Article
Chemistry, Physical
Lei Wan, Rachel S. Heath, Clare F. Megarity, Adam J. Sills, Ryan A. Herold, Nicholas J. Turner, Fraser A. Armstrong
Summary: The ability to drive and observe rapid enzyme catalysis in both directions is achieved by immobilizing cascade components within electrode nanopores and coupling reactions to fast, quasi-reversible NADP(+)/ NADPH electrochemistry. By using two electrodes in sequence, each containing an enantioselective alcohol dehydrogenase for one halfcycle, efficient one-pot de-racemizers can be achieved.
Review
Chemistry, Organic
Sourav Mondal, Tamal Ballav, Krishna Biswas, Suman Ghosh, Venkataraman Ganesh
Summary: Palladium-catalyzed cascade reactions have gained much attention in organic synthesis for their efficiency and rapid transformation, serving as a powerful tool for multiple bond formations and reducing cost and time. With a wide range of functional group tolerance, these reactions have been successful in synthesizing complex molecules with biological relevance.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Mirine Leem, Deokjoon Eom, Heesoo Lee, Kwangwuk Park, Kwangsik Jeong, Hyoungsub Kim
Summary: In this study, HZO films were grown directly on single-crystalline MoS2 flakes using ALD with H2O or O3 oxidants. The O3-based ALD process oxidizes the MoS2 surface at the atomic layer level and facilitates the conformal deposition of an HZO film without surface treatment of MoS2. Annealing the O3-based HZO film significantly improves the ferroelectric properties, but also leads to diffusion of S, Hf, Zr, and O towards the Mo layer, reducing the weak HZO bonds.
APPLIED SURFACE SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Man-Bo Li, Jan-E Backvall
Summary: Palladium-catalyzed oxidations involving cascade processes have challenges in achieving high palladium efficiency and selectivity, but using heterogeneous palladium catalysts immobilized on amino-functionalized support materials has shown promising results in addressing these issues. The catalysts exhibit high activity, selectivity, and efficient recycling ability, and have been applied in various oxidative cascade reactions to access important compounds for medicinal chemistry and functional materials.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Physical
David Meis, Silvio Neumann, Volkan Filiz
Summary: By studying a group of allylated polyimides, we show the potential to undergo a series of consecutive reactions in a thermally stimulated reaction cascade, which may enhance the performance of polyimides in various applications.
CHEMISTRY OF MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Huan Xia, Na Li, Wenquan Huang, Yang Song, Yanbin Jiang
Summary: This study synthesized Imitative NH₂-MIL-101 with highly efficient peroxidase-like activity, which served as an excellent catalyst for oxidations of various peroxidase substrates and provided potential matrix for enzyme immobilization. The material also showed synergistic effect in enzymatic cascade reactions, enhancing the catalytic activity.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Organic
Sayantika Bhakta, Tapas Ghosh
Summary: Nickel-catalyzed cascade reactions have become a valuable tool in the field of organic synthesis, providing comprehensive coverage of different strategies such as photoredox decarboxylative vinylation and asymmetric reductive arylalkynation. These reactions are useful for synthesizing pharmaceutical compounds and bioactive molecules with high selectivity.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Organic
Kai Sun, Qi-Yan Lv, Ying-Wu Lin, Bing Yu, Wei-Min He
Summary: The cyano group as a radical acceptor in cascade reactions offers diverse opportunities for the convenient construction of various important heterocycles and carbocycles, leading to the rapid buildup of molecular complexity. This review focuses on summarizing the dynamic field of radical cascade processes using the cyano group as a radical acceptor, which has not been well documented so far.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Physical
Irina Gopich
Summary: The study reveals that enzyme clustering affects the kinetics of cascade reactions, with higher enzyme clusters leading to a decrease in substrate conversion rate but an increase in cluster channeling probability. Ultimately, the interplay between these factors results in an optimal number of enzyme molecules that maximizes clustering efficiency.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Review
Microbiology
Subhajit Maity, Abhik Saha
Summary: Since its emergence in late 2019, the novel coronavirus has caused a global pandemic of COVID-19 with nearly 136 million cases and approximately 3 million deaths. Studies show that SARS-CoV-2 utilizes host cell autophagy machinery for replication, and targeting this process could be a potential strategy for treating COVID-19.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Sisi Fan, Bin Ji, Yan Liu, Kexuan Zou, Zhijin Tian, Bin Dai, Daxiang Cui, Pengfei Zhang, Yonggang Ke, Jie Song
Summary: Inspired by bimolecular reactions in the cell, researchers explored the use of versatile DNA nanostructures for spatial manipulation and regulation of molecular reactions. In this study, a reconfigurable DNA origami domino array (DODA) was used as a dynamic scaffold for temporal-controlled and switchable molecular cascade reactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Multidisciplinary Sciences
William G. Tobias, Kyle Matsuda, Jun-Ru Li, Calder Miller, Annette N. Carroll, Thomas Bilitewski, Ana Maria Rey, Jun Ye
Summary: Precise control of interacting molecules was achieved, allowing for the realization of quantum phenomena. Ultracold molecules confined in optical lattice were prepared and imaged using an electric field gradient. The local chemical reaction rate was regulated by adjusting the interactions between molecules.
