Review
Biochemistry & Molecular Biology
Nobuko Matsumura, Koji Aoyama
Summary: Numerous studies have shown that purine derivatives such as caffeine and uric acid have neuroprotective properties and are associated with a lower risk of neurodegenerative diseases. The mechanisms of these protective effects involve adenosine A(2A) receptor antagonism and antioxidant activity. A recent study found that another purine derivative, paraxanthine, also has similar neuroprotective effects. These purine derivatives work by increasing neuronal glutathione levels in the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Ruairi O. McCourt, Armido Studer
Summary: A 1,2-difunctionalization reaction of cyclic enol ethers mediated by bis(arylsulfonyl) peroxides is reported. Bis(nosyl) peroxide selectively adds a sulfonyl group at the 3-position of enol ethers, generating an oxocarbenium ion that is trapped by a carboxylic acid nucleophile at the 2-position. The reaction proceeds with good yield and tolerates a variety of cyclic enol ethers as well as different carboxylic acids as the oxocarbenium ion trapping reagents.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Meng Fangfeng, Zhou Jiahui, Cheng Xintao, Xu Jiahui, Kang Lei, Li Die, Wang Donghao, Bi Yuefeng
Summary: In this study, Cryptotanshinone was hybridized with water-soluble active components from Salvia miltiorrhiza, resulting in the synthesis of 42 new derivatives. Six of these derivatives showed significant cardioprotective effects. The results suggest that modifying the polarity of the derivatives during hybridization improves their activity.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jonas Everaert, Karen Leus, Hannes Rijckaert, Maarten Debruyne, Kristof Van Hecke, Rino Morent, Nathalie De Geyter, Veronique Van Speybroeck, Pascal Van Der Voort, Christian V. Stevens
Summary: Covalent triazine frameworks (CTFs) based on polydentate ligands are promising catalyst supports that combine the reactivity of homogeneous catalysts with the robustness and recyclability of heterogeneous ones. In this study, a rhodium (III) complex was immobilized on a bipyridine-based CTF for the transfer hydrogenation of N-heteroarenes in water using sodium formate as the hydrogen source. The immobilized catalyst showed excellent activity for various quinoxalines and other N-heteroarenes, and maintained high activity during recycling, making it suitable for continuous flow synthesis.
Article
Chemistry, Organic
Xiaoyi Wang, Junchun Xiang, Jie Wang, Zhilan Yu, Zi-Long Tang, Jing Xiao
Summary: We report a H3PO3/I2 mediated formation of N-benzyl benzo heterocyclic ketones from the reaction of benzo heterocyclic compounds with aromatic aldehydes or benzyl alcohol derivatives under metal-free conditions in one-pot. This novel method features a wide substrate scope, low-cost and simple condition.
Article
Chemistry, Multidisciplinary
Aoli Wu, Yongxian Guo, Meiqi Li, Qin Li, Hengchang Zang, Junbai Li
Summary: The assembly pathway and chiral transformation behavior of peptides in supramolecular peptide assemblies remain largely unknown. In this study, the assembly of an N-terminal-protected phenylalanine-tyrosine dipeptide is shown to proceed through multistep structural evolution, and the chiral assembly can be controlled by introducing a bipyridine derivative and using ultrasound or enzyme catalysis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Optics
Anuj Dalal, Kapeesha Nehra, Anjli Hooda, Devender Singh, Sumit Kumar, Rajender Singh Malik
Summary: A series of octa coordinated tris(2-benzoylacetophenonate)europium complexes were synthesized with bidentate heteroaromatic auxiliary ligands, such as 2,2'-Bipyridine (Bpy) and its derivatives. The synthesized materials were structurally analyzed using various spectroscopic techniques. The results showed that these complexes exhibited good luminescence intensity, high quantum efficiency, and long luminescence lifetime, indicating their potential as red light emitting materials in flat panel displays and optoelectronic devices.
