Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 118, Issue 18, Pages 4920-4931Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp500074g
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Funding
- NSFC [21125316, 21204095, 51335010]
- 973 projects [2013CB632300]
- CAS [KJZD-EW-M01]
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The fabrication of core/shell charged polymer brushes-grafted hollow silica nanoparticles (PSPMA-g-HSNPs) is reported. Because of the excellent hydration capability of the shells consisting of charged polymer brushes, the functional nanoparticles can achieve a good lubricating effect in aqueous media via hydration lubrication mechanism. The mesoporous hollow silica cores endow the nanoparticles with drug loading-release capability. Aspirin, as a useful drug for treating arthritis, was employed to carry out in vitro drug loading and release studies. It is clear that brushes-modified hollow silica exhibited long-term drug release performance. The combination of lubrication and drug loading capabilities results in the great clinical potential of new multifunctional nanoparticles as injectable joint lubricant fluid in arthritis treatment.
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