Article
Environmental Sciences
Muyun Li, Wen Fang, Ruilin Meng, Jianxiong Hu, Guanhao He, Zhulin Hou, Maigeng Zhou, Chunliang Zhou, Sui Zhu, Yize Xiao, Min Yu, Biao Huang, Xiaojun Xu, Lifeng Lin, Donghui Jin, Mingfang Qin, Peng Yin, Yiqing Xu, Tao Liu, Wenjun Ma
Summary: This study aimed to investigate the combined health effects of temperature and humidity, and found that wet-cold events had a higher mortality risk compared to dry-cold events, with a higher burden for the elderly and cardiovascular disease.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Shu Jiang, Jun-Hyun Bae, Yangwenjie Wang, Wook Song
Summary: Exercise and cold exposure have been suggested as effective means to modulate adipose tissue metabolism and improve health. Myokines play a crucial role in the communication between skeletal muscle and adipose tissue. Combining exercise with cold exposure may optimize myokine profiles and health effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Sijia Liu, Fei Tian, Delin Qi, Hongfang Qi, Yang Wang, Shixiao Xu, Kai Zhao
Summary: This study used RNA-seq and LC-MS/MS metabolomics to investigate the physiological responses of Gymnocypris przewalskii, a Tibetan Plateau-specific teleost, under cold conditions. The results showed that the fish activated core genes in transcriptome transcription and triggered antioxidative metabolisms during cold acclimation. Additionally, the study revealed the important roles of gluconeogenesis and long-chain fatty acid metabolism in energy metabolism during cold stress.
Article
Medicine, Research & Experimental
Jessica Jones, Paul Reneau, Julia Matzenbacher dos Santos
Summary: Obesity is a worldwide epidemic and a major factor contributing to T2D, but the existence of MHO individuals with lower risk for metabolic complications suggests potential physiological factors at play. Lower exposure to bisphenol combined with increased physical exercise may modify metabolic pathways to inhibit insulin resistance and characterize the healthy status of MHO individuals.
MEDICAL HYPOTHESES
(2021)
Article
Biology
August C. Easton-Calabria, Jessie A. Thuma, Kayleigh Cronin, Gigi Melone, Madalyn Laskowski, Matthew A. Y. Smith, Cassandra L. Pasadyn, Benjamin L. de Bivort, James D. Crall
Summary: Social bees, such as bumblebees, play a critical role in supporting biodiversity, ecosystem function, and crop yields globally. This study examines the relationship between colony size and sensitivity to environmental stressors in bumblebees, specifically focusing on the effects of a common neonicotinoid pesticide (imidacloprid) and cold stress on behavior and colony growth. The findings suggest that colony size is a key factor in driving sensitivity to stressors and may help understand the complex impacts of pesticide exposure.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Fan Yao, Liyun Zhao, Yuxiang Yang, Wei Piao, Hongyun Fang, Lahong Ju, Qiya Guo, Dongmei Yu
Summary: The study found a relationship between famine exposure at different stages of early life and the risk of developing metabolic syndrome in adulthood, especially in females, overweight or obese participants, and those who lived in areas of severe famine, city areas, and southern China.
