Review
Neurosciences
Maria Gurma, Yi-Mei Yang, Lu-Yang Wang
Summary: This article reviews the impact of NMDARs on central synapse function during the early postnatal stage and raises unanswered questions that are crucial for understanding the developing brain in health and diseases.
Review
Biochemistry & Molecular Biology
Sofia Beghi, Malgorzata Furmanik, Armand Jaminon, Rogier Veltrop, Nikolas Rapp, Kanin Wichapong, Elham Bidar, Annamaria Buschini, Leon J. Schurgers
Summary: Cardiovascular disease remains a major cause of death worldwide, despite advancements in medication and preventive measures. Calcium plays a vital role in the cardiovascular system, regulating events from action potentials to muscle contraction. Calcium calmodulin pathways are involved in the regulation of cardiac functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Michal Marcinkowski, Tomas Pilzys, Damian Garbicz, Jan Piwowarski, Kaja Przygonska, Maria Winiewska-Szajewska, Karolina Ferenc, Oleksandr Skorobogatov, Jaroslaw Poznanski, Elzbieta Grzesiuk
Summary: FTO is an N-6-methyladenosine demethylase which can remove methyl groups from nucleic acids, forming complexes with other proteins. Research indicates an interaction between FTO and calmodulin (CaM), influencing calcium-binding loops in CaM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Parasitology
Hai-Jun Gao, Xu-Dong Sun, Yan-Ping Luo, Hua-Sheng Pang, Xing-Ming Ma, Ting Zhang, Tao Jing, Wei Hu, Yu-Juan Shen, Jian-Ping Cao
Summary: The study demonstrated that verapamil has anti-parasitic effects against Echinococcus by downregulating the expression of Ca2+/CaM-CaMKII, indicating that Ca2+/CaM-CaMKII may be a novel drug target for the treatment of echinococcosis.
PARASITES & VECTORS
(2021)
Article
Pathology
Ashton N. Jorgensen, Chowdhury S. Abdullah, Md. Shenuarin Bhuiyan, Megan Watt, Paari Dominic, Gopi K. Kolluru, Christopher G. Kevil, Hyung W. Nam
Summary: In this study, we investigated the role of neurogranin (Ng) expression in the heart and its impact on cardiac hypertrophy and fibrosis. Our findings suggest that depletion of Ng leads to dysregulation of Ca2+ homeostasis and promotes cardiac failure in mice.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tayde Quiroz-Acosta, Karina Bermeo, Isabel Arenas, David E. Garcia
Summary: Lipid regulation of ion channels plays a crucial role in physiological processes such as neurotransmitter release and hormone secretion. Ceramide, as a bioactive lipid, is proposed to regulate voltage-gated ion channels, including potassium channels (Kv). In this study, we investigated the regulation of Kv channels by accumulated ceramide in native pancreatic β-cells. Our results suggest that intramembrane ceramide accumulation may alter pancreatic β-cell repolarization and secretion, providing new insights into lipid-protein regulation and the actions of ceramide on Kv channels.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Jerome Anthony E. Alvarez, M. Saleet Jafri, Aman Ullah
Summary: This study developed a stochastic ventricular cardiomyocyte model that can adapt to intracellular calcium dynamics, spark regulation, and frequency-dependent changes. The model demonstrated that calcium release events and ion channel responses are dynamically altered under different stimuli.
