Article
Chemistry, Physical
Alessandra Luchini, Federica Sebastiani, Frederik Gronbaek Tidemand, Krishna Chaithanya Batchu, Mario Campana, Giovanna Fragneto, Marite Cardenas, Lise Arleth
Summary: Peptide discs, resembling 10 nm discoidal lipid bilayers, can be used as precursors for Supported Lipid Bilayers (SLBs) without the need to alter any experimental variables, allowing for faster formation compared to vesicle fusion. SLBs can be successfully formed from both synthetic and natural lipid mixtures, with traces of 18A peptide at the support surface having no effect on the SLB structure.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
A. R. Ortiz Moreno, R. Li, K. Wu, R. Schirhagl
Summary: Lipid peroxidation is a process where reactive oxygen species attack lipids within cell membranes, leading to toxic and carcinogenic products. Understanding this process at nanoscale resolution is important and challenging due to the short lifespan and reactivity of the radical intermediates involved. In this study, lipid peroxidation of three artificial lipid bilayers on a diamond substrate was investigated using a diamond quantum sensing method called T-1-relaxometry, allowing for in situ measurements and imaging of radical intermediates.
Article
Multidisciplinary Sciences
Anastassia A. Vorobieva, Paul White, Binyong Liang, Jim E. Horne, Asim K. Bera, Cameron M. Chow, Stacey Gerben, Sinduja Marx, Alex Kang, Alyssa Q. Stiving, Sophie R. Harvey, Dagan C. Marx, G. Nasir Khan, Karen G. Fleming, Vicki H. Wysocki, David J. Brockwell, Lukas K. Tamm, Sheena E. Radford, David Baker
Summary: Through computational design, researchers successfully developed novel TMBs with no homology to known TMBs, which can reversibly insert and fold into synthetic lipid membranes, and exhibit experimental structures highly similar to computational models. This advancement is expected to facilitate the custom design of pores for various applications.
Article
Polymer Science
Che-Lun Chin, Lu-Jan Huang, Zheng-Xian Lu, Wei-Chun Weng, Ling Chao
Summary: This study demonstrates that the water absorption ability of dried PAAm hydrogel can facilitate the formation of hydrogel-SLBs. The high quality of the hydrogel surface is crucial for SLB formation, and minimizing oxygen exposure during drying can prevent the formation of an oxidized crust.
Article
Chemistry, Physical
Niki Baccile, Anyssa Derj, Cedric Boissiere, Vincent Humblot, Ariane Deniset-Besseau
Summary: The development of supported glycosylated lipid layers using microbial biosurfactants provides a versatile and robust method for preparing defect-free and homogeneous lipid monolayers. The method offers precise control of thickness below 10 nm and is compatible with aqueous solutions. Characterization techniques show that the glycosylated SLM are uniformly thick at 2.8 +/- 1.0 nm and defect-free at nanometer to centimeter scales.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Hui Yin, Arielle C. Mensch, Christian A. Lochbaum, Isabel U. Foreman-Ortiz, Emily R. Caudill, Robert J. Hamers, Joel A. Pedersen
Summary: Supported lipid bilayers are important model systems for studying the interactions of proteins, peptides, and nanoparticles with biological membranes. The properties of the solid substrate, such as topography and coating, can affect the formation and properties of supported phospholipid bilayers. The interactions of nanoparticles with supported lipid bilayers depend on the substrate composition.
Article
Physics, Multidisciplinary
Shi Yu, Jianqiao Zhao, Ruizhi Chu, Xiao Li, Guoguang Wu, Xianliang Meng
Summary: This study presents mesoscale models for the anomalous diffusion of a polymer chain on a heterogeneous surface. The simulation results show that bead-spring chains exhibit sub-diffusion on charged lipid bilayers, while a simulated 17 base pairs double stranded DNA exhibits normal diffusion. The energy landscape experienced by short DNA chains is less heterogeneous compared to long DNA chains, resulting in different diffusion behaviors.
Article
Chemistry, Multidisciplinary
Claudia Lubrano, Ugo Bruno, Chiara Ausilio, Francesca Santoro
Summary: This study investigates the short-term depression of a biomembrane-based organic electrochemical transistor (OECT) through supported lipid bilayer mediation. The ionic barrier behavior of the lipid bilayer is utilized to enhance the neuromorphic operation of the OECT. These biomimetic neuromorphic devices pave the way for in vitro platforms resembling synapses to study and characterize synaptic plasticity loss in neurodegenerative diseases.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Daisuke Fujii, Kento Takase, Ami Takagi, Kei Kamino, Yoshiaki Hirano
Summary: The study focuses on the design and role of RGD-containing peptides in cellular activities, exploring their application in tissue engineering through analysis of peptide structures and mechanical properties, and demonstrating that peptide-coated cell culture substrates have a significant promoting effect on cell adhesion and spreading.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Svetlana S. Efimova, Anna I. Malykhina, Olga S. Ostroumova
Summary: Amphotericin B is an effective antifungal drug with low risk of resistance development, but its high toxicity limits its clinical use. This study explores the potential of plant polyphenols and alkaloids to enhance the antifungal activity of Amphotericin B by increasing pore formation.