Article
Endocrinology & Metabolism
Ting Huang, Xiaoyi Jian, Jinglin Liu, Lan Zheng, Fang Qiu Li, Ding Meng, Tongquan Wang, Shihu Zhang, Yi Liu, Zhilong Guan, Jiadong Feng
Summary: This study verified whether exercise and/or cold exposure can improve the expression levels of ucp4c, serca, ampk alpha, camkII, sirt1, oct beta 3r, and hamlet. The results showed that exercise is the most effective way to restore cardiac dysfunction induced by a high-fat diet. Furthermore, cold exposure and exercise/cold exposure partly improved cardiac function and the normal fruit flies' cardiac function and exercise ability.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Linqiang Gong, Shiyuan Zhao, Xue Chu, Hui Yang, Yanan Li, Shanshan Wei, Fengfeng Li, Yazhou Zhang, Shuhui Li, Pei Jiang
Summary: This study investigated the metabolic changes in multiple tissues induced by cold exposure in mice. The results showed that cold exposure effectively modulated adipose tissue metabolism and improved metabolic health. Amino acids, fatty acids, and energy metabolism were found to be the most significantly altered compounds, and these changes may provide new insights for treating metabolic diseases.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Sport Sciences
Xiquan Weng, Chaoge Wang, Yu Yuan, Zhenhuan Wang, Jujiao Kuang, Xu Yan, Hao Chen
Summary: The study investigated the effects of exercise and cold exposure on insulin sensitivity and serum free fatty acid levels in diet-induced obese rats. The results showed that both exercise and cold exposure independently reduced insulin resistance. Exercise reduced serum free fatty acids, while cold exposure had no effect. There was a positive correlation between insulin resistance and serum free fatty acid levels. The combination of exercise and cold exposure reduced subcutaneous and visceral fat ratios. Additionally, exercise and cold exposure increased protein expression related to fatty acid uptake and oxidation in muscle.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Multidisciplinary Sciences
Vidmantas Vaiciulis, Jouni J. K. Jaakkola, Ricardas Radisauskas, Abdonas Tamosiunas, Dalia Luksiene, Niilo R. I. Ryti
Summary: Cold weather increases the risk of AMI, with a greater effect on men. However, there is no significant modification in risk increase by age. Understanding factors increasing susceptibility is crucial for targeted planning in cold weather.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Shanshan Guo, Yonghao Feng, Xiaopeng Zhu, Xinyi Zhang, Hui Wang, Ruwen Wang, Qiongyue Zhang, Yiming Li, Yan Ren, Xin Gao, Hua Bian, Tiemin Liu, Huanqing Gao, Xingxing Kong
Summary: In this study, the researchers elucidate an endocrine pathway involving skeletal muscle interferon regulatory factor 4 (IRF4) and follistatin-like protein 1 (FSTL1), which manipulates liver pathology in the pathogenesis of nonalcoholic steatohepatitis (NASH). They demonstrate that IRF4 can transcriptionally regulate FSTL1 and that inducing FSTL1 expression in the muscles of genetically modified mice is sufficient to restore liver pathology. Co-culture experiments reveal that FSTL1 plays a distinct role in various liver cell types via different receptors. Furthermore, the study observes a positive correlation between serum FSTL1 levels and NASH progression in humans.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Alexus McCue, Stephanie Munten, Karl-Heinz Herzig, Dominique D. Gagnon
Summary: During incremental maximal exercise to volitional fatigue in a cold environment, glucose ingestion led to increased glucose oxidation, while cold exposure increased lipid oxidation. However, metabolic flexibility was not altered in this context.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Physiology
Zhida Zhang, Le Cheng, Junxian Ma, Xiaomei Wang, Yingying Zhao
Summary: The circadian rhythm allows organisms to adapt to environmental changes through changes in physiology and behavior. This study explores the adaptive response of the circadian rhythm of liver metabolism to chronic cold exposure. The findings suggest that chronic cold exposure does not alter the rhythmic expression of core clock genes in the liver, but rather rewires the expression of clock control genes to optimize liver metabolism.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Geriatrics & Gerontology
Marni E. Shoemaker, Suzette L. Pereira, Vikkie A. Mustad, Zachary M. Gillen, Brianna D. McKay, Jose M. Lopez-Pedrosa, Ricardo Rueda, Joel T. Cramer
Summary: This study examined the differences in muscle energy metabolism and metabolic flexibility between sarcopenic and nonsarcopenic older adults. The results showed that sarcopenic individuals displayed impaired ability to adapt fuel utilization in response to feeding and exercise, indicating metabolic inflexibility. This impaired metabolic flexibility may be a mechanism underlying the loss of strength and physical function in sarcopenia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Horticulture
Cindy Dias, Tania Ribeiro, Ana Cristina Rodrigues, Antonio Ferrante, Marta W. Vasconcelos, Manuela Pintado
Summary: ‘Rocha’ pear can achieve autonomous ripening after a short duration of chilling storage, with ethylene metabolism and ester emission being key indicators of pear ripening.
SCIENTIA HORTICULTURAE
(2022)
