Journal
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
Volume 67, Issue 1, Pages 35-42Publisher
SPRINGER
DOI: 10.1007/s13105-010-0046-2
Keywords
Oxidative stress; Telomere length; Balloon angioplasty; Atherosclerosis
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Funding
- The Scientific and Technological Research Council of Turkey [SBAG-K-70]
- SBAG-K-70, ZK) and Ege University Research Found [04ECZ012]
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Telomeres are specialized DNA-protein complexes found at the tips of linear chromosomes. In this study, we investigated the effects of oxidative stress on telomeric length distribution of proliferating vascular smooth muscle cells following balloon injury in single or combined treatment of rabbits with either buthionine sulfoximine or taurine. Exposure to oxidative stress increased the balloon injury whereas taurine treatment significantly diminished l-buthionine-sulfoximine-related intimal hyperplasia. Our results also showed that both variables had a significant influence on mean telomeric length distribution.
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