Article
Chemistry, Multidisciplinary
Pierce Pham, Christian Hilty
Summary: Low-field nuclear magnetic resonance enables the measurement of biomolecular interactions without the need for a superconducting or permanent magnet. A small molecule with a hyperpolarized fluorine label is designed as a specific ligand for a target protein, and its nuclear magnetic resonance signals can be detected at a concentration of less than 100 μM. This technique allows for the measurement of ligand binding and protein-protein interactions.
Article
Food Science & Technology
Haoquan Jin, Yuxuan Wang, Bowen Lv, Kexin Zhang, Zhe Zhu, Di Zhao, Chunbao Li
Summary: In this study, a rapid and nondestructive method based on low-field nuclear magnetic resonance (LF-NMR) detection and chemometrics analysis was developed to detect adulterated avocado oil. The method showed high accuracy in distinguishing adulterated avocado oil from soybean oil (SO), corn oil (CO) or rapeseed oil (RO) adulterated avocado oil, and could accurately calculate the adulteration levels when avocado oil was adulterated by different oils.
Article
Engineering, Electrical & Electronic
Kaiwen Yao, Min Liu, Zhenyao Zheng, Tienmo Shih, Junyao Xie, Huijun Sun, Zhong Chen
Summary: Two remedies are proposed to improve the shimming speed for the search shimming method: relocating starting points closely to optima by analyzing and compensating for magnetic susceptibility effects, and improving the convergence of the simplex shimming algorithm in a multidimensional search space by modifying the simplex movement. The proposed shimming method outperforms regular shimming methods in handling complex magnetic fields and reducing shimming times, showing potential for further improvement in NMR shimming methods.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2021)
Article
Chemistry, Multidisciplinary
Sofia Marchesini, Keith R. Paton, Barry Brennan, Piers Turner, Andrew J. Pollard
Summary: Nanomaterials have a high surface-area-to-mass ratio, making surface properties crucial for product performance optimization. Characterizing nanoscale surfaces is challenging, especially in liquid dispersions, but nuclear magnetic resonance proton relaxation can quickly characterize the surface chemistry of graphitic materials.
Article
Physics, Applied
Moriyoshi Haruyama, Yuki Okigawa, Mitsuhiro Okada, Hideaki Nakajima, Toshiya Okazaki, Hiromitsu Kato, Toshiharu Makino, Takatoshi Yamada
Summary: We investigated the charge-state stabilization of shallow nitrogen-vacancy (NV) centers in (111) diamond using graphene/diamond junctions. Fluorescence stability and charge-state stability were measured on NV centers in both the graphene and graphene-free regions. The results showed that about half of the NV centers in the graphene-free region were unstable, while over 90% of the measured NV centers in the graphene region were stabilized as NV- centers. Graphene/diamond junctions significantly contribute to the charge-state stabilization of shallow NV- centers in (111) diamond.
APPLIED PHYSICS LETTERS
(2023)
Article
Food Science & Technology
Sumaiya Shomaji, Naren Vikram Raj Masna, David Ariando, Shubhra Deb Paul, Kelsey Horace-Herron, Domenic Forte, Soumyajit Mandal, Swarup Bhunia
Summary: Dyeing vegetables with harmful compounds has become a concerning public health issue in recent years, as excessive consumption of dyed vegetables can lead to severe health hazards such as cancer. This study validates the presence and quantity of dye-based adulteration in vegetables using proton nuclear magnetic resonance (NMR) technology, and proposes a low-cost detection method that can be used in various stages of the produce supply chain.
Article
Materials Science, Paper & Wood
Ramunas Digaitis, Emil E. Thybring, Lisbeth G. Thygesen, Maria Fredriksson
Summary: The study demonstrated a refined chemical modification method to improve the durability of wood in outdoor environments and control the spatial distribution of acetylation in different parts of the wood structure. This targeted acetylation procedure allowed independent alteration of wood-water interactions inside and outside of cell walls, providing a novel approach for studying wood-water interactions in moist environments and how moisture distribution affects susceptibility towards fungal decomposition.
Article
Materials Science, Characterization & Testing
Fang Hou, Zhenlin Jiang, Min Zhu, Yang Liu, Keyu Zhu, Jiamin Xu, Chaosheng Wang, Huaping Wang
Summary: This study investigated the thermo-oxidative aging process of PBAT using LF-NMR analysis and found that the degradation mechanism of PBAT during thermo-oxidative aging is random fracture. A correlation between number average molecular weight and LF-NMR relaxation time during thermo-oxidative degradation of PBAT was established. The results indicate that characterizing the molecular weight of PBAT using LF-NMR relaxation time is feasible and reliable.
