Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Volume 241, Issue -, Pages 52-57Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotochem.2012.05.014
Keywords
Photoremovable protecting group; Coumarin; Phototriggers; Caged peptides
Categories
Funding
- DFG [CA880/3-1]
Ask authors/readers for more resources
The synthesis, photochemical properties and chemical stability of 7-(N,N-diethylamino-coumarin-4-yl)-1-ethyl (DEACE) photoremovable protecting group for carboxylic acids are presented. We demonstrate that the ethyl substituent of DEACE improves the hydrolytic stability of the protected ester in basic conditions used in solid phase peptide synthesis (SPPS) and retains the good photochemical properties of the coumarin-4-yl methyl derivatives. DEACE allows the preparation of peptides with protected carboxylic side groups with high yield via SPPS. (C) 2012 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available