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Biochemistry & Molecular Biology
Rui Teixeira da Silva, Ivo F. Machado, Joao S. Teodoro, Arnau Panisello-Rosello, Joan Rosello-Catafau, Anabela P. Rolo, Carlos M. Palmeira
Summary: PEG35 preconditioning effectively ameliorates hepatic hypoxia/reoxygenation injury through the enhancement of autophagy and mitochondrial quality control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anesthesiology
Annika Raupach, Elif Karakurt, Carolin Torregroza, Sebastian Bunte, Katharina Feige, Martin Stroethoff, Timo Brandenburger, Andre Heinen, Markus W. Hollmann, Ragnar Huhn
Summary: Cardioprotective interventions such as pharmacological postconditioning using dexmedetomidine can protect hearts from ischemia and reperfusion injury, with different mitochondrial K+-channels being involved in mediating the protective effects during early and late reperfusion phases.
ANESTHESIA AND ANALGESIA
(2021)
Article
Cardiac & Cardiovascular Systems
Petra Kleinbongard, Philipp Kuthan, Chantal Eickelmann, Philipp Jakobs, Joachim Altschmied, Judith Haendeler, Arjang Ruhparwar, Matthias Thielmann, Gerd Heusch
Summary: In this study, it was found that exogenous triiodothyronine (T3) can protect human myocardium from ischemia/reperfusion injury, improving the recovery of myocardial contraction.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cell Biology
Harpreet Singh
Summary: Mitochondria are crucial organelles in cardiac physiology and their dysfunction can lead to heart failure. Ionic homeostasis in mitochondria is closely related to the inner mitochondrial membrane potential, which plays a key role in oxidative metabolism to meet the high energy demands of the heart. Multiple ion transport mechanisms are involved in maintaining the ionic homeostasis in mitochondria, making them attractive therapeutic targets for cardiac diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Review
Plant Sciences
Jose Leon, Mari Cruz Castillo, Beatriz Gayubas
Summary: Plants are highly adaptable to changing adverse environmental conditions, particularly in response to oxygen levels which have significant impacts on growth and development. The transition from hypoxia to reoxygenation can lead to cell damage due to oxidative stress, and further research is needed to understand this process. Studying molecular events related to gene expression regulation during hypoxia and reoxygenation will be crucial for improving agricultural biotechnology in the context of global climate change.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Pharmacology & Pharmacy
Weiping Li, Zhe Zhang, Jiawen Li, Jun Mu, Meng Sun, Xue Wu, Xiaochen Niu, Yang Yang, Huanle Yan, Xiaoling Xu, Chengxu Xue, Lu Qian, Ye Tian
Summary: This study aimed to investigate the protective effects of silibinin against cerebral ischemia-reperfusion injury in neuroblastoma N2a cells, as well as the mechanisms involved. The results showed that silibinin significantly reduced cell death, apoptotic rate, LDH, and ROS generation, and inhibited mitochondrial dysfunction and oxidative stress. However, the protective effects of silibinin were weakened when GAS6 was silenced.
Article
Cell Biology
Erkan Tuncay, Ivan Gando, Jian-Yi Huo, Gautham Yepuri, Natalie Sampler, Belma Turan, Hua-Qian Yang, Ravichandran Ramasamy, William A. Coetzee
Summary: Sirtuins are beneficial NAD+-dependent deacetylases that play roles in various human health conditions. In this study, researchers investigated the regulation of ATP-sensitive K+ (KATP) channels by sirtuins. They found that increasing NAD+ levels and activating sirtuins led to an increase in KATP channel current and surface expression. This finding has implications for cardiac protection against ischemic damage.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lucia Longhitano, Alfio Distefano, Paolo Murabito, Marinella Astuto, Anna Nicolosi, Giovanni Buscema, Filippo Sanfilippo, Giuseppe Lazzarino, Angela Maria Amorini, Andrea Bruni, Eugenio Garofalo, Daniele Tibullo, Giovanni Li Volti
Summary: This study evaluated the effects of Dexmedetomidine, Clonidine, and Propofol in a model of hypoxia/reoxygenation injury. The results showed that these drugs can attenuate oxidative stress and inflammation, and restore energy metabolism, with different neuroprotective profiles.
Article
Biochemistry & Molecular Biology
Yusuke Hirata, Ruiqi Cai, Allen Volchuk, Benjamin E. Steinberg, Yoshiro Saito, Atsushi Matsuzawa, Sergio Grinstein, Spencer A. Freeman
Summary: The oxidizing lipid peroxides formed during ferroptosis accumulate at the plasma membrane, causing oxidation of surface membrane lipids and membrane tension. This activates Piezo1 and TRP channels, making the membrane permeable to cations such as Na+ and Ca2+ while losing K+. In addition, the oxidation of lipids depresses the activity of the Na+/K+-ATPase, further disrupting cation gradients. Overall, increased membrane permeability to cations is a critical step in the execution of ferroptosis.
Article
Biochemistry & Molecular Biology
Michela Pecoraro, Stefania Marzocco, Ada Popolo
Summary: This study demonstrates a cooperative relationship between mCx43 and K-ATP channels in inducing cytoprotection in cardiomyocytes under hypoxic conditions. The presence of mCx43 is essential for the protective effects of diazoxide, an opener of K-ATP channels, against CoCl2-induced mitochondrial damage. These findings highlight the close functional link between mCx43 and K-ATP channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Que Bai, Qian Gao, Fangfang Hu, Caiyun Zheng, Na Sun, Wenting Chen, Jinxi Liu, Yanni Zhang, Xianglong Wu, Tingli Lu
Summary: Hypoxia is a common pathological condition, and this study found that reoxygenation can protect against hypoxia-induced acute injury and burn and promote wound healing. Reoxygenation can attenuate inflammatory cell infiltration, decrease inflammation levels, increase vascularization, and promote collagen synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gurdeep Marwarha, Oystein Rosand, Nathan Scrimgeour, Katrine Hordnes Slagsvold, Morten Andre Hoydal
Summary: This study reveals a Janus role of miR-210 in regulating apoptotic cell death of cardiomyocytes under hypoxia-reoxygenation stress. Specifically, miR-210 mitigates apoptotic cell death under hypoxia but exacerbates it during cellular reoxygenation. The underlying cellular mechanisms responsible for this dual effect of miR-210 on apoptotic cell death are also elucidated.
Article
Cardiac & Cardiovascular Systems
Miyuki Kobara, Hiroe Toba, Tetsuo Nakata
Summary: Research shows that GLP-1 analogs, like exendin-4, can protect mitochondria and improve the expression of mitochondrial quality control factors, reducing myocardial damage caused by hypoxia-reoxygenation.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Cell Biology
Barbara Fuenzalida, Sampada Kallol, Jonas Zaugg, Martin Mueller, Hiten D. Mistry, Jaime Gutierrez, Andrea Leiva, Christiane Albrecht
Summary: This study used a primary human trophoblast cell model to mimic the characteristics of preeclampsia (PE) under hypoxic conditions. The results showed that this cell model reflected important pathological processes occurring in PE, making it suitable for in vitro studies of PE.
Article
Pharmacology & Pharmacy
Liqiang Sun, Wenlong Zhang
Summary: The study demonstrates that preconditioning MSCs with ghrelin can enhance cardioprotective effects, especially in elderly subjects, following IR injury. Preconditioned MSCs increase autophagy flux by downregulating Beclin-1 and P62 protein overexpression, and increasing LC3-II expression and the LC3-II/LC3-I ratio. Moreover, combining NMN with ghrelin-preconditioned MSCs synergistically enhances protective effects on infarct size and mitochondrial function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)