signaling has changed from a linear pathway to a complex network, where spatial regulation of cAMP plays a critical role. This new model provides novel insights into cardiac myocyte physiology and provides a framework for identifying disease mechanisms, particularly in the regulation of cardiac rhythm.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Neurosciences
Andrew Sheriff, Guinevere Pandolfi, Vivian S. Nguyen, Leslie M. Kay
Summary: The study reveals widespread interactions among nasal respiration, olfactory bulb, piriform cortex, and hippocampus in awake freely moving rats, supporting the piriform cortex as an integrator of respiratory and theta activity.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemical Research Methods
Gang Wu, Marc D. Ruben, Lauren J. Francey, Yin Yeng Lee, Ron C. Anafi, John B. Hogenesch
Summary: In this study, we developed a new computational approach called LTM to explore candidate pathways coupled to the clock in human tissues. The cell cycle was identified as the top candidate clock-coupled pathway in healthy skin, while extracellular matrix organization-related pathways were tightly associated with clock strength in tumor samples.
Article
Neurosciences
Nicholas J. Burgraff, Nicholas E. Bush, Jan M. Ramirez, Nathan A. Baertsch
Summary: Death from opioid overdose is often caused by opioid-induced respiratory depression, which is characterized by its unpredictability. Studies have shown that the preBotzinger complex in the ventral medulla plays a crucial role in respiratory rhythm and OIRD, as it can assume different network states based on excitability and intrinsic properties of neurons. These network states can predict the effects of opioids on respiratory rhythmogenesis, either stabilizing or suppressing it based on the network state.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Computer Science, Information Systems
Shuxun Zan, Yujie Zhang, Xiangwu Meng, Pengtao Lv, Yulu Du
Summary: Group recommendation systems have gained significant research attention in recent years, with the focus on learning the weights of group members and aggregating their preferences. This study emphasizes the importance of comparison information and proposes a user-difference attention model to explicitly simulate comparisons between group members.
INFORMATION SCIENCES
(2021)
Article
Psychology, Biological
Beate Rassler, Andreas Schwerdtfeger, Gerhard Schwarz, Gert Pfurtscheller
Summary: A rare manifestation of respiratory sinus arrhythmia called negative RSA was found in healthy individuals during elevated anxiety, indicating a possible relationship between nRSA and anxiety.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Neurosciences
Josue de Jesus Juarez-Vidales, Jesus Perez-Ortega, Jonathan Julio Lorea-Hernandez, Felipe Mendez-Salcido, Fernando Pena-Ortega
Summary: The study revealed that the pre-Botzinger complex (preBotC) exhibits a scale-free configuration and a rich-club phenomenon, with neurons producing stable multineuronal activity patterns that change during hypoxia, and containing a coactivating core network with a distinctive pattern of coactivation at the beginning of inspirations. These findings provide insights into the network basis of inspiratory rhythm generation and its reconfiguration during hypoxia.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Cell Biology
Carlos A. da Silva Jr, Cameron J. Grover, Maria Cristina D. Picardo, Christopher A. Del Negro
Summary: The Scn8a gene plays a crucial role in respiratory control by regulating the Na+ current, impacting the rhythm generation in respiratory interneurons. However, it does not affect breathing in adult mice. This finding is significant for understanding respiratory development and rhythmic function.
Article
Materials Science, Multidisciplinary
Xinzhi Liu, Yiqun Wang, Guiying Wang, Yifei Ma, Zhihao Zheng, Kuikui Fan, Junchen Liu, Bingqian Zhou, Gan Wang, Zheng You, Yin Fang, Xiaofeng Wang, Simiao Niu
Summary: This study presents a subcutaneously implantable flexible ultrasound energy harvesting system that integrates a TENG transducer and a power management circuit. The system offers higher power output and lower impedance compared to existing work, and it has broad applications and can provide stable DC voltage and sufficient power supply.
Article
Multidisciplinary Sciences
Caroline K. David, Yae K. Sugimura, Prajkta S. Kallurkar, Maria Cristina D. Picardo, Margaret S. Saha, Gregory D. Conradi Smith, Christopher A. Del Negro
Summary: This study utilized whole-cell patch-clamp recordings and single-cell RNA sequencing to characterize the electrophysiological properties and gene expression of neurons involved in inspiratory breathing movements.
Article
Chemistry, Multidisciplinary
Bjarne Kreitz, Patrick Lott, Felix Studt, Andrew J. J. Medford, Olaf Deutschmann, C. Franklin Goldsmith
Summary: The study proposes an ab-initio based framework for automating the construction of microkinetic mechanisms with correlated uncertainties. By generating 2000 unique microkinetic models within the uncertainty space of the BEEF-vdW functional, the oxidation reactions of exhaust gas emissions over Pt(111) were compared to experiments through multiscale modeling. The importance of considering uncertainties is stressed through the ensemble of simulations. A microkinetic mechanism that agrees with experimental data can be identified from the set of first-principles-based models, and it suggests Pt(111) as the active site for the oxidation of light hydrocarbons. The study provides a universal framework for automating the construction of reaction mechanisms with correlated uncertainty quantification and enables DFT-constrained microkinetic model optimization for other catalyzed systems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Physics, Fluids & Plasmas
Wenxin Zheng, Changgui Gu, Huijie Yang, Jos H. T. Rohling
Summary: This article theoretically analyzed the network of the two nuclei of the suprachiasmatic nucleus (SCN) in mammals and its relation to the function of the SCN. The authors found that the integration range is larger in the motifs containing a link between the ventrolateral (VL) parts across the nuclei, but it is smaller in the motifs that contain a link between the dorsomedial (DM) parts across the nuclei. The SCN can strengthen or weaken connections between the left and right nucleus to adapt to changes in external conditions.
