Review
Biochemistry & Molecular Biology
Marilyn Hagan, Bu' Hussain Hayee, Ana Rodriguez-Mateos
Summary: Polyphenols (PPs) may have therapeutic benefits in gastrointestinal (GI) disorders like IBS or IBD, but the evidence base is inconsistent and further research is needed to clarify their effects.
Review
Immunology
Ying Gao, Peilun Ding, Junmin Wang, Caiyun Zhang, Guang Ji, Tao Wu
Summary: "Application of Metabolomics in Irritable Bowel Syndrome: A Review" provides an updated overview of metabolomics studies related to irritable bowel syndrome (IBS) in the past 5 years, including clinical studies, animal studies, and traditional Chinese medicine interventions. The review highlights the potential of metabolomics in the diagnosis and treatment of IBS, as well as the role of traditional Chinese medicine in improving IBS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Dermatology
Khalaf Kridin, Ralf J. Ludwig
Summary: Isotretinoin does not increase the risk of Crohn's disease, but it may be associated with a slight and temporary increase in the risk of ulcerative colitis. However, it can lower the risk of irritable bowel syndrome.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Health Care Sciences & Services
Yuhan Fu, Michael Kurin, Marc Landsman, Ronnie Fass, Gengqing Song
Summary: The aim of the study was to determine whether IBS is an independent risk factor for developing opioid addiction and related gastrointestinal symptoms in patients with IBD. The results showed that patients with concomitant IBD and IBS were more likely to be prescribed oral opioids and develop opioid dependence or abuse.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Hana Cipcic Paljetak, Anja Baresic, Marina Panek, Mihaela Peric, Mario Matijasic, Ivana Lojkic, Ana Barisic, Darija Vranesic Bender, Dina Ljubas Kelecic, Marko Brinar, Mirjana Kalauz, Marija Milicevic, Dora Grgic, Niksa Turk, Irena Karas, Silvija Cukovic-Cavka, Zeljko Krznaric, Donatella Verbanac
Summary: This study compares the differences in gut microbiota between newly diagnosed, treatment-naive adult inflammatory bowel disease (IBD) patients (CD and UC) with irritable bowel syndrome (IBS) patients and healthy individuals. The results show that changes in gut microbiota are detectable at the onset of disease and may play a significant role in the development of IBD.
Review
Gastroenterology & Hepatology
Arjun Gandhi, Ayesha Shah, Michael P. Jones, Natasha Koloski, Nicholas J. Talley, Mark Morrison, Gerald Holtmann
Summary: The systematic review and meta-analysis indicated that methane-positive SIBO is more prevalent in IBS, particularly in IBS-C, compared to controls, while it is less common in patients with IBD. In patients with IBD, methane-positive SIBO was significantly lower in Crohn's disease compared to ulcerative colitis. More studies are needed to establish a causal relationship due to the low quality of evidence and clinical heterogeneity in the current studies.
Article
Psychology, Biological
Andre Schulz, Sina-Katharina Welsch, Sarah Etringer, Greta Hansen, Lea Milbert, Jochen Schneider, Gennaro Taddei, Raquel Gomez Bravo, Charilaos Lygidakis, Zoe van Dyck, Annika Lutz, Paul Wilmes, Claus Vogele
Summary: This study investigates whether IBD and IBS patients have altered perception of 'natural' gastric distensions. The results show that IBD patients drink significantly more water until satiation than IBS patients, suggesting relative gastric hypersensitivity in IBS and relative hyposensitivity in IBD patients.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Medicine, General & Internal
Haoran Ke, Zitong Li, Qianyun Lin, Zefeng Shen, Ye Chen, Jinjun Chen
Summary: This study aimed to determine the causal association between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) using genetic associations and Mendelian randomization analyses. The results showed that genetically predicted IBD was associated with an increased risk of IBS, but no association between genetically influenced IBS and IBD was identified. This study confirms the causal relationship between IBD and IBS, which may impact the diagnosis and treatment of both diseases.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Vipul Yadav, Yang Mai, Laura E. McCoubrey, Yasufumi Wada, Motoyasu Tomioka, Satofumi Kawata, Shrikant Charde, Abdul W. Basit
Summary: The study demonstrates that 5-ALA has potential not only in treating gliomas but also inflammatory diseases, particularly inflammatory bowel disease. Through in vivo and ex vivo experiments, it was shown that 5-ALA is stable in the colon and can effectively improve colonic inflammation, increase heme oxygenase-1 levels, and reduce proinflammatory cytokines. This suggests that 5-ALA could be a promising addition to current IBD treatments with potential for targeted colonic delivery.
Article
Nutrition & Dietetics
Marlijne C. G. de Graaf, Corinne E. G. M. Spooren, Evelien M. B. Hendrix, Martine A. M. Hesselink, Edith J. M. Feskens, Agnieszka Smolinska, Daniel Keszthelyi, Marieke J. Pierik, Zlatan Mujagic, Daisy M. A. E. Jonkers
Summary: The study found that diet quality was lower in patients with IBD and IBS, and was associated with intestinal inflammation and gastrointestinal symptoms to varying degrees.