JOURNAL OF LUMINESCENCE
(2022)
Article
Chemistry, Multidisciplinary
Pengfei Cheng, Wei Zhang, Xuqiang Zhao, Bing Yang, Yanzheng Gao
Summary: This study found that nano-goethite exhibited superior reactivity in the transformation of anthracene (ANT) and its derivatives under low moisture conditions, primarily due to single electron transfer reaction between Fe(iii) surface sites and organic reactants. The reactive sites were identified as the C9 and C10 atoms of ANT and its derivatives, which have higher Fukui function and spin density values.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Article
Chemistry, Physical
Anuj Dalal, Anjli Hooda, Kapeesha Nehra, Devender Singh, Sumit Kumar, Rajender Singh Malik, Parvin Kumar
Summary: Heteroleptic ternary terbium complexes [Tb(acac)3 L] were synthesized through a single step method using acetylacetone (acac) as the chromophoric and substituted 2,2'-bipyridine as auxiliary (L) moieties. The synthesized complexes exhibited green emission and high color purity, indicating their potential application in displays.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Organic
Freya M. M. Harvey, Alexandra H. H. Heidecker, Christian Merten, Thorsten Bach
Summary: Allenes with different substituents at their terminal carbon atom exhibit axial chirality and can be obtained in enantiopure form through a photochemical deracemization protocol. This study investigates the conditions under which allenoic acid derivatives undergo a Diels-Alder reaction with 1,3-cyclopentadienes and the resulting products. Cyclic derivatives (lactams, lactones) exhibited an exo-selective reaction catalyzed by the Lewis acid Eu(fod)(3), while acyclic derivatives mainly produced endo-products (with EtAlCl2 as the preferred Lewis acid). The exocyclic double bond exhibited excellent diastereoselectivity and achieved near-perfect chirality transfer. The method was successfully applied to the synthesis of sesquiterpenes beta-santalol (1) and 10(E)-beta-santalic acid (13).
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Applied
Jiaqi Zhao, Feng Wei, Hong Liu, Rui Qin, Xinzhou Yang
Summary: Three previously undescribed compounds, including two aromatic acid derivatives and one xanthone, were isolated from the aerial part of Hypericum hengshanense. The structures of these new compounds were determined using 1D and 2D NMR and MS data, and the absolute configurations of two compounds were determined using quantum chemical ECD calculations. These compounds showed weak cytotoxicity against Hep-2 human cancer cell lines.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Medicinal
Jun Chen, Taige Zhao, Fengming He, Yijing Zhong, Susu Wang, Ziqing Tang, Yingkun Qiu, Zhen Wu, Meijuan Fang
Summary: A novel RXR alpha ligand BPA-B9 was synthesized, which targets the pRXR alpha-PLK1 interaction and shows excellent anti-proliferative activity against MDA-MB-231 cells. BPA-B9 also exhibits better pharmacokinetics and significant anticancer efficacy in vivo with no considerable side effects.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Manoj Kumar, Anupam Singh, Benedetta Del Secco, Maksim Baranov, Geert van den Bogaart, Stefano Sacanna, Shashi Thutupalli
Summary: In this study, the use of colloid supported lipid bilayers (CSLBs) for assembling colloidal structures is explored. It is found that the curvature anisotropy of the colloids drives a sorting of the lipids in the membrane. This property is then utilized to create shape-anisotropic patchy colloids, which enables the directed assembly of colloidal links and opens up possibilities for creating heterogeneous and flexible colloidal structures.
Article
Materials Science, Paper & Wood
Martin Gericke, Jonas Bergrath, Margit Schulze, Thomas Heinze
Summary: Composite nanoparticles consisting of lignin and polysaccharide derivatives were prepared. The polysaccharide derivatives acted as biocompatible matrices while lignin had therapeutic potential. By dialyzing organic solutions, nanocomposites with particle sizes of 200-550 nm were obtained. The study laid the foundation for future research on the pharmaceutical potential and biocompatibility of composite nanoparticles of lignin and polysaccharide derivatives.
Article
Engineering, Environmental
Lei Zhang, Minghui Wang, Haiyang Cui, Jie Qiao, Dongsheng Guo, Biao Wang, Xiujuan Li, He Huang
Summary: The study demonstrates that humic acid (HA) or Tween80 can significantly enhance the degradation efficiency of phenanthrene (PHE) by B. subtilis ZL09-26, by jointly regulating specific cellular pathways and increasing metabolic pathways, thereby improving PHE transport, emulsification, and degradation.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Clinical Neurology
Xicai Sun, Quan Liu, Hongmeng Yu, Huan Wang, Weidong Zhao, Yurong Gu, Houyong Li, Keqing Zhao, Xiaole Song, Dehui Wang, Juan C. Fernandez Miranda, Carl H. Snyderman
Summary: Temporalis muscle flap (TMF) can be effectively used for reconstruction of skull base defects after expanded endoscopic nasopharyngectomy, reducing the occurrence of serious complications in patients with recurrent nasopharyngeal carcinoma.
