Article
Chemistry, Multidisciplinary
Jin Wang, Juan Song, Xian Zhang, Shu-Min Wang, Bin Kang, Xiang-Ling Li, Hong-Yuan Chen, Jing-Juan Xu
Summary: Real-time observation of receptor tyrosine kinases family (RTKs) at single-molecule level based on plasmon rulers enables precise regulation and dynamic monitoring of dimerization process. These nanoprobes show substantial application in regulating RTKs protein dimerization/phosphorylation and activating downstream signaling pathways.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Oncology
Tresa M. McGranahan, Alipi Bonm, Jennifer M. Specht, Vyshak Venur, Simon S. Lo
Summary: This paper reviews the treatment options for patients with HER2+ breast cancer brain metastasis and provides a simplified algorithm for when to consider delaying local treatments.
Article
Biochemistry & Molecular Biology
Yayun Gu, Huanyao Gao, Huan Zhang, August John, Xiujuan Zhu, Suganti Shivaram, Jia Yu, Richard M. Weinshilboum, Liewei Wang
Summary: The TRAF4-SMURF2 complex is identified as a potential mechanism for maintaining HER2 signaling in HER2-positive breast cancer cells during Trastuzumab treatment. Knockdown of TRAF4 reduces HER2 stability and improves Trastuzumab sensitivity.
Article
Oncology
Arnaldo Marin, Abdullah Al Mamun, Hima Patel, Hiroaki Akamatsu, Dan Ye, Dhivya R. Sudhan, Lisa Eli, Katherine Marcelain, Benjamin P. Brown, Jens Meiler, Carlos L. Arteaga, Ariella B. Hanker
Summary: This study reveals the driver function of acquired HER2 mutations in resistance to HER2 tyrosine kinase inhibitors, and provides a potential treatment strategy to overcome this resistance.
Review
Cell & Tissue Engineering
Hendrik Setia Budi, Firdaus Nuri Ahmad, Harun Achmad, Mohammad Javed Ansari, Maria Vladimirovna Mikhailova, Wanich Suksatan, Supat Chupradit, Navid Shomali, Faroogh Marofi
Summary: Due to the overexpression or amplification of human epidermal growth factor receptor 2 (HER2) with poor prognosis in various human tumors, recent studies have focused on HER2-targeted therapies. Immunotherapy using HER2-specific chimeric antigen receptor (CAR) expressing immune cells has shown great anti-tumor potential and attracted increasing attention.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, Research & Experimental
Cancan Lyu, Yuanchao Ye, Maddison M. Lensing, Kay-Uwe Wagner, Ronald J. Weigel, Songhai Chen
Summary: In HER2(+) breast cancer, overactivation of HER2 leads to aberrant G(i/o)-GPCR signaling, promoting cancer progression and resistance to HER2-targeted therapy. Pharmacologically deactivating GPCR signaling can block tumor growth and enhance therapeutic efficacy.
Article
Multidisciplinary Sciences
Nindo B. Punturi, Sinem Seker, Vaishnavi Devarakonda, Aloran Mazumder, Rashi Kalra, Ching Hui Chen, Shunqiang Li, Tina Primeau, Matthew J. Ellis, Shyam M. Kavuri, Svasti Haricharan
Summary: Resistance to endocrine treatment in ER+ breast cancer patients is linked to activation of HER2 due to loss of mismatch repair, and inhibiting HER2 restores sensitivity to treatment. Loss of MutL and upregulation of HER2 are associated with sensitivity to HER inhibitors in ER+/HER2(-) patients.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Xue Bai, Pengyu Sun, Xinghao Wang, Changkun Long, Shuyun Liao, Song Dang, Shangshang Zhuang, Yongtao Du, Xinyi Zhang, Nan Li, Kangmin He, Zhe Zhang
Summary: HER2 belongs to the human epidermal growth factor receptor tyrosine kinase family and its overexpression or hyperactivation is a leading cause for multiple types of cancers. The molecular details for heterodimer assembly between HER2 and EGFR are not completely understood.
Article
Multidisciplinary Sciences
Devan Diwanji, Raphael Trenker, Tarjani M. Thaker, Feng Wang, David A. Agard, Kliment A. Verba, Natalia Jura
Summary: This study reveals the dynamics of the HER2-HER3 dimer upon binding of NRG1 beta using cryo-electron microscopy. The analysis of the structure shows that the mutant HER2 can interact with the dimerization arm of HER3 to stabilize the dimerization interface. The research suggests that both therapeutic agents and oncogenic mutations exploit the intrinsic dynamics of the HER2-HER3 heterodimer.
