Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 113, Issue 27, Pages 9205-9215Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp9035474
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- Fondazione Banco di Sardegna (Sassari. Italy)
- Scientific Park Sardegna Ricerche (Pula. CA, Italy)
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The entrapment of AMP, GMP, CMP, and UMP nucleotides along with two different AMP-based nucleolipids (hydrophobically functionalized nucleotides) inside the liquid crystalline phases of the monoolein/water system is investigated through optical microscopy, small-angle X-ray diffraction (SAXRD), and nuclear magnetic resonance (NMR) techniques. As ascertained mainly through (31)P NMR experiments, when included within the Cubic phase, the various nucleotides undergo a slow hydrolysis of the sugar-phosphate ester bond, induced by specific interactions at the monoolein-water interface. Upon aging, the degradation of the nucleotides causes a cubic-to-hexagonal phase transition. Differently, neither hydrolysis nor alterations of the monoolein self-assembly are observed when the nucleotides are included as lipid derivatives within the cubic liquid crystalline phase. A model that explains both the hydrolysis and the consequent phase transition is presented.
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