Article
Engineering, Environmental
Hao Yuan, Shuting Yi, Lufan Jia, Sicheng Chen, Ting Guo, Tao Meng
Summary: In this study, a living cell-inspired nanoscale multienzyme complex was designed to enable efficient cascade reactions and enhance the detection sensitivity of biosensors. The systematic study of this nanocomplex can inspire further investigation into the rules of cellular catalytic behaviors.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Weiyuan Huang, Jimin Qiu, Yuchen Ji, Wenguang Zhao, Zihang Dong, Kai Yang, Ming Yang, Qindong Chen, Mingjian Zhang, Cong Lin, Kang Xu, Luyi Yang, Feng Pan
Summary: By using LiCoO2 as a redox mediator, the decomposition of Na2CO3 can be catalyzed, enabling the effective harvest of electrochemical energy from insulating compounds and unlocking their potential capacity for energy storage.
Article
Chemistry, Multidisciplinary
Lin Wang, Shu-Rong Li, Yu-Zhen Chen, Hai-Long Jiang
Summary: In this work, nanocrystals of Cu2O were encapsulated by metal-organic frameworks (MOFs) through a simple strategy, resulting in the successful fabrication of Cu@HKUST-1 composites with uniform morphology and controlled MOF thickness. The integration of Cu NCs properties with MOF advantages helped to create a multifunctional catalyst, exhibiting cooperative catalytic activity and improved recyclability.
Article
Polymer Science
Lucas F. de Lima, Cristiane C. Maciel, Andre L. Ferreira, Rafael J. G. Rubira, Carlos J. L. Constantino, Marystela Ferreira
Summary: The controlled fabrication of layer-by-layer (LbL) films on gold substrates with different supramolecular architectures using polypyrrole (Ppy) and magnetite nanoparticles (Fe3O4-np) was reported in this study, showing the synergistic effect between Ppy and Fe3O4-np. The results indicate that the (Fe3O4-np/Ppy)(3) LbL film may have potential applications as an electrochemical or optical non-enzymatic sensor.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Electrochemistry
Cristiane C. Maciel, Amanda de S. M. Freitas, Jennifer P. Medrades, Marystela Ferreira
Summary: A flexible sensor based on PBAT mixed with graphite, modified with AuNP and copper phthalocyanine using Layer-by-Layer technique, shows high sensitivity and stability for simultaneous determination of catechol and paraquat. The sensor demonstrates good analytical performance, high recovery rates for water samples contaminated with various pollutants, and potential for portable environmental analysis applications.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Multidisciplinary Sciences
Can Wang, Rafael Furlan de Oliveira, Kaiyue Jiang, Yuda Zhao, Nicholas Turetta, Chun Ma, Bin Han, Haiming Zhang, Diana Tranca, Xiaodong Zhuang, Lifeng Chi, Artur Ciesielski, Paolo Samori
Summary: The authors functionalize monolayer transition metal dichalcogenides with hydrogen-bonded 2D supramolecular networks, leading to enhanced catalytic activity and n-doping effect for hydrogen evolution reactions.