Article
Dermatology
Musin Kelel, Ruey-Bing Yang, Tsen-Fang Tsai, Pi-Hui Liang, Fu-Yu Wu, Yu-Tien Huang, Ming-Fong Yang, Yu-Ping Hsiao, Li-Fang Wang, Chen-Fen Tu, Fu-Tong Liu, Yungling L. Lee
Summary: The study reveals that FUT8 remodeling of EGFR plays a critical role in the development of psoriasis phenotypes and is associated with disease severity. FUT8 gain of function promotes cell proliferation, while short hairpin FUT8 reduces proliferation and alters the cell cycle.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Jun Cao, Yuee Teng, Huiping Li, Lili Zhang, Quchang Ouyang, Weimin Xie, Yueyin Pan, Zhenchuan Song, Xiaoling Ling, Xiaohong Wu, Jingwei Xu, Li Li, Liping Ren, Hong Wang, Dongxian Zhou, Jing Luo, Xichun Hu
Summary: This study investigated the efficacy and safety of pyrotinib plus capecitabine in HER2-positive advanced breast cancer patients with primary resistance to trastuzumab. The results showed that this combination therapy can be considered as a treatment option for these patients.
Article
Biochemical Research Methods
Anna Mestre Borras, Charles Dahlsson Leitao, Stefan Stahl, John Lofblom
Summary: Conditional activation of engineered affinity proteins can be achieved by proteolytic processing. In this study, an anti-idiotypic masking domain was generated to block EGFR-binding on cancer cells when fused to an affibody molecule via a protease cleavage site linker. The results demonstrate the potential therapeutic and diagnostic applications of this approach and suggest further studies are warranted.
Article
Oncology
Mengkai Yang, Tao Zhang, Yangfeng Zhang, Xiaojun Ma, Jing Han, Ke Zeng, Yafei Jiang, Zongyi Wang, Zhuoying Wang, Jing Xu, Yingqi Hua, Zhengdong Cai, Wei Sun
Summary: The study revealed that MYLK4 promotes the growth and metastasis of osteosarcoma by activating the EGFR signaling pathway. Additionally, the combination of MYLK4 and EGFR inhibitors showed synergistic effects on the growth and metastasis of OS in vitro and in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biology
Yongjian Huang, Jana Ognjenovic, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam, John Kuriyan
Summary: Research has shown that the EGFR receptor can adopt different conformations of the extracellular module when binding to different ligands, with implications for intracellular signaling pathways.
Article
Nanoscience & Nanotechnology
Lingzhou Zhao, Jiali Gong, Qinli Qi, Changcun Liu, Hongxing Su, Yan Xing, Jinhua Zhao
Summary: The unique structure of nanobodies is advantageous for the development of radiopharmaceuticals for nuclear medicine. In this study, a 131I-labeled anti-HER2 nanobody was generated and evaluated as a targeted radionuclide therapy agent for HER2-positive breast cancer. The results showed that 131I-NM-02 had satisfactory radiochemical purity and stability, and demonstrated good therapeutic potential and organ compatibility in HER2-positive tumors.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Binbin Zheng, Jiaojiao Xu, Gaoxian Chen, Sihang Zhang, Zeyu Xiao, Wei Lu
ADVANCED FUNCTIONAL MATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Jiaojiao Xu, Binbin Zheng, Sihang Zhang, Xueling Liao, Qinli Tong, Guoguang Wei, Sheng Yu, Gaoxian Chen, Aihua Wu, Shuai Gao, Yuyi Qian, Zeyu Xiao, Wei Lu
Summary: The study presents a novel adoptive macrophage therapy using copper sulfide nanoparticles to induce ROS production and inhibit tumor growth, improve the tumor microenvironment, elicit systemic antitumor immunity, thus prolonging the survival time of tumor patients.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Shuai Gao, Sheng Yu, Yongming Zhang, Aihua Wu, Sihang Zhang, Guoguang Wei, Hao Wang, Zeyu Xiao, Wei Lu
Summary: A new type of photosensitizer was designed in this study, capable of emitting fluorescence in the NIR-II window and producing sufficient singlet oxygen. The nanoparticles demonstrated high efficiency in tumor imaging and photodynamic therapy in mice.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Chenchen Fan, Na Zhao, Kai Cui, Gaoxian Chen, Yingzhi Chen, Wenwei Wu, Qingyun Li, Yanna Cui, Ruike Li, Zeyu Xiao
Summary: The study developed a modularized surface-enhanced Raman spectroscopy (SERS) labeling strategy for ultrasensitive exosome detection, enabling successful tumor monitoring and differentiation between cancer patients and healthy subjects.
Article
Chemistry, Multidisciplinary
Fangfang Xia, Axin He, Haitao Zhao, Yang Sun, Qiao Duan, Sk Jahir Abbas, Jianjun Liu, Zeyu Xiao, Weihong Tan
Summary: Functionally modified aptamer conjugates are promising tools for targeted imaging or treatment of various diseases. However, their broad applications are limited by in vivo instability. To overcome this challenge, a covalent modification-free strategy using gold nanoclusters to enhance the in vivo stability of aptamers has been developed, leading to improved tumor-targeted recognition and retention.