Article
Biochemistry & Molecular Biology
Jiantao Chen, Yingkang Dai, Xiangjun Gong, Guangzhao Zhang
Summary: The study reveals that Gdm(+) prefers to bind to thiol or hydroxyl groups, while NH4+ tends to bind to the alpha-carboxyl group. Hydrogen bonding is observed between NH4+ and the alpha-carboxyl group, which is not involved in the interactions between Gdm(+) and cysteine.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Binhan Yu, Channing C. Pletka, Junji Iwahara
Summary: This study used NMR spectroscopy to investigate the interaction between charged proteins and anions, revealing that the number of weakly interacting anions with proteins is notably smaller than the overall charge valences. Moreover, it was observed that anions are released from the protein surface upon protein-DNA association.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Electrical & Electronic
Rongsheng Lu, Siyu Liu, Qingsong Cai, Xiaowen Jiang, Zhengxiu Wu, Zhonghua Ni, Hong Yi
Summary: In this article, a low-cost low-field nuclear magnetic resonance (NMR) cryoporometry system was developed to accurately measure the nanopore size of porous materials. The experimental results show that the proposed system has the ability to precisely control the temperature of samples and provide consistent measurements with known pore size distribution.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Article
Engineering, Electrical & Electronic
Kaiwen Yao, Enping Lin, Min Liu, Xiaobo Qu, Yu Yang, Kan Song, Junyao Xie, Huijun Sun, Zhong Chen
Summary: The proposed accelerated spectroscopic method combining nonuniform sampling with a fast and accurate low-rank reconstruction method effectively and efficiently improves the spectral resolution and sensitivity of LF NMR systems, expanding their applicability in fast detection.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Article
Construction & Building Technology
Yanlong Li, Hui Ma, Lifeng Wen, Jianpeng Yuan, Ye Zhang, Yang Li, Heng Zhou, Junhao Chen
Summary: This study evaluated the influence of pore size distribution on concrete cracking damage using low-field nuclear magnetic resonance (LF-NMR) and acoustic emission (AE) system. The results showed that as the curing age increased, the proportion of macropores decreased and the combined proportion of gel pores and transition pores increased. Additionally, the effect of the pore size distribution on concrete cracking was quantitatively described by multiple regression equations.
JOURNAL OF BUILDING ENGINEERING
(2022)
Article
Chemistry, Applied
Qizhu Zhao, Hao Tian, Long Chen, Maomao Zeng, Fang Qin, Zhaojun Wang, Zhiyong He, Jie Chen
Summary: This study demonstrates that soluble soybean polysaccharide (SSPS) has different anti-retrogradation effects on various types of starches by influencing parameters such as pasting viscosity, interstitial water content, and crystallinity. The mechanisms behind the interaction between SSPS and starch, as well as the resulting effects on retrogradation, are investigated using LF-NMR, XRD, and TPA techniques.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Multidisciplinary
Michal Terlecki, Saumya Badoni, Michal K. Leszczynski, Stanislaw Gierlotka, Iwona Justyniak, Hanako Okuno, Malgorzata Wolska-Pietkiewicz, Daniel Lee, Gael De Paepe, Janusz Lewinski
Summary: The study presents the first synthesis of highly stable ZnO NPLs with atomically precise thickness. The role of benzamidine ligands in stabilizing the surface of these nanomaterials is revealed using dynamic nuclear polarization-enhanced solid-state N-15 NMR. Bimodal stabilization allows obtaining hexagonal NPLs with modulated surface energy by the presence of ligands.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Simona Baroni, Rachele Stefania, Lionel M. Broche, Nicholas Senn, David J. Lurie, P. James Ross, Silvio Aime, Simonetta Geninatti Crich
Summary: This study introduces a novel class of MRI contrast agents with remarkable relaxation effects without the need for paramagnetic metal ions. Image acquisition at variable magnetic field strength is required for their detection using fast field cycling imaging scanners.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Biographical-Item
Radiology, Nuclear Medicine & Medical Imaging
David John Lurie, Peter Frederick Sharp
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Markus Boedenler, Oliver Maier, Rudolf Stollberger, Lionel M. Broche, P. James Ross, Mary-Joan Macleod, Hermann Scharfetter
