Journal
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
Volume 64, Issue 2, Pages 149-157Publisher
SPRINGER
DOI: 10.1007/BF03168243
Keywords
Hyperglycemia; Oxidative stress; Antioxidants; Lipid peroxidation; Infection
Categories
Funding
- FIS [PI03/1710]
- Fundacion San Pablo-CEU
Ask authors/readers for more resources
Diabetic patients present an increased susceptibility to frequent and protracted infections. The recognition of an impaired immure system has implications for the diagnosis, treatment and outcome of infections. Nuclear Factor kappa B (NF-kappa B)is a redox sensitive transcription factor involved in immune response, cell proliferation and apoptosis that has been associated to the development of diabetic complications. Herein we study the effects of high glucose on oxidative stress markers (malondi-aldeyde and glutathione contents) and NF-kappa B activity in U937 cells (a human promonocytic cell line). Furtheremore effects of lutein treatment in lymphocytes from diabetic rats was studied. The results show that high glucose induces oxidative stress in immune system cells, both in vitro and in vivo, as well as an increase in their NF-kappa B activity. It is also showed that lutein, a natural antioxidant without hypoglycemiant properties, is able to prevent all the alterations observed. Thus, this study confirms the role of oxidative stress in the immune system impairment described in diabetes, and allows the proposal of antioxidants for the clinical management of the diabetes-associated susceptibility to infections.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available