Article
Engineering, Biomedical
Hanneke E. M. Braakhuis, Monique A. M. Berger, Ruben G. R. H. Regterschot, Erwin E. H. van Wegen, Ruud W. Selles, Gerard M. Ribbers, Johannes B. J. Bussmann
Summary: This study found that there is no significant correlation between physical activity and lower limb motor recovery in stroke survivors. Physical activity intensity and duration showed significant increases in the early stages of recovery, while frequency and distribution did not show substantial changes.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Review
Health Care Sciences & Services
Jinlong Wu, Aihua Zeng, Ziyan Chen, Ye Wei, Kunlun Huang, Jiafeng Chen, Zhanbing Ren
Summary: Virtual reality (VR) training is an effective intervention for improving upper limb function and balance in stroke patients, as indicated by the results of a meta-meta-analysis. Significant heterogeneity in the results suggests caution in interpreting the findings. Further research is needed to assess the impact of VR training on walking ability.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Clinical Neurology
Ze-Jian Chen, Chang He, Jiang Xu, Chan-Juan Zheng, Jing Wu, Nan Xia, Qiang Hua, Wen-Guang Xia, Cai-Hua Xiong, Xiao-Lin Huang
Summary: This study aimed to compare conventional therapist-mediated training with exoskeleton-assisted anthropomorphic movement training for patients after stroke. The results showed that patients who received exoskeleton-assisted training had higher scores in the Fugl-Meyer Assessment for Upper Extremity at 4 weeks. Therefore, exoskeleton-assisted anthropomorphic movement training appears to be effective for stroke rehabilitation.
Review
Rehabilitation
Li Juan Zhao, Lin Hong Jiang, Hong Zhang, Yang Li, Pingping Sun, Yang Liu, Rui Qi
Summary: The study found that motor imagery training combined with conventional rehabilitation therapies has significant effects on the recovery of lower limb motor function in poststroke patients. It is most beneficial for improving motor function and activities of daily living in the acute phase, and for increasing walking speed in the chronic phase. Additionally, it results in greater improvements in stride length, cadence, walking ability, and balance function in the subacute phase.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2023)
Article
Biochemistry & Molecular Biology
Hongxia Zhang, Jialing Liu, Deborah Bingham, Adrienne Orr, Masahito Kawabori, Jong Youl Kim, Zhen Zheng, Tina I. Lam, Stephen M. Massa, Raymond A. Swanson, Midori A. Yenari
Summary: Motor rehabilitation strategies after unilateral stroke typically involve immobilization of the healthy limb to promote recovery of the affected limb. This study evaluated the use of botulinum toxin injections to immobilize the non-affected limb in rats with paresis. The results showed that botulinum toxin injection effectively restricted limb function.
Article
Behavioral Sciences
Ji-Ae Yu, JuHyung Park
Summary: The effects of First-Person Perspective Action Observation training and Third-Person Perspective Action Observation training on upper extremity function and activities of daily living in stroke patients were investigated. Both trainings significantly improved the upper extremity function and daily activities, with First-Person Perspective Action Observation training being more effective.
BRAIN AND BEHAVIOR
(2022)
Article
Clinical Neurology
Benedikt Taud, Robert Lindenberg, Robert Darkow, Jasmin Wevers, Dorothee Hoefflin, Ulrike Grittner, Marcus Meinzer, Agnes Floel
Summary: The study found that visuo-motor grip force tracking task training can facilitate upper extremity function recovery, but only minimal additional effects were observed with anodal tDCS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Zohreh Zare, Sam Zarbakhsh, Mohsen Tehrani, Moslem Mohammadi
Summary: In this study, we investigated the detrimental effects of estrogen and insulin deficiencies on the hippocampus, specifically by examining apoptosis-induced neuronal damage and the cholinergic system in ovariectomized and/or diabetic rat hippocampus. We also explored the potential neuroprotective effects of treadmill exercise. Our findings suggest that both ovariectomy and diabetes lead to increased apoptosis-related protein levels and decreased survival of neurons in the hippocampus. Additionally, diabetic rats showed lower acetylcholinesterase (AChE) activity, indicating impairment in the cholinergic system. However, treadmill exercise attenuated apoptosis-induced neuropathology and restored AChE activity in diabetic rats. The neuroprotective effects of exercise were mediated by the inhibition of apoptosis. Notably, the exercise protocol used in this study did not have significant anti-apoptotic and neuroprotective effects in ovariectomized-diabetic rats.