Article
Biochemistry & Molecular Biology
Shuhang Dai, Elisa Venturini, Saveg Yadav, Xiaoxuan Lin, Dylan Clapp, Martin Steckiewicz, Angela M. Gocher-Demske, Arthur M. Edelman, D. Grahame Hardie
Summary: This study reveals the important role of CaMKK2 in mediating EGFR signaling in cancer cells, with regulation mechanisms involving both calcium-dependent and calcium-independent pathways. Additionally, CaMKK2 regulates transcription of key genes, impacting cell survival and proliferation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Oanh Tran, Silke Kerruth, Catherine Coates, Hansween Kaur, Camillo Peracchia, Tom Carter, Katalin Torok
Summary: This study investigates the interaction of Ca2+/calmodulin (Ca2+/CaM) with connexins (Cx) and provides insights into the regulation of gap junction function. The CL2 peptides of different Cx isoforms were found to have high affinity for Ca2+/CaM and also bind to apo-CaM. Furthermore, conformational changes in the CL2 domain were observed, suggesting its involvement in the hexameric gap junction. Ca2+/CaM was shown to inhibit gap junction permeability in a dose-dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Tharaka Wijerathne, Wei -Yin Lin, Akila Cooray, Shmuel Muallem, Kyu Pil Lee
Summary: Recent structural studies have found that the carboxyl-terminus of TRP channels, including TRPC3, is folded into a horizontal rib helix connected to a vertical pole helix, which plays a role in interactions and multimerization. By identifying key hydrophobic residues in the pole helix and using mutations, the study determines their role in TRPC3 regulation by Ca2+ and Calmodulin. The findings suggest that the hydrophobic starch formed by these residues modulates TRPC3 gating, channel selectivity, and Ca2+ permeability.
Article
Cell Biology
Wietske E. Tuinte, Eniko Torok, Irene Mahlknecht, Petronel Tuluc, Bernhard E. Flucher, Marta Campiglio
Summary: The adaptor protein STAC3 is essential for the functional expression and excitation-contraction coupling of the skeletal muscle Ca(V)1.1 channel. STAC3 can inhibit the voltage-dependent inactivation (VDI) of Ca(V)1.1 currents but not the calcium-dependent inactivation (CDI). Mutant STAC3-ETLAAA supports Ca(V)1.1 functional expression and EC coupling but accelerates the kinetics of activation and inactivation of Ca(V)1.1 currents. STAC3 is determined to be a crucial determinant for the slow activation kinetics of Ca(V)1.1 currents.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Engineering, Environmental
Wenhui Qiu, Honghong Chen, Shuwen Zhang, Ying Xiong, Ming Zheng, Tingting Zhu, Minkyu Park, Jason T. Magnuson, Chunmiao Zheng, Mohamed Gamal El-Din
Summary: This study explores the mechanisms of calcium peroxide (CaO2) inactivation of pathogen indicators at low concentrations, finding that OH- and center dot OH are the main factors in the inactivation process. Copper ions were found to enhance the inactivation of pathogens by CaO2, while dissolved organic matter had a negative effect.
Article
Multidisciplinary Sciences
Kunitoshi Uchida, Tomo Kita, Mitsutoki Hatta, Satoru G. Itoh, Hisashi Okumura, Makoto Tominaga, Jun Yamazaki
Summary: TRPM5 channel, activated by intracellular Ca2+, plays a role in controlling membrane potentials. Substitution of specific amino acid residues in the pore helix of TRPM5 can affect the time constant of voltage-dependent inactivation.
Article
Cell Biology
Girish Ramesh, Lukas Jarzembowski, Yvonne Schwarz, Vanessa Poth, Maik Konrad, Mona L. Knapp, Gertrud Schwar, Anna A. Lauer, Marcus O. W. Grimm, Dalia Alansary, Dieter Bruns, Barbara A. Niemeyer
Summary: STIM1B, a neuronal-specific splice variant of STIM1, plays a crucial role in regulating neuronal calcium homeostasis and synaptic plasticity by converting synaptic depression into short-term synaptic enhancement.
