Journal
JOURNAL OF PHYSIOLOGICAL SCIENCES
Volume 60, Issue 3, Pages 205-212Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s12576-010-0086-y
Keywords
One and a half ventricle repair; Right ventricular stiffness; Hypoplastic right ventricle; Computational model
Categories
Funding
- Ministry of Health, Labor and Welfare of Japan [H18-nano-Ippan-003, H19-nano-Ippan-009, H20-katsudo-Shitei-007, H21-nano-Ippan-005]
- Ministry of Education, Culture, Sports, Science and Technology in Japan [20390462]
- New Energy and Industrial Technology Development Organization (NEDO) of Japan
- Grants-in-Aid for Scientific Research [22791328, 22591758] Funding Source: KAKEN
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One and a half ventricle repair (1.5VR) is a surgical option for hypoplastic right ventricle (RV). The benefits of this procedure compared to biventricular repair (2VR) or Fontan operation remain unsettled. To compare postoperative hemodynamics, we performed a theoretical analysis using a computational model based on lumped-parameter state-variable equations. We varied the RV stiffness constant (B (RV)) to simulate the various RV hypoplasia, and estimated hemodynamics for a given B (RV). With B (RV) < 150% of normal, cardiac output was the largest in 2VR. With B (RV) > 150%, cardiac output became larger in 1.5VR than in 2VR. With B (RV) > 250%, RV end-diastolic volume was almost the same between 1.5VR and 2VR, and a rapid increase in atrial pressure precluded the use of 1.5VR. These results indicate that the beneficial effect of 1.5VR depends on the RV stiffness constant. Determination of management strategy should not only be based on the morphologic parameters but also on the physiological properties of RV.
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