Journal
JOURNAL OF PHYSIOLOGICAL SCIENCES
Volume 60, Issue 5, Pages 325-330Publisher
SPRINGER TOKYO
DOI: 10.1007/s12576-010-0100-4
Keywords
Angiotensin I-converting enzyme; Gene polymorphism; Endurance performance; Genetic factor
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Funding
- Ministry of Education, Science, Sports and Culture of Japan, Tokyo, Japan [15300229]
- Fukuoka University Institute for Physical Activity
- Fukuoka University
- Grants-in-Aid for Scientific Research [15300229] Funding Source: KAKEN
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We investigated the association between the angiotensin I-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism and endurance running performance in Japanese elite runners, including several Olympic athletes. The frequency of the I/I genotype was not significantly higher and the frequency of the D/D genotype was not significantly lower in elite runners compared with non-athletes. However, the frequency of the I/D genotype tended to be lower in elite runners than in non-athletes. The best performance was significantly higher for runners with the D/D genotype than for those with the I/I genotype, and the average running speed was significantly higher for those with the combined D/D + I/D genotypes than for those with the I/I genotype. There were no I/I genotypes among the five fastest marathon runners. These results suggest that the D allele of the ACE gene I/D polymorphism is associated with a high level of human endurance.
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