Article
Chemistry, Multidisciplinary
Kai Cui, Yongming Zhang, Gaoxian Chen, Yanna Cui, Wenwei Wu, Na Zhao, Tize Liu, Zeyu Xiao
Summary: This article introduces a polymer probe for ultrasensitive in vivo Raman imaging. The polymer emits strong Raman signals under near-infrared excitation and enables imaging of micrometastasis and microvasculature.
Editorial Material
Biotechnology & Applied Microbiology
Lian Duan, Fan Zheng, Didier Merlin, Hangxiang Wang, Zeyu Xiao, Bo Xiao
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Yongming Zhang, Yanna Cui, Mingwang Li, Kai Cui, Ruike Li, Wenhui Xie, Liu Liu, Zeyu Xiao
Summary: This study presents a DNA-assembled nanomaterial that achieves uniform distribution of photothermal agents in tumor tissues, enhancing photothermal therapy efficiency. By utilizing the explosive dissociation of hydrogen bonds, the large-sized nanomaterial is broken down into smaller photothermal agents, promoting their diffusion and improving their anti-tumor effects.
Article
Chemistry, Multidisciplinary
Liwen Hong, Gaoxian Chen, Zhengwei Cai, Hua Liu, Chen Zhang, Fei Wang, Zeyu Xiao, Jie Zhong, Lei Wang, Zhengting Wang, Wenguo Cui
Summary: This study developed an injectable protein hydrogel with anti-thrombosis and anti-inflammation capabilities to impede the vicious cycle between inflammation and microthrombosis in inflammatory bowel disease. The hydrogel exhibited excellent self-healing ability, injectability, biocompatibility, and sustained drug release. In vivo experiments showed that the hydrogel can inhibit inflammatory microthrombosis with reduced bleeding risk.
Article
Chemistry, Multidisciplinary
Yulin Du, Yifan Lyu, Shiquan Li, Ding Ding, Jianghuai Chen, Cai Yang, Yang Sun, Fengli Qu, Zeyu Xiao, Jianhui Jiang, Weihong Tan
Summary: Cell-specific aptamers are a strong tool for studying membrane receptors at the single-molecule level. Ligand dilution analysis (LDA) is proposed as a random sampling-based strategy to study aptamer-based receptors. This strategy allows for the calculation of receptor density, colocalization and differentiation of aptamer and monoclonal antibody binding, and determination of binding site and aptamer-receptor binding mode.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Kai Cui, Ruike Li, Yongming Zhang, Yuanyuan Qiu, Na Zhao, Yanna Cui, Wenwei Wu, Tize Liu, Zeyu Xiao
Summary: This study presents a molecular planarization strategy for adjusting the signal shift of Raman probes. By modifying the backbone of P3HT polymer, we obtained a PCPDT probe with a blueshifted characteristic signal. The PCPDT probe successfully avoids interference with lipid signals in tissue and enables high-precision intraoperative imaging.
Article
Pharmacology & Pharmacy
Yanna Cui, Hui Yan, Haoze Wang, Yongming Zhang, Meng Li, Kai Cui, Zeyu Xiao, Liu Liu, Wenhui Xie
Summary: This research presents a new treatment strategy for reversing radio-resistance in lung cancer by using multiple mild hyperthermia treatments. By injecting nanotheranostics and irradiating with laser, oxygen levels in tumors can be improved and tumor hypoxia can be alleviated, leading to effective tumor inhibition.
Article
Nanoscience & Nanotechnology
Yang Sun, Die Yu, Xinyao Geng, Ding Ding, Yu Yang, Zhuang Liu, Zeyu Xiao, Ruowen Wang, Weihong Tan
Summary: The modification of siRNA with artificial base F can improve its properties, such as tumor specificity and cellular uptake. The introduction of F base enables siRNA to interact with plasma proteins, especially serum albumin. Experimental results show that F base modification enhances the specific accumulation of siRNA in tumor tissue, prolongs its circulation time, and improves tissue permeability. Mechanistic studies reveal that the F base facilitates the formation of a stable siRNA-albumin complex, which is responsible for the selective delivery of siRNA to tumor tissues and its cellular internalization.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Can Luo, Lei He, Fengming Chen, Ting Fu, Penghui Zhang, Zeyu Xiao, Yanlan Liu, Weihong Tan
Summary: The rapid advancement of nanotechnology has opened up significant opportunities in various biomedical applications, particularly in disease diagnosis and therapy where biomolecular logic gates integrated with nanostructures play a crucial role. Stimulus-responsive nanomaterials containing molecular logic gates have evolved from simple to sophisticated Boolean logic computations, offering improved specificity and reduced off-target effects. The review provides an overview of the development and applications of these smart nanomaterials in cell profiling, sensing, imaging, and drug delivery, while also discussing future perspectives and challenges in this emerging field.
CELL REPORTS PHYSICAL SCIENCE
(2021)
Review
Nanoscience & Nanotechnology
Na Zhao, Yingzhi Chen, Gaoxian Chen, Zeyu Xiao
ACS APPLIED BIO MATERIALS
(2020)