NATURE COMMUNICATIONS
(2022)
Article
Electrochemistry
Bianca Fortes Palley, Julio Cesar Artur, Milena Nakagawa de Arruda, Gustavo Freitas de Souza, David Alexandro Graves, Ana Livia de Carvalho Bovolato, Elenice Deffune, Arthur Oscar Schelp, Emerson Sarmento Goncalves, Marli Leite de Moraes
Summary: Alzheimer's disease is a progressive neurodegenerative disease characterized by cognitive impairment and memory deterioration that requires early diagnosis for effective treatment. The use of immunosensors to detect Alzheimer's disease biomarkers provides a quick and affordable alternative for early detection. The development of Screen-Printed Electrodes (SPEs) meets the growing demand for biosensor devices.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Rafael L. H. Freire, Felipe Crasto de Lima, Rafael Furlan de Oliveira, Rodrigo B. Capaz, Adalberto Fazzio
Summary: By using first-principles calculations, this study investigates the effects of different thiol molecule linkers on the electronic properties of MoS2 nanoflake systems. The results show that the molecular linker reduces the potential barrier between nanoflakes, improving conductivity.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Multidisciplinary
Rafael Furlan de Oliveira, Veronica Montes-Garcia, Pietro Antonio Livio, Maria Begona Gonzalez-Garcia, Pablo Fanjul-Bolado, Stefano Casalini, Paolo Samori
Summary: Health monitoring is shifting towards wearable technologies, and this article reports the development of reduced graphene oxide-based liquid-gated transistors for cation sensing in artificial sweat. The sensors show excellent performance and great potential for scalable manufacturing, demonstrating a step forward in the development of wearable sensors for future health monitoring technologies.
Article
Materials Science, Multidisciplinary
Andre L. Oliveira, Amanda de S. M. de Freitas, Jessica S. Rodrigues, Karina P. P. do Carmo, Marystela Ferreira, Vagner R. R. Botaro
Summary: By adding tannin from black wattle to polystyrene, the photodegradation process can be significantly reduced. The film with 5% tannin additive showed the highest antioxidant protection among all compositions, indicating its potential application in the packaging market.
JOURNAL OF MATERIALS RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Lucas Felipe de Lima, Andre Lopes Ferreira, Amanda de Sousa Martinez de Freitas, Jessica de Souza Rodrigues, Ana Paula Lemes, Marystela Ferreira, William Reis de Araujo
Summary: This study reports a novel biodegradable composite material based on PHBV:Ecoflex and graphite microparticles for sensitive and selective electrochemical detection of CK-MB. The material exhibited a homogeneous and synergistic distribution of graphite microparticles, providing high electrical conductivity and electron transfer kinetics. Portable and disposable devices using electrochemical impedance spectroscopy (EIS) were able to detect CK-MB in a relevant clinical concentration range. The method showed good selectivity and accuracy, and the devices demonstrated potential for rapid and decentralized tests of AMI.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Jessica S. Rodrigues, Amanda de S. M. Freitas, Henrique S. M. Lopes, Ariane A. F. Pires, Ana Paula Lemes, Marystela Ferreira, Vagner R. Botaro
Summary: This study investigates the effect of different fractions of kraft lignin on the structure and performance of thermoplastic starch (TPS) matrix during photooxidative degradation. Kraft lignin from Eucalyptus urograndis wood was fractionated in ethyl acetate (EtOAc), and the fractions were added to TPS matrix films. The samples were exposed to UV-C light for accelerated aging, and their structural, thermal, morphological, and mechanical properties were analyzed. It was found that the fraction of lignin with higher phenolic hydroxyl group content provided the best photoprotection and stabilizing effect on TPS matrix.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Anderson K. Okazaki, Rafael Furlan de Oliveira, Rafael Luiz Heleno Freire, Adalberto Fazzio, Felipe Crasto de Lima