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2022)
Article
Chemistry, Multidisciplinary
Meihao Xia, Yao Chen, Ziran Chen, Wenhao Yu, Haomin Cheng, Chun Feng, Hailiang Ni, Biqin Wang, Keqing Zhao, Ping Hu
Summary: A 1,4-disubstituted 1H-1,2,3-triazoles was successfully synthesized through a catalyst-free click reaction, leading to the formation of a non-covalent palladium chloride complex with unique liquid crystal properties but relatively poor thermal stability. X-ray crystallographic analysis revealed the trans-trans isomeric orientation of the complex, which also showed strip-shaped nanostructures on an oriented graphite substrate.
Article
Chemistry, Applied
Hang Lin, Qiu-Bing Lv, Hai-Feng Wang, Ke-Qing Zhao, Ping Hu, Bi-Qin Wang, Benoit Heinrich, Bertrand Donnio
Summary: Liquid-crystalline D-A dyads and A-D-A triads have been synthesized via Pd-catalyzed Sonogashira coupling/DBU-promoted cyclization reactions, showing spontaneous self-organization into columnar hexagonal or rectangular mesophases over broad temperature ranges. The study reveals that perylenediimide is a stronger electron acceptor compared to benzoperylenediimide, and these donor-acceptor systems have potential applications in various optoelectronic devices.
Article
Chemistry, Multidisciplinary
Yu Du, Cai-Li Zhao, Sheng-Yuan Fan, Wen-Hao Yu, Shi-Kai Xiang, Ke-Qing Zhao, Chun Feng, Bi-Qin Wang
Summary: Seven hydrazide-functionalised triphenylenedicarboxyimides (TDIs) with different polar substitutes connected to the imide N atom were studied to investigate the impact of hydrogen bonding and polar substituents on their mesomorphic properties. It was found that hydrogen bonding was not strong enough to stabilize the columnar mesophase, while dipole-dipole effects favored mesophase stabilities. Additionally, the position of lateral substituents had a significant impact on self-assembly by affecting the overall dipole moment.
Article
Chemistry, Applied
Xue Xia, Cai-Li Zhao, Hong-Tian Xu, Wen-Hao Yu, Shi-Kai Xiang, Lai-Cai Li, Ke-Qing Zhao, Chun Feng, Bi-Qin Wang
Summary: This article describes the synthesis and self-assembly behavior of a series of ten optically active triphenylenedicarboxyimide (TDI) derivatives with a stereogenic center. The TDIs show an enantiotropic hexagonal columnar mesophase with high clearing temperatures. Chiral supramolecular structures are observed in the columnar mesophase of three pairs of chiral TDIs. The axially connected aromatic ring at the stereocenter provides steric repulsion upon stacking, leading to the formation of chiral supramolecular structures. The configuration of the stereogenic center is not the only factor responsible for inducing helical structures in solution.
Article
Chemistry, Multidisciplinary
Dan Xiong, Xiaoping Xiong, Ziran Chen, Wenhao Yu, Chun Feng, Hongmei Chen, Hailiang Ni, Biqin Wang, Keqing Zhao, Ping Hu
Summary: This study investigates the effects of alkyl chain and halogen atom substitution on the mesophase behavior of 1,2,3-triazole-based compounds, aiming to develop novel nematic-phase liquid-crystal materials for optical and photovoltaic devices. The introduction of halogen atoms at the 5-position of 1,2,3-triazole greatly broadens the mesogenic temperature range.
Article
Polymer Science
Jian Chen, Ya Wen, Lingyi Zeng, Xinchun Wang, Hongmei Chen, Wei Min Huang, Yuefeng Bai, Wenhao Yu, Keqing Zhao, Ping Hu
Summary: In this paper, a UV cross-linkable vitrimer-like polymer is synthesized, and it is found that the density of cross-linking and the mechanical properties of the resulting polymers can be tailored via varying the amount of photo-initiator and UV exposure time. The polymers also exhibit good shape memory effect, making them suitable for additive manufacturing applications.
Article
Chemistry, Multidisciplinary
Wenzhe Li, Ling Zhu, Kaidi Li, Siyuan Ye, Huayi Wang, Yadong Wang, Jianchao Xue, Chen Wang, Shanqing Li, Naixin Liang, Yanlian Yang
Summary: This study establishes a machine learning-assisted method for analyzing the expression of EGFR and CXCR4 in serum sEVs and demonstrates their potential as diagnostic and prognostic markers for NSCLC.
