Copper@PMO nanocomposites as a novel reusable heterogeneous catalyst for microwave-assisted green synthesis of β-hydroxy-1,2,3-triazoles through experimental design protocol

A microwave-assisted multicomponent reaction was used to prepare a series of -hydroxy-1,2,3-triazoles in the presence of copper@PMO nanocomposites as a catalyst. Box-Behnken design and response surface methodology were used to optimize the influencing parameters such as catalyst content, reaction time and microwave power, being an economical way of obtaining the optimal reaction conditions based on restricted number of experiments. Aqueous reaction medium, easy recovery of catalyst, efficient recycling and high stability of the catalyst render the protocol sustainable and economic. Copyright (c) 2015 John Wiley & Sons, Ltd.