Article
Biophysics
Autumn A. Anthony, Osman Sahin, Murat Kaya Yapici, Daniel Rogers, Aurelia R. Honerkamp-Smith
Summary: This study systematically measured the coefficient of interleaflet friction in supported lipid membranes using a microfluidic technique. The results showed that this technique provides reproducible measurements of the friction coefficient and is sensitive enough to detect differences in friction between different lipid membranes. Adding cholesterol significantly increased interleaflet friction. Additionally, fluid shear stress was found to reversibly induce the gel phase in supported lipid bilayers close to the gel-transition temperature.
BIOPHYSICAL JOURNAL
(2022)
Article
Infectious Diseases
Anastasiia A. Zakharova, Svetlana S. Efimova, Olga S. Ostroumova
Summary: This study investigated the ability of polymyxin B to form ion pores in model membranes, revealing that the antibiotic predominantly interacts with negatively charged lipids. The pore-forming ability of polymyxin B depends on the shape of membrane lipids and could be utilized to develop innovative lipopeptide-based formulations.
Article
Chemistry, Multidisciplinary
Chandradeep Basu, Himal Kanti Ganguly, Gautam Basu
Summary: The study shows that replacing a single residue in a beta-hairpin by Gly-Pro is well accommodated in the isolated beta-hairpin without causing much structural distortion, while Pro-Gly is not well accommodated in the same context.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Siddhartha Banerjee, Divya Baghel, Md Hasan Ul Iqbal, Ayanjeet Ghosh
Summary: Spontaneous aggregation of amyloid beta (Afi) proteins is a key pathological feature of Alzheimer's disease, but the structure of early-stage aggregates is not well understood. This study used atomic force microscopy-infrared nanospectroscopy to investigate the aggregation process of Afi 16-22 and found a structural transition from oligomers with parallel β-sheets to antiparallel fibrils.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Review
Chemistry, Physical
Ausra Valiunien, Gintaras Valincius
Summary: The current development status of impedimetric biosensors using tethered bilayer membranes (tBLMs) as sensing elements was reviewed. Understanding the nature of electrochemical impedance spectroscopy (EIS) response defined by the physical properties of tBLMs is crucial for designing and operating such sensors. Traditional parameters, such as membrane conductance derived from electric equivalent circuits, may not accurately measure the activities of pore-forming agents due to the unique molecular structure and physical properties of the submembrane reservoir and the dependence of measured EIS signals on the lateral 2D distribution of pores (defects) in tBLMs. Controlling the micro-heterogeneity of tBLMs and experimentally measuring the specific resistance of the submembrane reservoir offer a potential way to design robust tBLM biosensors with reproducible signals.
CURRENT OPINION IN ELECTROCHEMISTRY
(2023)
Review
Food Science & Technology
Panpan Wang, Mengzhen Ding, Ting Zhang, Tingting Wu, Ruirui Qiao, Fengping Zhang, Xichang Wang, Jian Zhong
Summary: This article provides an overview of the electrospraying technique and its recent application advances in biological macromolecule encapsulation of food bioactive substances. It covers the history, principles, setup, and products of electrospraying, as well as the application of electrosprayed particles with different structures for encapsulating nutrients and probiotics. The review summarizes the current state of electrospraying technique for biological macromolecule encapsulation and provides insights for future development.
FOOD REVIEWS INTERNATIONAL
(2022)
Article
Chemistry, Applied
Mengyang Yang, Lili Yang, Jiamin Xu, Yinghua Nie, Wenjuan Wu, Ting Zhang, Xichang Wang, Jian Zhong
Summary: This study comprehensively investigated the effects of extraction methods on the properties and emulsification ability of silver carp fin gelatins, highlighting the importance of molecular characteristics in determining their functionality. The findings contribute to a better understanding of the utilization potential of aquatic by-products and gelatins in high value-added applications.
Article
Food Science & Technology
Tingting Wu, Hao Guo, Ting Zhang, Rui Sun, Ningping Tao, Xichang Wang, Jian Zhong
Summary: The study established a manual comparative analysis method based on liquid chromatography-mass spectrometry-LipidSearch to analyze the effect of thermal processing methods on long-chain free fatty acid species in tilapia muscles. It was found that about 66 fatty acid species were present in raw and thermally processed tilapia muscles, with only five fatty acid species showing higher sensitivity in positive ionisation mode of mass spectrometry.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yifan Luo, Yidan Wang, Yue Ma, Puxiu Wang, Jian Zhong, Yang Chu
Summary: ARC is a phenomenon of increased renal function with sub-therapeutic drug concentrations and antibacterial exposure as main reasons for treatment failure in affected patients. Despite decades of research, there are still disputes and unresolved issues in this area. Future research should focus on clinical identification, metabolism, animal models, and treatment directions related to ARC.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xiangyan Wang, Lei Chen, Jianxian Ge, Mohammad Javad Afshari, Lei Yang, Qingqing Miao, Ruixue Duan, Jiabin Cui, Chunyi Liu, Jianfeng Zeng, Jian Zhong, Mingyuan Gao
Summary: The study demonstrated the development of high-performance MRI nanoprobes for glioblastoma diagnosis by combining Angiopep-2 with ultra-small iron oxide. The nanoprobes showed favorable imaging properties, low toxicity, and high specificity to glioblastoma cells, suggesting promising potential for clinical application.
