Journal
JOURNAL OF PHYSIOLOGICAL SCIENCES
Volume 61, Issue 4, Pages 331-336Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s12576-011-0147-x
Keywords
Brief exercise; Swim; Mice; Isoproterenol; Cardioprotection; Tissue Doppler imaging
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Funding
- Canadian Institutes of Health Research [FRN-74733]
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We have investigated whether acute (swimming) exercise is sufficient to have sustained beneficial effects against cardiac functional decline observed after high-dose isoproterenol administration. Mice were subjected to one bout of swimming for 30 min (swim group). Twenty-four hours later, they were given isoproterenol (160 mg/kg) to cause injury. Two control groups were included, a shallow water group, for which no swimming took place, and a cage group; they were both given isoproterenol as in the swim group. Cardiac function was assessed by tissue Doppler imaging (TDI) 24 h, 2 weeks, and 4 weeks post-isoproterenol. Left ventricular (LV) systolic function including endocardial velocity and radial strain rate declined significantly in all groups at all time points after isoproterenol, compared with their pre-isoproterenol treatment values. The swim group, however, had significantly higher LV systolic function compared with either of the control groups at 24 h, and this improvement persisted 2 and 4 weeks post-treatment. There were no significant differences between the control groups at any time point. In conclusion, a single bout of swimming has sustained beneficial effects against injury, as measured by TDI, after administration of isoproterenol.
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