Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
Volume 188, Issue -, Pages 116-125Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2018.08.004
Keywords
Biomedical; Cytotoxicity; Green synthesis; HepG(2) cells; Photo-mediated; Physalis peruviana; Silver nanoparticles
Categories
Funding
- Dongguk University, Republic of Korea
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) - Ministry of Agriculture, Food and Rural Affairs (MAFRA) [710003-07-7-SB120, 116075-3]
- Korea Environmental Industry & Technology Institute [A117-00197-0703-0]
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Silver nanoparticles (AgNPs) have been synthesized by various ways but the green technology methods using food waste materials has been accepted now a days for their cost effectiveness, environmental friendly and effective biomedical application. In the present study an attempt has been made to synthesize AgNPs by using the outer accrescent fruiting calyx of Physalis peruviana fruits, a food waste material under different light source condition, and to investigate their cytotoxic activity against the HepG(2) cells as well as their antibacterial and radical scavenging potential. The surface morphology and elemental composition of the biosynthesized AgNPs were evaluated by scanning electron microscopy, energy-dispersive X-ray analysis, and X-ray powder diffraction analysis. Fourier transform infrared spectroscopy of the sample extract and AgNPs was performed to determine the involvement of functional groups in the synthesis, capping, and stabilization process. The AgNPs showed promising cytotoxic activity against the HepG2 cells in a dose-dependent manner. The biosynthesized AgNPs also exhibited moderate antibacterial activity (8.14-10.22 mm inhibition zones) against two Gram-negative pathogenic bacteria with promising radical scavenging potential. Overall, the results highlight the effectiveness of the AgNPs for use in antibacterial wound dressing materials and other biomedical applications for the treatment of critical diseases such as cancer.
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