Article
Nutrition & Dietetics
Liu Lin, Zhenhai Cao, Xuebing Zhang, Ming Kang, Xichang Wang, Jian Zhong, ChangHua Xu, Long Zhang, Ningping Tao, Shanggui Deng
Summary: This study investigated the effects of condiment (salt) and processing technic (homogenization) on the digestion and interfacial properties of micro/nano-sized colloidal particles (MNCPs) in bigeye tuna head soup (BTHS). The study found that both salt and homogenization can alter the size and structure of MNCPs, affecting their digestion in the gastrointestinal tract.
FRONTIERS IN NUTRITION
(2022)
Editorial Material
Nutrition & Dietetics
Jian Zhong, Enrique Barrajon-Catalan, Jose Manuel Lorenzo, Jun Lu, Brijesh K. Tiwari
FRONTIERS IN NUTRITION
(2021)
Article
Chemistry, Applied
Lili Yang, Mengyang Yang, Jiamin Xu, Yinghua Nie, Wenjuan Wu, Ting Zhang, Xichang Wang, Jian Zhong
Summary: This study compared the properties of different fish skin gelatins, and found that their gel strength is related to molecular weight and subunit content. Emulsion stability is closely related to protein chemical composition and secondary structure, providing important references for the comprehensive utilization of aquatic by-products in the gelatin industry.
Article
Chemistry, Applied
Yinghua Nie, Jiahui Chen, Jiamin Xu, Yangyi Zhang, Mengyang Yang, Lili Yang, Xichang Wang, Jian Zhong
Summary: The study showed that vacuum freeze-drying process affects the molecular structure and emulsion stability of gelatin extracted from tilapia skin, with longer drying times leading to changes in specific secondary structures and an enhancement in emulsion stabilization.
Article
Chemistry, Applied
Ting Zhang, Jiamin Xu, Shudan Huang, Ningping Tao, Xichang Wang, Jian Zhong
Summary: The study demonstrated that modifying gelatins with various anhydrides can affect their surface properties and emulsion stability. Acylated CFGs showed better stability and transition time compared to acylated BBGs. These findings are beneficial for the development and application of protein-based emulsifiers.
Article
Food Science & Technology
Jiamin Xu, Lili Yang, Yinghua Nie, Mengyang Yang, Wenjuan Wu, Zhengquan Wang, Xichang Wang, Jian Zhong
Summary: This study investigates the effects of transglutaminase (TG) modification on the structural, physicochemical, functional, and emulsion stabilization properties of different gelatins from various sources. The results demonstrate that TG modification can alter the behavior and properties of gelatins. TG-modified aquatic gelatin shows potential as a mammalian gelatin substitute.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Applied
Lina Tao, Jiamin Xu, Jiahui Chen, Lijie Liu, Ting Zhang, Ningping Tao, Xichang Wang, Jian Zhong
Summary: The study successfully prepared multicore millimeter-sized calcium alginate capsules using internal gelation technique, showing the potential for releasing fish oil.
FOOD HYDROCOLLOIDS
(2022)
Article
Food Science & Technology
Wenjuan Wu, Jiamin Xu, Lili Yang, Mengyang Yang, Ting Zhang, Xichang Wang, Jian Zhong
Summary: Enzymatic hydrolysis modification was combined with silver carp spine bone gelatin extraction to obtain pepsin enzyme hydrolyzed gelatins (PEHGs) for emulsion development. PEHGs showed higher emulsion stabilization ability and self-assembled into pH-stable nanoparticles. The nanoparticle sizes increased and the emulsion stability improved with the decrease of pepsin/vertebrae ratios in the preparation process.
Article
Biophysics
Jiamin Xu, Shudan Huang, Yangyi Zhang, Yulu Zheng, Wenzheng Shi, Xichang Wang, Jian Zhong
Summary: This study extracted aquatic gelatin from silver carp scales and studied the effects of different types of antioxidants on the stabilization, lipid oxidation, and in vitro digestion of the gelatin-stabilized fish oil emulsions. The results showed that the water-soluble antioxidant VC slowed the liquid-gel transition, while the lipid-soluble antioxidant VE increased the creaming stability of the emulsion.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Applied
Yangyi Zhang, Jiamin Xu, Ting Zhang, Lina Tao, Yinghua Nie, Xichang Wang, Jian Zhong
Summary: This study investigated the effects of monosaccharide glycosylation on the stabilization of fish oil-loaded emulsions using bovine bone gelatin. The results showed that the glycosylation of gelatin affected its structure, droplet stability, creaming stability, and liquid-gel transition time, depending on the carbon numbers and structures of the monosaccharides and the pH of the solution.
