Hepatosteatosis and hepatic insulin resistance are blunted by argirein, an anti-inflammatory agent, through normalizing endoplasmic reticulum stress and apoptosis in diabetic liver

Implication of inflammatory signaling pathways in obesity-induced insulin resistance

(2013) Jean-François Tanti et al.   Frontiers in Endocrinology

Cytokines in alcoholic liver disease

(2012) Leon An et al.   ARCHIVES OF TOXICOLOGY

Effect of intracellular lipid accumulation in a new model of non-alcoholic fatty liver disease

(2012) Norberto C Chavez-Tapia et al.   BMC GASTROENTEROLOGY

Insulin resistance predicts progression of de novo atherosclerotic plaques in patients with coronary heart disease: a one-year follow-up study

(2012) Xuanqi An et al.   Cardiovascular Diabetology

Insulin Resistance in the Defense against Obesity

(2012) Alan R. Saltiel   Cell Metabolism

PPAR agonists for the treatment of cardiovascular disease in patients with diabetes

(2012) J. P. H. Wilding   DIABETES OBESITY & METABOLISM

Pharmacokinetic behavior of argirein, derived from rhein, is characterized as slow release and prolonged T1/2 of rhein in rats

(2012) Xiao-Dong Cong et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

Nonalcoholic steatohepatitis versus steatosis: Adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism

(2012) Giovanni Musso et al.   HEPATOLOGY

Activation of AQP4, p66Shc and endoplasmic reticulum stress is involved in inflammation by carrageenan and is suppressed by argirein, a derivative of rhein

(2012) Xiao-Dong Cong et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Insulin Resistance and Heart Failure

(2012) Annayya R. Aroor et al.   Heart Failure Clinics

Oxidative stress induces unfolding protein response and inflammation in nasal polyposis

(2011) L. Jeanson et al.   ALLERGY

Insulin receptor substrate-1 and -2 mediate resistance to glucose-induced caspase-3 activation in human neuroblastoma cells

(2011) Oliver Stöhr et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Urban planning of the endoplasmic reticulum (ER): How diverse mechanisms segregate the many functions of the ER

(2011) Emily M. Lynes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Valsartan protects against ER stress-induced myocardial apoptosis via CHOP/Puma signaling pathway in streptozotocin-induced diabetic rats

(2011) Tingting Wu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

ER Stress, P66shc, and P-Akt/Akt Mediate Adjuvant-Induced Inflammation, Which Is Blunted by Argirein, a Supermolecule and Rhein in Rats

(2011) Xiao-Dong Cong et al.   INFLAMMATION

Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue

(2011) C. Hu et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

SNARE Proteins Underpin Insulin-Regulated GLUT4 Traffic

(2011) Nia J. Bryant et al.   TRAFFIC

Protective effects of Pycnogenol® on hyperglycemia-induced oxidative damage in the liver of type 2 diabetic rats

(2010) Kehkashan Parveen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Leptin induces hypertrophy through activating the peroxisome proliferator-activated receptor α pathway in cultured neonatal rat cardiomyocytes

(2010) Ning Hou et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Oxidative stress, insulin signaling, and diabetes

(2010) Justin L. Rains et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C

(2010) Carmelo García-Monzón et al.   JOURNAL OF HEPATOLOGY

Regulation of the human CHOP gene promoter by the stress response transcription factor ATF5 via the AARE1 site in human hepatoma HepG2 cells

(2010) Takashi Yamazaki et al.   LIFE SCIENCES

Bisphenol A induces endoplasmic reticulum stress-associated apoptosis in mouse non-parenchymal hepatocytes

(2010) Junpei Asahi et al.   LIFE SCIENCES

Regulation of synthesis and oxidation of fatty acids by adiponectin receptors (AdipoR1/R2) and insulin receptor substrate isoforms (IRS-1/-2) of the liver in a nonalcoholic steatohepatitis animal model

(2010) Tokio Matsunami et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Testis dysfunction by isoproterenol is mediated by upregulating endothelin receptor A, leptin and protein kinase Cɛ and is attenuated by an endothelin receptor antagonist CPU0213

(2010) Yu-Si Cheng et al.   REPRODUCTIVE TOXICOLOGY

Fatty liver and lipotoxicity

(2009) Michael Trauner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hepatic insulin resistance, metabolic syndrome and cardiovascular disease

(2009) Reza Meshkani et al.   CLINICAL BIOCHEMISTRY

Rhein Improves Renal Lesion and Ameliorates Dyslipidemia in db/db Mice with Diabetic Nephropathy

(2009) Qing Gao et al.   PLANTA MEDICA

Effect of early insulin therapy on nuclear factor κB and cytokine gene expressions in the liver and skeletal muscle of high-fat diet, streptozotocin-treated diabetic rats

(2008) Y. Bi et al.   ACTA DIABETOLOGICA

Normalizing NADPH Oxidase Contributes to Attenuating Diabetic Nephropathy by the Dual Endothelin Receptor Antagonist CPU0213 in Rats

(2008) Ming Xu et al.   AMERICAN JOURNAL OF NEPHROLOGY

Glimepiride as insulin sensitizer: increased liver and muscle responses to insulin

(2008) R. C. T. Mori et al.   DIABETES OBESITY & METABOLISM