Article
Cell Biology
Kristen L. Segars, Nicholas A. Azzari, Stephanie Gomez, Cody Machen, Celeste B. Rich, Vickery Trinkaus-Randall
Summary: Research has shown that changes in corneal stiffness and signaling contribute to decreased wound healing efficacy in older mice. As mice age, the stiffness of the cornea changes, leading to longer healing times. Additionally, there is reduced calcium signaling at the wound site in older mice, resulting in lower cell activity compared to younger mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Shoko Hososhima, Hideya Yuasa, Toru Ishizuka, Mohammad Razuanul Hoque, Takayuki Yamashita, Akihiro Yamanaka, Eriko Sugano, Hiroshi Tomita, Hiromu Yawo
SCIENTIFIC REPORTS
(2015)
Article
Biology
Takayuki Yamashita, Carl C. H. Petersen
Article
Neurosciences
Laura Busse, Jessica A. Cardin, M. Eugenia Chiappe, Michael M. Halassa, Matthew J. McGinley, Takayuki Yamashita, Aman B. Saleem
JOURNAL OF NEUROSCIENCE
(2017)
Article
Anatomy & Morphology
Takayuki Yamashita, Angeliki Vavladeli, Aurelie Pala, Katia Galan, Sylvain Crochet, Sara S. A. Petersen, Carl C. H. Petersen
FRONTIERS IN NEUROANATOMY
(2018)
Article
Neurosciences
Hiroyasu Watanabe, Takayuki Yamashita, Naoto Saitoh, Shigeki Kiyonaka, Akihiro Iwamatsu, Kevin P. Campbell, Yasuo Mori, Tomoyuki Takahashi
JOURNAL OF NEUROSCIENCE
(2010)
Article
Neurosciences
Takayuki Yamashita, Takeshi Kanda, Kohgaku Eguchi, Tomoyuki Takahashi
JOURNAL OF PHYSIOLOGY-LONDON
(2009)
Article
Neurosciences
Takayuki Yamashita, Kohgaku Eguchi, Naoto Saitoh, Henrique von Gersdorff, Tomoyuki Takahashi
NATURE NEUROSCIENCE
(2010)
Article
Neurosciences
Takayuki Yamashita, Aurelie Pala, Leticia Pedrido, Yves Kremer, Egbert Welker, Carl C. H. Petersen
Review
Neurosciences
Takayuki Yamashita
NEUROSCIENCE RESEARCH
(2012)
Article
Neurosciences
Han-Ying Wang, Kohgaku Eguchi, Takayuki Yamashita, Tomoyuki Takahashi
JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Takanori Matsubara, Takayuki Yanagida, Noriaki Kawaguchi, Takashi Nakano, Junichiro Yoshimoto, Maiko Sezaki, Hitoshi Takizawa, Satoshi P. Tsunoda, Shin-ichiro Horigane, Shuhei Ueda, Sayaka Takemoto-Kimura, Hideki Kandori, Akihiro Yamanaka, Takayuki Yamashita
Summary: The authors demonstrated the use of inorganic scintillators to remotely control neural functions in living animals through X-ray irradiation. The injectable scintillator microparticles were shown to effectively activate and inhibit midbrain dopamine neurons in freely moving mice, modulating behavior bidirectionally. This study highlights the potential of scintillator-mediated optogenetics for minimally invasive, wireless control of cellular functions at various tissue depths in biological and medical research.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Masahiro Kawatani, William C. de Groat, Keiichi Itoi, Katsuya Uchida, Kenji Sakimura, Akihiro Yamanaka, Takayuki Yamashita, Masahito Kawatani
Summary: Research shows that Barrington's nucleus (Bar) forms strong glutamatergic monosynaptic connections with lumbosacral preganglionic neurons (LS-PGNs), while BarESR1 neurons also elicit smaller-amplitude glutamatergic polysynaptic or inhibitory postsynaptic currents in some LS-PGNs. Optogenetic stimulation of BarCRH and BarESR1 terminals elicits both excitatory and inhibitory responses in sacral dorsal commissural nucleus (DCN) neurons, including interneurons projecting to the IML or ventral horn. The integration of inputs from Bar to autonomic circuitry in the lumbosacral spinal cord may play a role in controlling micturition behavior.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Takanori Matsubara, Takayuki Yamashita
Summary: Traditional optogenetics is invasive, but recent advancements in material science and neuroscience have enabled remote optogenetic control. These new technologies have stimulated researchers to test novel strategies for less invasive, wireless control of cellular functions in the brain and other tissues.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Neurosciences
Takayuki Yamashita, Akihiro Yamanaka
CURRENT OPINION IN NEUROBIOLOGY
(2017)