Article
Chemistry, Organic
Ya-Qiong Qi, Shuai Liu, Yan Xu, Yang Li, Tong Su, Hai-Liang Ni, Yuanji Gao, Wenhao Yu, Peng Cao, Ping Hu, Ke-Qing Zhao, Bi-Qin Wang, Bin Chen
Summary: We report an efficient Ni-catalyzed three-component cross-electrophile coupling reaction, which accomplishes dicarbofunctionalization of 1,3-dienes by forming two new C-C bonds in one reaction.
Article
Immunology
Yue Ma, Le Shi, Keqing Zhao, Chunquan Zheng
Summary: The study discovers that lncRNA FR215775 is highly expressed in primary Th2 cells of mice. Inhibition of lncRNA FR215775 leads to suppressed proliferation of CD4+ T cells and decreased expression of IL-4 and IL-5 in the cell culture supernatant. Silence of lncRNA FR215775 results in milder allergic symptoms and reduced levels of immunoglobulin E in AR mice.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Otorhinolaryngology
Yujie Cao, Xianting Hu, Chun Zhou, Keqing Zhao, Yaoming Zheng, Wenxiu Jiang, Dehui Wang, Huabin Li
Summary: The study found that IL-1 alpha is significantly increased in NP tissues of CRSwNP patients in China and is mainly located in epithelial cells and neutrophils. IL-1 alpha in polyp tissues is associated with the production of IL-8, IL-1 beta, IL-6, IL-4, and IL-13, as well as tissue neutrophil infiltration. In vitro experiments showed that several stimuli, including poly (I:C), lipopolysaccharides, Flagellin, R848, and cytokines (IL-4, IL-5, and IL-13), increase the expression of IL-1 alpha in cultured NECs, and recombinant IL-1 alpha promotes the production of IL-8 and CXCL1.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ming-Mei Zhou, Jiao He, Hui-Min Pan, Qing Zeng, Hang Lin, Ke-Qing Zhao, Ping Hu, Bi-Qin Wang, Bertrand Donnio
Summary: This study describes a efficient transition-metal-free arene-fluorine nucleophilic substitution reaction for the straightforward synthesis of several Fluorinated Polycyclic Aromatic Hydrocarbons, and reports the investigation of their liquid crystalline and optical properties.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Mengting Chen, Xiaocui Fang, Rong Du, Jie Meng, Jingyi Liu, Mingpeng Liu, Yanlian Yang, Chen Wang
Summary: A new therapeutic strategy for chronic myeloid leukemia (CML) was discovered utilizing a peptide (WIP2W) that specifically inhibits the WT1 protein, inducing cell cycle arrest and cytotoxicity. A micellar formulation (M-WIP2W) enhances intra-tumoral accumulation and effectively inhibits tumor growth.
Article
Pharmacology & Pharmacy
Mengting Wang, Ting Xu, Lin Shen, Jian Li, Ling Zhu, Chen Wang, Zhiyuan Hu, Ping Li, Yanlian Yang, Xicheng Wang
Summary: For metastatic colorectal cancer patients with human epidermal growth factor receptor 2-positive (HER2+ mCRC), anti-HER2 therapy has shown benefits, but the current HER2 testing using tumor biopsy is controversial. Noninvasive enumeration and HER2 phenotyping on circulating tumor cells (CTCs) may provide more accurate HER2 diagnosis. This study assessed HER2((0/1+/2+/3+)) CTCs using TUMORFISHER in 40 mCRC patients (20 HER2+; 20 HER2-negative) and found that CTC enumeration and ctcHER2 phenotyping could be prognostic and predictive biomarkers for HER2+ mCRC with anti-HER2 therapy.
ADVANCED THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Wen-Jing Deng, Shuai Liu, Hang Lin, Ke-Xiao Zhao, Xiao-Yan Bai, Ke-Qing Zhao, Ping Hu, Bi-Qin Wang, Hirosato Monobe, Bertrand Donnio
Summary: In this study, two series of regio-isomeric liquid crystalline systems were synthesized and the influence of core topology on their properties was investigated. The beta-isomers showed more extended mesophase ranges, higher phase transition temperatures, and better organic gelling abilities compared to the alpha-isomers. Additionally, the beta-isomers exhibited higher charge carrier mobilities.
NEW JOURNAL OF CHEMISTRY
(2022)