Summary: Researchers have successfully grown two-dimensional arsenic allotropes on an insulating SiC substrate using molecular beam epitaxy. The arsenene has a flat structure and follows the periodicity of the SiC surface. Ab initio simulations based on density functional theory confirm the experimental observations. The strained structure exhibits a new triangular arsenene allotrope rather than the previously predicted honeycomb structure. This strained structure undergoes a Peierls-like transition, resulting in an indirect band gap semiconductor behavior.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Matteo Sensi, Rafael Furlan de Oliveira, Marcello Berto, Marina Palmieri, Emilio Ruini, Pietro Antonio Livio, Andrea Conti, Marcello Pinti, Carlo Salvarani, Andrea Cossarizza, Joan M. Cabot, Jordi Ricart, Stefano Casalini, Maria Begona Gonzalez-Garcia, Pablo Fanjul-Bolado, Carlo Augusto Bortolotti, Paolo Samori, Fabio Biscarini
Summary: The advent of immunotherapies with biological drugs has revolutionized the treatment of cancers and auto-immune diseases. However, the presence of anti-drug antibodies (ADAs) in some patients hampers the efficacy of these drugs. This study reports an electrolyte-gated transistor (EGT) immunosensor based on reduced graphene oxide (rGO) that can detect ADAs with high sensitivity, even in the presence of their antagonist tumor necrosis factor alpha (TNF-α). The rGO-EGT is easy to fabricate, operates at low voltage, and provides a robust response within a short period of time.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Analytical
Stefanny F. Amaro, Cristiane C. Maciel, Jessica S. Rodrigues, Amanda de S. M. de Freitas, Lucas V. B. V. Fre, Anerise de Barros, Marystela Ferreira
Summary: This research aims to study flexible sensors based on a biodegradable polymer PBAT and graphite. The sensors were modified using the layer-by-layer technique to improve their electrochemical behavior for detecting paraquat. Nanostructured films were created by alternating layers of anionic and cationic materials, carbon nanotubes, and polypyrrole. The sensors showed good stability, reproducibility, and repeatability for paraquat detection.
Article
Materials Science, Multidisciplinary
Natan Luis Nozella, Joao Victor Morais Lima, Rafael Furlan de Oliveira, Carlos Frederico de Oliveira Graeff
Summary: Organic mixed ionic-electronic conductors (OMIECs) play a key role in bioelectronics, neuromorphic computing, soft robotics, and energy storage applications. In this study, a water-soluble, bio-inspired ion conductor melanin (Mel) was synthesized and blended with the conducting polymer poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) to form a new OMIEC. The Mel/PEDOT:PSS OMIEC blends showed enhanced performance in organic electrochemical transistors and supercapacitors.
MATERIALS ADVANCES
(2023)
Article
Biotechnology & Applied Microbiology
Lucas F. de Lima, Amanda de S. M. de Freitas, Cristiane Carla Maciel, Andre L. Ferreira, Marystela Ferreira, William R. de Araujo
Summary: In this study, a simple method was described for producing biodegradable and disposable thermoplastic composite electrodes. The electrodes were modified with gold nanoparticles conjugated with graphene quantum dots for sensitive and non-enzymatic glucose sensing. The modified electrodes showed enhanced electroactive area, heterogeneous electron transfer kinetics, and electrocatalytic properties for glucose sensing. The proposed method presented high sensitivity and low limit of detection, making it a potential candidate for a disposable and enzymeless electrochemical glucose sensor.
SENSORS AND ACTUATORS REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Cristiane C. C. Maciel, Andre L. L. Ferreira, Marystela Ferreira, Lucas F. de Lima, William R. de Araujo
Summary: This study proposes the manufacture and optimization of a flexible electrochemical sensor composed of graphite and the polymer PBAT. The sensor demonstrates high electroactive area, good reproducibility, and low manufacturing cost. The sensor shows potential for detecting hydroquinone in pharmaceutical ointment samples with high accuracy.
SENSORS AND ACTUATORS REPORTS
(2022)