Review
Gastroenterology & Hepatology
Elton Dajti, Leonardo Frazzoni, Veronica Iascone, Matteo Secco, Amanda Vestito, Lorenzo Fuccio, Leonardo Henry Eusebi, Pietro Fusaroli, Fernando Rizzello, Carlo Calabrese, Paolo Gionchetti, Franco Bazzoli, Rocco Maurizio Zagari
Summary: Faecal calprotectin is a reliable test with high sensitivity and specificity for distinguishing patients with inflammatory bowel disease from those with irritable bowel syndrome. It seems to have a better sensitivity in Western countries and at a cut-off of <= 50 mu g/g.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Xiufang Cui, Haiyang Wang, Ziping Ye, Yi Li, Xinyun Qiu, Hongjie Zhang
Summary: Analysis of the intestinal microbiota revealed that in Crohn's disease patients in remission with IBS-type symptoms, there was a significant increase in Faecalibacterium and a decrease in Fusobacterium. However, in ulcerative colitis patients in remission, the changes in the abundance and structure of the gut microbiota did not explain the occurrence of IBS-type symptoms.
BMC GASTROENTEROLOGY
(2021)
Review
Medicine, General & Internal
Zhengwen Cai, Tao Zhu, Fengshuo Liu, Zixuan Zhuang, Lei Zhao
Summary: Periodontal disease and inflammatory bowel disease can coexist, potentially sharing common pathogenic microorganisms. Risk factors for both diseases appear to be similar, possibly linked through invasive microorganisms such as Porphyromonas gingivalis and Campylobacter spp.
FRONTIERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Liping Yuan, Hongyun Xiao, Huan Li, Bo Yan
Summary: The study found that APETx2 can improve intestinal motility and visceral sensitivity in PI-IBS mice through the 5-HT signaling pathway. The results showed that APETx2 significantly improved gastrointestinal function and visceral sensitivity in mice, and reduced the expression level of ASIC3 protein in the DRG of PI-IBS mice. In addition, APETx2 also increased the expression levels of 5-HT in serum and colon, CRF and 5-HT4R in the colon, and 5-HT4R in brain tissue in PI-IBS mice.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Grace L. Burns, Nicholas J. Talley, Simon Keely
Summary: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by chronic abdominal pain and altered defaecation. Research has found that small intestinal mechanosensation, altered barrier functions, and microbial imbalance are associated with IBS. The current literature suggests that the pathogenesis of IBS may involve dysfunction of the entire intestinal tract.
Article
Biochemistry & Molecular Biology
Yui Takashina, Noriko Ishizuka, Naotaka Ikumi, Hisayoshi Hayashi, Aya Manabe, Chieko Hirota, Yoshiaki Tabuchi, Toshiyuki Matsunaga, Akira Ikari
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Physiology
Hisayoshi Hayashi, Hiroki Nagai, Kou-ichiro Ohba, Manoocher Soleimani, Yuichi Suzuki
Summary: The anion exchanger DRA plays a key role in Cl- absorption and HCO3- secretion in the mouse cecum and middle-distal colon, with potential implications for water absorption and luminal acid/base regulation in these segments.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Wendy Hempstock, Noriko Ishizuka, Hisaysohi Hayashi
Summary: The Ussing chamber technique, invented by Hans Ussing in 1951, is used to study transcellular transport of sodium and physiological parameters across membranes. While preferable due to the use of native tissue, it has limitations such as low throughput, time constraints, and the need for specialized skills and training.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Medicine, Research & Experimental
Izumi Kaji, Joseph T. Roland, Sudiksha Rathan-Kumar, Amy C. Engevik, Andreanna Burman, Anna E. Goldstein, Masahiko Watanabe, James R. Goldenring
Summary: Functional loss of MYO5B leads to various deficits in intestinal epithelial cell function and results in congenital diarrheal disorder, MVID. Loss of MYO5B reduces tuft cell and increases Paneth cell populations, along with expansion of the progenitor cell zone. Notch signaling pathway appears to be maintained in MYO5B-deficient intestine.
Review
Nutrition & Dietetics
Andreanna Burman, Izumi Kaji
Summary: The small intestine plays a major role in nutrient sensing, with taste receptors responding to specific ligands like carbohydrates, fats, and proteins. Activation of nutrient sensors helps in processing incoming nutrients and defects can lead to metabolic disorders. Recent studies focus on mechanisms related to intestinal nutrient sensors and their roles in disease.