Summary: The study introduces a model-based reconstruction method that fully utilizes the high information redundancy offered by FFC methods, achieving excellent results in low-field images and positively impacting the quality of pathology images.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lionel M. Broche, P. James Ross, Brett W. C. Kennedy, Campbell F. MacEachern, David J. Lurie, George P. Ashcroft
Summary: The study presents a novel MRI methodology, Fast Field-Cycling, to assess changes in critical proteins in human cartilage, offering potential for non-invasive monitoring of cartilage and evaluation of treatments for osteoarthritis.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2021)
Article
Oncology
Valeria Bitonto, Maria Rosaria Ruggiero, Alessandra Pittaro, Isabella Castellano, Riccardo Bussone, Lionel M. Broche, David J. Lurie, Silvio Aime, Simona Baroni, Simonetta Geninatti Crich
Summary: The study evaluated the potential of fast field-cycling H-1-NMR relaxometry as a new tool for intraoperative margin assessment, showing high reliability and the ability to assist surgeons in real-time margin evaluation. The technique is fast, does not rely on expertise, and achieves good accuracy by combining two quantifiers.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Lorenzo Nicola Mazzoni, Michael Bock, Ives R. Levesque, David J. Lurie, Giuseppe Palma
Summary: The special issue of Physica Medica - European Journal of Medical Physics, published in 2021, highlights the important points of contact between the worlds of magnetic resonance and medical physics. Featuring articles from leading groups invited by the Guest Editors, this issue offers valuable insights into the intersection of these two fields.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2021)
Article
Chemistry, Analytical
Lionel M. Broche, Karla D. Bustamante, Michael Pycraft Hughes
Summary: Complex multi-electrode arrays have been developed to study neurons, aiming to track neural action potentials across interconnected networks. An algorithm has been developed to detect the location and velocity of action potentials from multiple neurons based on data from clusters of electrodes. The system has been successfully tested using probes implanted into the locust nervous system.
Article
Oncology
Maria Rosaria Ruggiero, Hamza Ait Itto, Simona Baroni, Sandra Pierre, Jean Boutonnat, Lionel M. Broche, Silvio Aime, Francois Berger, Simonetta Geninatti Crich, Hana Lahrech
Summary: Using FFC-NMR in vivo, this study shows that T-1 relaxation measured at very low fields can distinguish between glioma invasion/migration and proliferation. The upregulation of aquaporins 4 and 1 in invasion/migration indicates their role in water exchange and modulation of T-1 relaxation in glioma. Blocking aquaporin functions could decrease the T-1 relaxation in invasion/migration glioma. These findings highlight the potential of FFC-NMR and FFC-imaging as noninvasive tools for visualizing and assessing glioma invasion/migration.
Editorial Material
Physics, Multidisciplinary
Roberta Frass-Kriegl, Lionel Marc Broche, Jean-Christophe Ginefri, Mark E. Ladd, Sigrun Roat, Mathieu Sarracanie, Simone Angela S. Winkler, Elmar Laistler
FRONTIERS IN PHYSICS
(2022)
Editorial Material
Oncology
Nanak Bhagat, Lionel Broche, T. S. Shylasree, Anne E. Kiltie, Siladitya Bhattacharya, Mahalakshmi Gurumurthy
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Engineering, Biomedical
Robert S. Stormont, Gareth R. Davies, P. James Ross, David J. Lurie, Lionel M. Broche
Summary: In this study, methods to evaluate and preserve the signal-to-noise ratio (SNR) of a low frequency coil array were investigated. It was found that ultra fine strand litz wire with a diameter of 16.2 cm exhibited lower losses and provided the mechanical flexibility needed for a conforming array. Additionally, the low noise interfacing electronics were optimized and tested to minimize SNR penalties and allow for rapid setup.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Materials Science, Biomaterials
Enza Di Gregorio, Valeria Bitonto, Simona Baroni, Rachele Stefania, Silvio Aime, Lionel M. Broche, Nicholas Senn, P. James Ross, David J. Lurie, Simonetta Geninatti Crich
Summary: This study focuses on developing innovative sensors to monitor tissue implant status non-invasively by using Fast-Field-Cycling Magnetic Resonance Imaging (FFC-MRI). These sensors, based on oligo-histidine moieties, can generate a specific quadrupolar relaxation enhancement at 1.39 MHz, serving as an indicator of scaffold integrity and exhibiting good biocompatibility.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Biographical-Item
Radiology, Nuclear Medicine & Medical Imaging
David J. Lurie, Peter F. Sharp
MAGNETIC RESONANCE IN MEDICINE
(2021)