Article
Biology
Ryan S. Phillips, Hidehiko Koizumi, Yaroslav Molkov, Jonathan E. Rubin, Jeffrey C. Smith
Summary: This study experimentally confirmed the roles of neuronal persistent sodium current (I-NaP) and calcium-activated non-selective cation current (I-CAN) in the respiratory oscillator. The results showed that I-NaP is essential for rhythm generation, while I-CAN plays a crucial role in determining the amplitude of rhythmic output.
Article
Multidisciplinary Sciences
John A. Hayes, Andrew Kottick, Maria Cristina D. Picardo, Andrew D. Halleran, Ronald D. Smith, Gregory D. Smith, Margaret S. Saha, Christopher A. Del Negro
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
John A. Hayes, Eirini Papagiakoumou, Pierre-Louis Ruffault, Valentina Emiliani, Gilles Fortin
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Article
Neurosciences
Wiktor S. Phillips, Christopher A. Del Negro, Jens C. Rekling
JOURNAL OF NEUROSCIENCE
(2018)
Review
Neurosciences
Christopher A. Del Negro, Gregory D. Funk, Jack L. Feldman
NATURE REVIEWS NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Maria Cristina D. Picardo, Yae K. Sugimura, EKaitlyn Dorst, Prajkta S. Kallurkar, Victoria T. Akins, Xingru Ma, Ryoichi Teruyama, Romain Guinamard, Kaiwen Kam, Margaret S. Saha, Christopher A. Del Negro
Article
Physiology
Ann L. Revill, Alexis Katzell, Christopher A. Del Negro, William K. Milsom, Gregory D. Funk
Summary: Recording KCNQ-like currents in neonatal rat slices with retained respiratory rhythmicity, the study found that blocking KCNQ channels significantly increased inspiratory burst duration, while activation of KCNQ channels decreased it.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Prajkta S. Kallurkar, Maria Cristina D. Picardo, Yae K. Sugimura, Margaret S. Saha, Gregory D. Conradi Smith, Christopher A. Del Negro
Summary: This study investigates whether rhythm- and pattern-generating functions exist in different classes of Dbx1 preBotC neurons. The results reveal that putatively rhythmogenic Type-1 neurons activate before Type-2 neurons and the inspiratory motor output. Transcriptome analysis identified differential expression of genes, including ionotropic receptors and Ca2+ signaling pathways, which may explain their activation profiles and involvement in inspiratory bursts. Surprisingly, neuropeptide receptors that influence breathing were only sparsely expressed in these neuron types.
SCIENTIFIC REPORTS
(2022)
Review
Neurosciences
Sufyan Ashhad, Kaiwen Kam, Christopher A. Del Negro, Jack L. Feldman
Summary: Breathing is a vital behavior that has a broad influence on the brain and body. Recent advances in understanding the neural control system of breathing, called the breathing central pattern generator (bCPG), have revealed its complexity and its connections to emotions and cognition. These findings bring great potential for further research on the function and dysfunction of breathing and other neural circuits in mammals.
ANNUAL REVIEW OF NEUROSCIENCE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Carlos Aparecido, Carlos Aparecido da Silva Junior, Maria Cristina D. Picardo, Christopher A. Del Negro
Article
Multidisciplinary Sciences
Caroline K. David, Yae K. Sugimura, Prajkta S. Kallurkar, Maria Cristina D. Picardo, Margaret S. Saha, Gregory D. Conradi Smith, Christopher A. Del Negro
Summary: This study utilized whole-cell patch-clamp recordings and single-cell RNA sequencing to characterize the electrophysiological properties and gene expression of neurons involved in inspiratory breathing movements.
Article
Cell Biology
Carlos A. da Silva Jr, Cameron J. Grover, Maria Cristina D. Picardo, Christopher A. Del Negro
Summary: The Scn8a gene plays a crucial role in respiratory control by regulating the Na+ current, impacting the rhythm generation in respiratory interneurons. However, it does not affect breathing in adult mice. This finding is significant for understanding respiratory development and rhythmic function.
Article
Neurosciences
Nikolas C. Vann, Francis D. Pham, Kaitlyn E. Dorst, Christopher A. Del Negro
Article
Physiology
Andrew Kottick, Caroline A. Martin, Christopher A. Del Negro
PHYSIOLOGICAL REPORTS
(2017)
Article
Neurosciences
Prajkta S. Kallurkar, Cameron Grover, Maria Cristina D. Picardo, Christopher A. Del Negro