Article
Gastroenterology & Hepatology
Sudiksha Rathan-Kumar, Joseph T. Roland, Michael Momoh, Anna Goldstein, Lynne A. Lapierre, Elizabeth Manning, Louise Mitchell, Jim Norman, Izumi Kaji, James R. Goldenring
Summary: This study demonstrates the importance of Rab11FIP1 in maintaining mucosal integrity in the colon. Deficiency of Rab11FIP1 leads to mistrafficking of Rab14 and MUC13, as well as a decrease in colonic goblet cells, resulting in impaired mucosal integrity.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sarah A. Dooley, Kristen A. Engevik, Jessica Digrazia, Rachel Stubler, Izumi Kaji, Evan Krystofiak, Amy C. Engevik
Summary: Intestinal enterocytes have an elaborate apical membrane of actin-rich protrusions known as microvilli. The organization of microvilli is regulated by the intermicrovillar adhesion complex (IMAC), and this study discovered that Myosin 5b is responsible for the delivery of IMAC components to the apical membrane. Loss of Myosin 5b results in a disorganized brush border and failure of IMAC proteins to reach the distal tips of microvilli.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Cell Biology
Mikio Furuse, Daiki Nakatsu, Wendy Hempstock, Shiori Sugioka, Noriko Ishizuka, Kyoko Furuse', Taichi Sugawara, Yugo Fukazawa, Hisayoshi Hayashi
Summary: The claudin family of membrane proteins is responsible for the structure and function of tight junctions. Each claudin subtype has a unique function, and the combination of expressed subtypes determines the permeability of epithelia. Researchers attempted to reconstitute tight junctions containing only the claudin subtype(s) of interest in MDCK cells. The results showed that the reconstituted tight junctions did not contain claudin-12 and claudin-16, and overexpression of these two subtypes did not result in the reconstitution of tight junctions.
CELL STRUCTURE AND FUNCTION
(2023)
Letter
Gastroenterology & Hepatology
Andreanna Burman, Michael Momoh, Leesa Sampson, Joseph T. Roland, Evan Krystofiak, Sari Acra, James R. Goldenring, Izumi Kaji, Jennifer Skelton, Cynthia Ramos
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Physiology
Noriko Ishizuka, Mina Nagahashi, Yuina Mochida, Wendy Hempstock, Nozomi Nagata, Hisayoshi Hayashi
Summary: The morphological changes of the intestine during frog metamorphosis, including shortening and remodeling of the intestinal epithelium, are believed to be important for the transition from aquatic herbivorous to carnivorous life. However, the physiological importance of these changes is not well understood.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Wendy Hempstock, Nozomi Nagata, Noriko Ishizuka, Hisayoshi Hayashi
Summary: The large intestine plays a vital role in maintaining water and electrolyte balance. The role of paracellular transport and the physiological function of claudin-15 in the cecum and large intestine have not been fully studied. This study aimed to investigate the physiological role of claudin-15 in the cecum and large intestine using Cldn15 KO mice.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Chisato Nakamura, Noriko Ishizuka, Kanako Yokoyama, Yuyu Yazaki, Fumiya Tatsumi, Naotaka Ikumi, Wendy Hempstock, Akira Ikari, Yuta Yoshino, Hisayoshi Hayashi
Summary: Fasting and feeding affect glucose absorption function in the small intestine, with increased glucose-induced current and SGLT1 expression observed after fasting. These findings are important for understanding glucose absorption and preventing acute hyperglycemia.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Kazuya Tanifuji, Yuji Shiozaki, Megumi Koike, Minori Uga, Aoi Komiya, Mizuki Miura, Ayami Higashi, Takaaki Shimohata, Akira Takahashi, Noriko Ishizuka, Hisayoshi Hayashi, Yasuhiro Ichida, Shuichi Ohtomo, Naoshi Horiba, Ken-ichi Miyamoto, Hiroko Segawa
Summary: A novel drug EOS789 has different regulatory effects on phosphate metabolism compared to conventional therapy, and may provide better control of hyperphosphatemia by compensating for the limitations of current treatment.
JOURNAL OF MEDICAL INVESTIGATION
(2023)
Article
Pathology
Bogun Jang, Hyesung Kim, Su-Hyung Lee, Yoonkyung Won, Izumi Kaji, Robert J. Coffey, Eunyoung Choi, James R. Goldenring
Summary: Tuft cell populations increase in atrophic human gastric pathologies, metaplasia, and dysplasia, but decrease in gastric cancers. Similar findings were observed in mouse models, suggesting that, while tuft cells are associated with precancerous pathologies, their loss is most associated with the progression to invasive cancer.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Chieko Hirota, Yui Takashina, Naotaka Ikumi, Noriko Ishizuka, Hisayoshi Hayashi, Yoshiaki Tabuchi, Yuta Yoshino, Toshiyuki Matsunaga, Akira Ikari
Summary: The expression levels of CLDN2 and CLDN7 in mouse colon cells were found to change with culture days. Transcriptional factors p53 and HNF4 alpha may regulate paracellular permeability in the colon through the inverse regulation of CLDN2 and CLDN7 expression.