Article
Neurosciences
Hewei Wang, Xin Xiong, Kexu Zhang, Xu Wang, Changhui Sun, Bing Zhu, Yiming Xu, Mingxia Fan, Shanbao Tong, Xiaoli Guo, Limin Sun
Summary: This study aimed to investigate the neural mechanisms of motor imagery training (MIT) in stroke rehabilitation. The results showed that MIT could decrease compensatory activation at both hemispheres and reshape the functional connectivity within the ipsilesional hemisphere, promoting motor recovery in stroke patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
T. Lencioni, L. Fornia, T. Bowman, A. Marzegan, A. Caronni, A. Turolla, J. Jonsdottir, I. Carpinella, M. Ferrarin
Summary: The study found that robotic rehabilitation for post-stroke patients resulted in greater improvements in muscle synergies, especially in axial-to-proximal muscle synergies. However, both treatments had negative effects on muscle synergies controlling the distal district.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ioannis Stratos, Ingmar Rinas, Konrad Schroepfer, Katharina Hink, Philipp Herlyn, Mario Baeumler, Tina Histing, Sven Bruhn, Brigitte Mueller-Hilke, Michael D. Menger, Brigitte Vollmar, Thomas Mittlmeier
Summary: This study evaluates the potential of different training modalities in preventing muscle and bone loss in hypogonadal male rats. The findings suggest that running exercise can prevent bone loss in osteoporosis, with similar bone restoration effects observed across different training modalities.
Article
Biochemistry & Molecular Biology
Elena A. Tukhovskaya, Alina M. Ismailova, Elvira R. Shaykhutdinova, Gulsara A. Slashcheva, Igor A. Prudchenko, Inessa I. Mikhaleva, Oksana N. Khokhlova, Arkady N. Murashev, Vadim T. Ivanov
Summary: The study found that intranasal administration of DSIP for 8 days in stroke rats resulted in smaller infarction volume in the brain compared to vehicle-treated animals, although the difference was not significant. However, DSIP-treated animals showed significant improvement in motor performance.
Review
Clinical Neurology
Hong Li, Long Yan, Yulin Qian
Summary: Transcutaneous vagus nerve stimulation combined with rehabilitation training showed some improvement in upper limb motor dysfunction in post-stroke patients, but further observation is needed regarding its long-term effects, stimulation sites, stimulation parameters, combined mode with rehabilitation training, and adverse effects.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Multidisciplinary Sciences
Adriana Cancrini, Paolo Baitelli, Matteo Lavit Nicora, Matteo Malosio, Alessandra Pedrocchi, Alessandro Scano
Summary: This study investigates the effect of robot assistance on task performance and muscle synergies in healthy individuals. The results show that assistance improves task performance but has limited impact on muscle synergies.
Review
Clinical Neurology
Ippei Nojima, Hisato Sugata, Hiroki Takeuchi, Tatsuya Mima
Summary: This meta-analysis evaluated the effect sizes of clinical studies investigating the use of BCI-based rehabilitation interventions in restoring upper extremity function in post-stroke patients. The results suggest that BCI-based training is superior to conventional interventions for motor recovery of the upper limbs, with a focus on the effectiveness of sensorimotor rhythm algorithm in detecting brain activity. Further studies involving larger cohorts are needed to confirm these results due to high risk of bias and heterogeneity among the studies.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
