Article
Pharmacology & Pharmacy
Xuan Jiang, Siyu Ji, Siyuan Cui, Rong Wang, Wei Wang, Yongquan Chen, Shenglong Zhu
Summary: This study found that Apol9a regulates myogenic differentiation via the ERK1/2 pathway, providing a promising therapeutic target for intervention in obesity and obesity-induced muscle atrophy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Monica Zocchi, Daniel Bechet, Andre Mazur, Jeanette A. Maier, Sara Castiglioni
Summary: Magnesium plays a key role in skeletal muscle, and maintaining proper magnesium balance is crucial for ensuring the regenerative capacity of skeletal muscle fibers.
Article
Biochemistry & Molecular Biology
Simona Kranjc Brezar, Ajda Medved, Urska Matkovic, Gregor Sersa, Bostjan Markelc, Tim Bozic, Mihaela Jurdana, Maja Cemazar
Summary: Electrochemotherapy (ECT) is a local ablative therapy used to treat various skin and subcutaneous tumors as well as certain tumors in internal organs. The study aimed to investigate the side effects of ECT on skeletal muscle at the cellular level and determine its impact on myogenesis in a mouse muscle cell line.
BIOELECTROCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Chunfang Cheng, Shasha Zhang, Yanchun Gong, Xuanyu Wang, Shan Tang, Juan Wan, Kaizhi Ding, Chunhua Yuan, Wei Sun, Li-Hua Yao
Summary: This study aimed to investigate the effect of cordycepin on myoblast differentiation and explore the underlying molecular mechanisms. Cordycepin inhibited myogenesis by downregulating MyoD and MyoG, preserved undifferentiated reserve cell pools by upregulating Myf5 and p130, and enhanced energy reserves by decreasing intracellular ROS and enhancing mitochondrial function. The inhibitory effect of cordycepin on myogenesis was associated with ERK1/2 MAPK signaling activation. This study provides valuable insights for the prevention and treatment of degenerative muscle diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Trang Thi Huyen Dang, Jong Won Yun
Summary: BMP10 plays crucial roles in muscle physiology by promoting myogenic differentiation, glucose uptake, and lipid catabolism, mainly via the Smad 1/5/8 signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Toshio Norikura, Yutaro Sasaki, Akiko Kojima-Yuasa, Atsushi Kon
Summary: In this study, the researchers found that glyoxylic acid, an alpha-keto acid metabolite derived from glycine, promotes myogenesis and suppresses muscle atrophy induced by dexamethasone. It is also metabolized to amino acids in muscle cells. These findings suggest that glyoxylic acid may be a beneficial nutrient for patients with chronic kidney disease on a strict dietary protein restriction.
Article
Pharmacology & Pharmacy
Hiroyasu Sakai, Yuta Suzuki, Yu Miyauchi, Fumiaki Sato, Yusuke Ando, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Junzo Kamei, Tomoo Hosoe
Summary: Cancer patients often experience muscle atrophy, which is worsened by the decreased muscle regenerative capacity. Cisplatin, a cancer chemotherapeutic agent, has been found to cause muscle atrophy. This study explored the effects of cisplatin on the differentiation of myoblasts into myotubes. The results showed that cisplatin suppresses myogenesis and inhibits the expression of Sparcl1, which promotes C2C12 cell differentiation during myogenesis.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cell Biology
Mai Thi Nguyen, Wan Lee
Summary: Kank1 is a critical regulator of actin dynamics and cell proliferation in muscle progenitor cells, with its depletion impairing myogenic differentiation by promoting myoblast proliferation through F-actin-induced YAP1 nuclear translocation.
Article
Food Science & Technology
Won-Chul Lim, Eun Ju Shin, Tae-Gyu Lim, Jae Woong Choi, Nho-Eul Song, Hee-Do Hong, Chang-Won Cho, Young Kyoung Rhee
Summary: G-Rf enhances exercise endurance in mice by promoting myoblast differentiation and enhancing mitochondrial biogenesis through the AMPK and p38 MAPK signaling pathways, leading to increased energy production.
Article
Biochemistry & Molecular Biology
Song Zhang, Yuanyuan Zhang, Choulin Chen, Qingqing Hu, Yang Fu, Lingna Xu, Chao Wang, Yuwen Liu
Summary: This study utilized the robust rank aggregation method to integrate multiple RNA-Seq datasets and identified numerous differentially expressed genes (DEGs) related to muscle cell differentiation and development. Potential novel myogenic factors were discovered and the crucial role of KLF5 in regulating myogenesis was highlighted. Functional annotation suggested that KLF5 may modulate myogenesis through multiple signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yi-Ju Chen, Rathinasamy Baskaran, Ching Fang Chang, Zuhair M. Mohammedsaleh, Wan-Teng Lin
Summary: Sarcopenia, age-related muscle loss, has negative health consequences such as decreased strength and insulin resistance. The bioactive peptide DI-10 promotes myoblast differentiation and upregulates mitochondrial-related transcription factors under hyperglycemic conditions. This suggests DI-10's potential as a therapeutic candidate for preventing muscle degeneration in sarcopenia.
Article
Biochemical Research Methods
Emily A. Morris, Ahlenne Abreu, Stylianos P. Scordilis
Summary: In this study, the effects of Tamoxifen (TMX) on myogenesis in C2C12 cells (a murine skeletal muscle model) were investigated using a mass-tag approach. TMX was found to have specific effects on myogenesis and regulated a subset of proteins related to lipid and steroid metabolism. Furthermore, a powerful and adaptable pipeline for analyzing the proteomic response to in vitro treatment across every stage of muscle cell development was established.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yura Son, W. Walter Lorenz, Chad M. Paton
Summary: This study evaluated the effects of free fatty acids (FFAs) on skeletal muscle differentiation. The results showed that linoleic acid (LA) treatment increased the expression of angiopoietin-like protein 4 (ANGPTL4) and inhibited myotube formation and the expression of myogenic regulatory factors. Knockdown of ANGPTL4 reversed the effects of LA. Overall, LA inhibits skeletal muscle differentiation by suppressing the Wnt/β-catenin signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Cell Biology
Kimberly Drinkwater, Blake Anderson, Nessa Seangmany, Dylan Hampel, Aaron Mody, Minsub Shim
Summary: This study demonstrates the inhibitory role of interleukin-11 (IL11) in myogenic differentiation and identifies IL11 as a previously unrecognized mediator of cancer-associated cachexia (CAC).
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Mai Thi Nguyen, You Han Won, Tae Won Kwon, Wan Lee
Summary: This study reveals the significant role of TWF1 in the proliferation and differentiation of C2C12 myoblasts, affecting cell fate by regulating the expression of F-actin and YAP. Knockdown of TWF1 hinders myoblast differentiation and myotube formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)